CONFERENCE REPORT Cancer Network presents exclusive coverage from the American Society of Hematology (ASH) annual meeting. We'll bring you onsite reports as we cover the latest research, trials, scientific advances, and controversies that are changing the way hematologic malignancies are managed and treated.
REVIEW ARTICLE Michael S. Mathisen, Elias Jabbour, Hagop M. Kantarjian;ONCOLOGY Vol. 26 No. 9 In this review, we will discuss the management of ALL in the adult population, in the context of the recently published guidelines from the NCCN. We will focus in particular on the strides being made in salvage and targeted approaches.
REVIEW ARTICLE Loretta J. Nastoupil, et al;ONCOLOGY Vol. 26 No. 5 This article examines clinical and biological features of DLBCL patients with poor outcomes, and reviews recent studies addressing alternatives to standard front-line management strategies together with unresolved questions.
REVIEW ARTICLE Bradford S. Hoppe, et al;ONCOLOGY Vol. 26 No. 5 This review addresses the rationale and evidence for—and the challenges, cost implications, and future development of—proton therapy as an important part of the treatment strategy in Hodgkin lymphoma.
A 53-year-old woman presented with abominal pain. Physical examination and radiographic imaging shows the presence of an abdominal mass. Biopsy of the mass was performed. What is your diagnosis?
A 62-year-old man presented with symptoms of nasal congestion. Physical and radiographic imaging shows the presence of a nasal mass. Biopsy was performed. What is your diagnosis?
A hematologically stable CML patient developed a solitary, exquisitely painful ulceration, 7 cm × 5 cm, located on the mid-medial foreleg. There was never any evidence of venous insufficiency. The patient denied the possibility of a spider bite. What is the likely cause of this lesion?
As an avid gardener, the patient spent considerable time outdoors and had never before experienced a similar problem. However, during the prior two spring-summer seasons. Almost every witnessed mosquito bite resulted in either a swollen, pruritic nodule or a substantial blister. This patient most likely has what underlying disease?
A 58-year-old man developed acute myeloid leukemia. After responding to remission-induction high-dose chemotherapy, he received an allogeneic stem cell transplant that was complicated by a graft-versus-host reaction. While being treated for the latter with prednisone, tacrolimus (Prograf), and mycophenolate mofetil (CellCept), he developed both fungal pneumonia and osteomyelitis caused by Fusarium species.
DLBCL of any stage remains a systemic disease with early hematogenous spread. Thus, arguments advocating the role of IFRT do not truly address disease... More »
Researchers have characterized acute myeloid leukemia, providing new genetic driver leads to help classify the disease and even stratify AML patients... More »
In this review, we critically analyze clinical trials that were specifically designed for the very elderly, and we discuss the challenges encountered... More »
A genome-wide study, and analysis of genes in Reed-Sternberg cells, suggest molecular subtypes that should lead to better therapies and prognostic... More »
The likelihood that combined-modality therapy will provide a small progression-free survival advantage is real but not likely to be equated to an... More »
In this interview we discuss the current management and latest treatments and agents in development for multiple myeloma with Dr. Kenneth Anderson of the Dana-Farber Cancer Institute.
Primary Care Can't Thrive Without Nurse Practitioners Courtney H. Lyder, ND, May 17, 2013 With a projected shortfall of primary-care physicians, it's time for alternate solutions to patient care. Nurse practitioners are one logical remedy.
In this review, we critically analyze clinical trials that were specifically designed for the very elderly, and we discuss the challenges encountered by investigators who are conducting studies in this patient population. We conclude by proposing an algorithm to help clinicians determine the optimal therapeutic strategy for treatment of DLBCL in very elderly patients.
In Hodgkin lymphoma, as with many other malignancies, a combined-modality approach has proven successful. This tactic capitalizes on the relative advantages of both modalities, yet minimizes risk by avoiding intense exposure to either. This article will summarize the data supporting this approach in early-stage Hodgkin lymphoma.
This review will discuss the pathophysiology associated with the del(17p13.1) interphase cytogenetic abnormality, the current generally poor outcomes in affected patients, currently approved therapeutic agents, and new agents now undergoing investigation.
Is it reasonable to start all new CML patients on treatment with imatinib alone and continue the drug indefinitely in those who fare well, or should one start treatment with one of the newer agents or possibly with imatinib in combination with another anti-CML agent in order to secure the best possible outcome for an individual patient?
In this review, we will discuss the management of ALL in the adult population, in the context of the recently published guidelines from the NCCN. We will focus in particular on the strides being made in salvage and targeted approaches.
A 53-year-old woman presented with abominal pain. Physical examination and radiographic imaging shows the presence of an abdominal mass. Biopsy of the mass was performed. What is your diagnosis?
A 62-year-old man presented with symptoms of nasal congestion. Physical and radiographic imaging shows the presence of a nasal mass. Biopsy was performed. What is your diagnosis?
A hematologically stable CML patient developed a solitary, exquisitely painful ulceration, 7 cm × 5 cm, located on the mid-medial foreleg. There was never any evidence of venous insufficiency. The patient denied the possibility of a spider bite. What is the likely cause of this lesion?
As an avid gardener, the patient spent considerable time outdoors and had never before experienced a similar problem. However, during the prior two spring-summer seasons. Almost every witnessed mosquito bite resulted in either a swollen, pruritic nodule or a substantial blister. This patient most likely has what underlying disease?
A 58-year-old man developed acute myeloid leukemia. After responding to remission-induction high-dose chemotherapy, he received an allogeneic stem cell transplant that was complicated by a graft-versus-host reaction. While being treated for the latter with prednisone, tacrolimus (Prograf), and mycophenolate mofetil (CellCept), he developed both fungal pneumonia and osteomyelitis caused by Fusarium species.
Hematology Letters is a new blog for Cancer Network written by Mojtaba Akhtari, MD of the University of Nebraska Medical Center, Omaha, Nebraska.
In this interview we discuss the current management and latest treatments and agents in development for multiple myeloma with Dr. Kenneth Anderson of the Dana-Farber Cancer Institute.
