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Neoplasm Lacking the Usual Genetic Markers Associated With Colorectal Neoplasms

By Robert D. Cardiff, MD, PhD | April 6, 2011

Professor of Pathology, Emeritus, Center for Comparative Medicine, University of California, Davis

The Correct Answer is D: Flat Adenoma
These lesions were initially identified over 20 years ago in Japan. However, they have now been recognized in the United States and Europe. They appear to have a lower frequency of Ras, p53 and other mutations which are commonly associated with other colorectal cancers. This suggests that flat adenomas represent a separate malignant pathway. Their biological significance and frequency is still controversial.

Reference
Lau PC, Sung JJ. Flat adenoma in colon: two decades of debate. J Dig Dis. 2010 Aug;11(4):201-207.

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TOPIC INDEX

Cancer Types
Breast Breast (HER2+) Breast (Triple-Negative) CML Colorectal Gastrointestinal GIST Genitourinary Gynecologic Head & Neck	Hematology Kidney (Renal Cell) Leukemia Lung Lymphoma Melanoma Multiple Myeloma Ovarian Prostate Sarcoma
Supportive Care	More Topics
Bone Metastases End-of-Life Care Palliative Care	Ethics in Oncology Practice Management Practice & Policy

All Topics