REVIEW ARTICLE Philippa J. Cheetham, Daniel P. Petrylak; ONCOLOGY Vol. 26 No. 4 This article will present current information about alpha-pharmaceuticals and review preclinical and clinical studies of the experimental radiopharmaceutical radium-223 chloride (Alpharadin). • Radium-223: Down to the Bone, and Less Is More • An Alpha Edge? REVIEW ARTICLE Yesim Gökmen-Polar, Sunil Badve; ONCOLOGY Vol. 26 No. 4 In this review, we will present the current data on commercially available molecular profiling assays in breast cancer and discuss the challenges surrounding their incorporation into routine clinical practice as prognostic and predictive tools. • Beyond Prime Time and Into Syndication • A Perspective on Genomic Tests for Breast Cancer: The Need for Progress REVIEW ARTICLE C. Michele Burnison, Stephen Lim; ONCOLOGY Vol. 26 No. 4 In this article, we endeavor to clarify the role of radiation therapy and chemotherapy in the treatment of ATC; we note important contributions of the historical literature, and we review more contemporary strategies adopted by several renowned institutions. • Toward Improved Outcomes in Patients With Anaplastic Thyroid Cancer • Time to Change the Treatment Paradigms in Anaplastic Thyroid Carcinoma REVIEW ARTICLE Sarah A. McLaughlin; ONCOLOGY Vol. 26 No. 3 Given the abundance of breast cancer data, this review will focus on breast cancer–related lymphedema. However, the principles and controversies discussed are relevant regardless of the type of malignancy to which the lymphedema is attributed. • Lymphedema Prevention and Early Intervention: A Worthy Goal • Lymphedema: Still a Problem Without an Answer REVIEW ARTICLE David L. Bartlett, Edward Chu; ONCOLOGY Vol. 26 No. 3 Despite advances in targeted biologic agents, the impact of new regimens in mCRC therapy has been modest. This article reviews the main issues that must be considered from the surgical and medical oncology perspectives. • Metastatic Colorectal Cancer: A Curable Disease • Metastatic Colorectal Cancer: Potential for Cure? REVIEW ARTICLE Catherine Thieblemont et al; ONCOLOGY Vol. 26 No. 2 In this article, we review the current knowledge on the biological findings, clinical features, and therapeutic approaches for splenic marginal zone lymphoma. • Splenic Lymphomas: Is There Still a Role for Splenectomy? • Splenic Marginal Zone Lymphoma: Villous, Not Necessarily Villainous
Improving the Therapeutic Ratio in Hodgkin Lymphoma Through the Use of Proton Therapy
Bradford S. Hoppe, MD, MPH1,
Stella Flampouri, PhD1,
James Lynch, MD2,
William Slayton, MD3,
Robert Zaiden, MD4,
Zuofeng Li, DSc1,
Nancy P. Mendenhall, MD1
, May 15, 2012
This review addresses the rationale and evidence for—and the challenges, cost implications, and future development of—proton therapy as an important part of the treatment strategy in Hodgkin lymphoma.
• Protons: Moving Therapy for Hodgkin Lymphoma in a Positive Direction
• Proton Radiotherapy: The Good, the Bad, and the Uncertain
Breast Cancer Screening: The Evolving Evidence
Robert A. Smith, PhD1,
Stephen W. Duffy, MSc2,
László Tabár, MD, FACR (Hon)3
, May 15, 2012
In this paper, the historic and recent evidence supporting the value of breast cancer screening will be described, along with the underpinnings of the current debate over the relative and absolute benefit of regular mammography screening.
• Effectiveness of Breast Cancer Screening: What Are the Metrics
• Breast Cancer Recurrence Is Dictated by High-Risk Biology, Not Choice of Surgery
Genetic Testing in Gastrointestinal Cancers: A Case-Based Approach
Kasmintan Schrader, MD1,
Kenneth Offit, MD, MPH1,
Zsofia K. Stadler, MD1
, May 15, 2012
In this article, we use a case-based approach to focus on the hereditary aspects of the most common GI cancers, including pancreatic, gastric, and colon cancer.
