A 54-year-old woman, previously in excellent health, noted the insidious development of abundant, thin, and softly textured, nonpigmented hair on her ears and nose. A detailed review of systems was entirely negative, and both a complete blood count and automated routine biochemistry panel were normal. Gynecologic examination, including a pap smear, was normal one year prior to presentation. The patient was a lifelong nonsmoker and nondrinker. Family history was negative for cancer.

A 43-year-old woman presented with symptoms of abdominal pain and uterine bleeding. At physical examination, a palpable mass was present in the right lower abdominal quadrant.

A 58-year-old man presented with symptoms of abdominal pain of several weeks duration. At physical evaluation, jaundice and ascites were present. In addition, a palpable mass was identified in the right upper quadrant. Surgical resection was performed.

A 45-year-old woman presented with severe back pain. After radiological and physical examination, the patient was found to have nephrolithiasis with marked hypercalcemia. In addition, a palpable mass in the right side of the neck was encountered. Surgical resection of the mass was performed.

A 67-year-old Caucasian male presents in the month of April with a spontaneously painful and tender-to-the-touch erythema involving the face, dorsal and distal forearms, dorsal hands, and V-area of the neck/anterior chest. He has cancer and is being treated with one or more chemotherapeutic agents.

A 3-year-old child was brought to the physician’s office after the mother felt a mass in the abdominal area. Imaging revealed the presence of a mass that appeared to be in the right kidney. Surgical resection of the tumor was performed.

A 43-year-old woman presented with intermittent pain and muscle weakness in the right side of her neck. At physical examination, a large mass was found in the parotid region. Parotidectomy was performed.

A 30-year-old man presented with pain and testicular swelling of his right testicle. The patient has not experienced any trauma, and states that otherwise he feels in good health.

A 37-year-old man presented with a mass in his right ankle. Resection of the mass was performed. What is the most likely result of a molecular study, and based on the histological and molecular features of this tumor, what is you diagnosis?

As an avid gardener, the patient spent considerable time outdoors and had never before experienced a similar problem. However, during the prior two spring-summer seasons. Almost every witnessed mosquito bite resulted in either a swollen, pruritic nodule or a substantial blister. This patient most likely has what underlying disease?

An 18-year-old man presented with cough and dyspnea of several weeks duration. The patient does not have any previous significant medical history and had been well until the cough began. Radiographic imaging revealed the presence of a tumor in the main-stem bronchus. Surgical resection of the mass was performed.

A 67-year-old African American female presented with an approximately 18-month history of a solitary, asymptomatic lesion on the right leg. This patient most likely has what tumor on her leg?

A 68-year-old woman presented with a mass on the scalp which had been present for approximately 7 years. An incisional biopsy of the scalp mass and excisional biopsy of the lymph node both revealed basal cell carcinoma, micronodular histologic subtype.

A 28-year-old, slightly obese Caucasian woman presented with a long-standing history of intermittently painful “bumps” on both shoulders and her upper back. Review of systems disclosed regular but very heavy menstrual periods, often lasting for 7 to 9 days, and chronic constipation.

A 46-year-old woman presented for medical evaluation due to a 2-month history of increasing difficulty in ambulation, especially getting up out of a chair or climbing stairs. She had also noticed swelling and discoloration of both upper eyelids (as depicted).