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Novel Targeted Agent Shows Promise in Acute Myeloid Leukemia
An oral inhibitor of isocitrate dehydrogenase 2 (IDH2), AG-221, has shown activity and potentially durable remissions in patients with acute myeloid leukemia.
Acute Lymphoblastic Leukemia Responds to Immunotherapy
A single cycle of blinatumomab resulted in complete minimal residual disease response in 78% of patients with acute lymphoblastic leukemia.
AETHERA: Brentuximab Vedotin Delays HL Progression Post-ASCT
Early consolidation therapy with brentuximab vedotin after autologous stem cell transplant improved progression-free survival of patients with Hodgkin lymphoma.
Anti–PD-1 Agent Pembrolizumab Promising in Classic Hodgkin Lymphoma
The anti-PD-1 drug pembrolizumab demonstrated promising anti-tumor activity in patients with heavily pretreated classic Hodgkin lymphoma.
New Developments in Multiple Myeloma
In this podcast from the 2014 American Society of Hematology Annual Meeting, we discuss some of the new developments in multiple myeloma.
Nivolumab Demonstrates Activity in Hematologic Cancers
The anti–PD-1 (programmed death 1) antibody nivolumab has shown activity in patients with hematologic cancers who have failed three or more prior therapies.
Adding Carfilzomib to Myeloma Treatment Results in ‘Unprecedented’ Boost in PFS
Adding carfilzomib to lenalidomide and dexamethasone resulted in a higher PFS and better overall quality of life for relapsed multiple myeloma patients.
COG Trial: T-ALL Not a Poor-Risk Disease in Pediatric Patients
T-lymphoblastic leukemia (T-ALL) should no longer be considered a poor-risk disease in the pediatric population, according to data presented at ASH.
Sorafenib Effective in Younger Patients with AML
Sorafenib proved to have a high level of efficacy in younger acute myeloid leukemia patients, improving both event- and relapse-free survival over placebo.
FDA Approves Blinatumomab for Acute Lymphoblastic Leukemia
The FDA has approved blinatumomab (Blincyto) for the treatment of patients with Philadelphia chromosome-negative precursor B-cell acute lymphoblastic leukemia.