• Genetic Testing in Cancer: Ethical Issues
• Genetic Testing: The Bigger Picture
The Information Age, Cyberspace, and Cancer
Edward P. Ambinder, MD1
, April 17, 2012
Oncologists and their patients are facing disruptive changes in healthcare, research, and communication. This dramatic increase in the quantity and quality has changed our lives forever. However, many of us remain frustrated with our inability to control this information overload.
Systemic Therapy in Renal Cell Carcinoma: Advancing Paradigms
Edwin M. Posadas, MD, FACP1,2, Robert A. Figlin, MD, FACP1,2
, March 13, 2012
This article will review the recent advances that form the current framework of therapy for RCC, as well as summarize key areas of progress and innovation in the evolving treatment paradigms for this disease.
•
Renal Cancer Therapeutics: Now What?
• Metastatic RCC: Moving Towards a Chronic Disease
How I Survived Chemotherapy
Craig R. Hildreth, MD
, May 18, 2012
I confess that I have never taken chemotherapy. Strictly speaking this disqualifies me from commenting any further, so I should sign off now. If, however, you don’t mind hearing from one who has administered chemotherapy by the thousands and can bear witness to its effects, then please read on.
IBM's Watson Decides to Try Its Hand at Oncology
Satish Misra, MD1
, April 13, 2012
Just over a year ago, Alex Trebek introduced the world to Watson. IBM insists that Watson is a decision-support tool, meant to assist and not supplant physicians. How might it work in oncology?
The Golden Era of Genomics and Management of Acute Myeloid Leukemia
Mojtaba Akhtari, MD1
, April 12, 2012
Cancer treatment is undergoing significant developments and entering the new golden era of genomics which has true potentials for the promise of personalized medicine. Large-scale sequencing is changing our understanding of malignant disorders particularly acute myeloid leukemia.
“I’m Not Going to Treat Your Cancer”
Craig R. Hildreth, MD
, March 30, 2012
Of all the sad pronouncements that oncologists deliver, this may be the one that stings the most. If you were expecting hope from your doctor, how would you react to these words? Would you sit with quiet disbelief, or storm out of the office?
The Hateful Patient
Craig R. Hildreth, MD
, February 17, 2012
All those who walk through your doorway become your responsibility, at least until you either cure them, satisfy them, or in the rare case of incorrigibles, banish them. Opening our office to all comers is part of every doctor's commitment to the sick, and the faster we accept this, the smoother our day will proceed. Sometimes, though, it ain’t easy.
Current Challenges in Metastatic Breast Cancer: Patient Management and Treatment Strategies Interactive Case Challenge Series This series of case presentations (five individual cases) will provide oncologists and other healthcare professionals with strategies for evaluating evidence-based data on the latest treatments in metastatic breast cancer (MBC) and the application of that data into the development of individualized approaches to care, including overcoming resistance, in order to optimize management and outcomes for patients. Go to Activity
CancerNetwork.com offers a variety of Continuing Medical Education (CME) programs based on ONCOLOGY review articles, supplements to ONCOLOGY, textbooks, roundtable discussions, e-learning programs, and webcasts. These interactive CME activities are offered to physicians and other healthcare professionals without charge by CME. CME LLC is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. See a list of more Oncology CME activities.
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CancerNetwork presents exclusive coverage from the Miami Breast Cancer Conference, bringing all the top stories to come out of this year's meeting.
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CancerNetwork presents exclusive coverage from the annual San Antonio Breast Cancer Symposium. This year's coverage includes a podcast with Kent Osborne plus reports of the top stories from this year's meeting.
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CancerNetwork presents exclusive coverage from the American Society of Hematology (ASH) annual meeting, including a podcast, and reports on the top stories from San Diego.
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This year's coverage of the annual meeting of the American Society of Clinical Oncology (ASCO) includes podcasts, videos, and write-ups of the most important information to come out of this year's event.
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