Pages: 1 2 3

TEST YOUR IMAGE IQ

Peripheral Blood Showing Markedly Increased WBC

By Robert D. Cardiff, MD, PhD | April 21, 2011

Professor of Pathology, Emeritus, Center for Comparative Medicine, University of California, Davis

How your colleagues voted:

The Correct Answer for Question 1 is D: CML

The Correct Answer for Question 2 is A: t(9;22) (q34;q11)

A majority of CML patients have the BCR/ABL gene. This gene is the result of a 9;22 translocation (aka Philadelphia chromosome), part of the BCR region from chromosome 22 fuses with the ABL gene on chromosome 9. This abnormal gene generates tyrosine kinase that promotes increased cell growth.

Provided by the Center for Genomic Pathology

Reference:
Branford S, Hughes TP Mutational analysis in chronic myeloid leukemia: when and what to do? Curr Opin Hematol. 2011 Mar;18(2):111-6. PMID: 21245758

Pages: 1 2 3

More Image IQs

A 47-Year-Old Patient With Chronic Abdominal Pain

NSCLC Patient Develops Erythema After Vancomycin Infusion

Leukocoria (White Pupil) in 3-Year-Old Patient

Subcutaneous Nodule Excised From 38-Year-Old Patient

Young Man With a History of Headaches and Blurred Vision

Tumor Found in 42-Year-Old Patient During Hysterectomy

Testicular Mass Discovered in 28-Year-Old Patient

Abdominal Mass Found in 53-Year-Old Patient

Pleural Nodules Discovered in 34-Year-Old Woman

A 45-Year-Old Woman With an Incidental Finding on MRI

Thoracic Mass Discovered in 56-Year-Old Patient

Mildly Pruritic Skin Eruption in 44-Year-Old Taiwanese Immigrant

Multiple Liver Nodules Discovered in 43-Year-Old Patient

Soft-Tissue Mass in Left Forearm of 38-Year-Old Man

A Patient With Intermittent Headaches and Visual Changes

Posterior Mediastinal Mass Discovered in 48-Year-Old Man

A 74-Year-Old Caucasian Man Presents With Asymptomatic Navel “Lump”

A 63-Year-Old Man Presents With Symptoms of Blood in the Urine

Chest X-Ray of 27-Year-Old Woman Reveals ‘Sandstorm’ Pattern

Severe Abdominal Pain in 67-Year-Old Patient

A 34-Year-Old Man Presents With an Expanding Lesion on the Right Arm

A 58-Year-Old Woman Develops a Pruritic, Erythematous Plaque Involving the Areola

Asymptomatic 57-Year-Old Man Undergoes Prostate Biopsy

A 72-Year-Old Man Presents With Symptoms of Abdominal Pain and Bloody Stools

Chest Wall Tumor Discovered in 12-Year-Old Girl

Abdominal Mass Found in 48-Year-Old Patient

46-Year-Old CML Patient Develops Painful Ulceration

A 53-Year-Old Man Presents With Painful Neck Swelling

A 35-Year-Old Man With Axillary Lymphadenopathy

Intracranial Mass Discovered in 52-Year-Old Woman

NSCLC Patient Develops Fever and Rash Following Treatment for Brain Metastases

Bronchial Mass Discovered in 47-Year-Old Woman

Enlarging Scalp Nodules on 56-Year-Old Patient

A 43-Year-Old Man Is Found to Have an Anterior Mediastinal Mass

Large, Right Kidney Mass Discovered in 48-Year-Old Woman

A 57-Year-Old Man Presents With Symptoms of Dyspnea and Chest Pain

A 49-Year-Old Woman Notes the Onset of a Painful Reddish-Blue Discoloration Under One Fingernail

A 34-Year-Old Man Presents With Pain in the Right Thigh

A 48-Year-Old Woman With Abdominal Pain; Mass in the Duodenum Is Discovered

Biopsy of a Destructive Femur Mass From an 18-Year-Old Man

Mass Discovered in the Pancreas of a 28-Year-Old Woman

A 54-Year-Old Woman Notes the Abundant Development of Nonpigmented Hair on Her Ears and Nose

A 43-Year-Old Woman Presents With Symptoms of Abdominal Pain and Uterine Bleeding

A 58-Year-Old Man Presents With Abdominal Pain and Jaundice

A 45-Year-Old Woman Presents With Severe Back Pain; Examination Reveals Nephrolithiasis

67-Year-Old Male Cancer Patient Presents With a Painful Erythema Involving the Face, Arms, and Chest

Mass Found in the Abdominal Area of a 3-Year-Old Child

A 43-Year-Old Woman Presents With a Large Neck Mass

A 30-Year-Old Man Presents With Swelling of the Right Testicle

A 37-Year-Old Man Presents With a Right Ankle Mass

A 61-Year-Old Caucasian Woman Presents With History of “Bizarre Insect Bites”

An 18-Year-Old Man Presents With Cough and Dyspnea, Radiographic Imaging Reveals a Tumor

A 67-Year-Old African American Woman Presents With a Lesion on the Right Leg

A 68-Year-Old Woman Presents With Scalp Mass, Biopsy Reveals Basal Cell Carcinoma

A 28-Year-Old Woman Presents With a Long-Standing History of Intermittently Painful “Bumps” on Both Her Shoulders and Upper Back

46-Year-Old Woman Presents With Difficulty in Ambulation, and Swelling and Discoloration of Both Eyelids

HIV-Positive Male Presents With Multiple Symptoms and Has a History of Colonic Polyps

60-Year-Old Woman Treated for RCC Develops a Nonpruritic, Slightly Tender Cutaneous Eruption

A 48-year-old African American Female Presents With Severe Uterine Bleeding

A 29-Year-Old Man Presents With Stage IV, Poorly Differentiated Malignant Melanoma

Adult Male With Peutz-Jeghers Syndrome Complains of Upper Abdominal Pain

A 56-Year-Old Man With RCC Develops Minimally Pruritic, Bright Red Erythema and Fine Scale on the Scrotum

Painful Palpable Area in Right Breast Accompanied by a Straw-Colored Nipple Discharge in 22-Year-Old Woman

Patient With AML Develops Fungal Pneumonia and Osteomyelitis Following Treatment

17-Year-Old Patient With Li-Fraumeni Syndrome Presents With Large Mass in the Right Shoulder

HCC Patient on Sorafenib Develops Two Nodules

7-Year-Old Girl With Hereditary Multiple Exostosis Presents With a Painful Mass on Her Right Femur

2-Year-Old Girl with ALL Develops Two Hemorrhagic Bullae in the Groin

58-Year-Old Male Presents With Stomach Mass

Cutaneous Eruption in Metastatic HCC Patient Treated with Sorafenib

Medullary Thyroid Cancer in a 28-Year-Old Male

Patient With Supraglottic Squamous Cell Carcinoma Develops Painful Swelling on Both Great Toes

Mammary Gland Biopsy of 38-Year-Old Patient

A 78-Year-Old Woman With Nonpruritic Periorbital Purpura Around Her Eyelids

63-year-old Male Hospitalized Following a Massive Hemorrhage

A 58-Year-Old Woman on Gemcitabine Developed Swelling and Erythema of Both Legs

Neonate With a Soft, Yellowish-Colored Plaque on the Temple

38-Year-Old Primiparous Woman With Nipple Discharge

14-Month-Old with Multiple Dome-Shaped Yellow Papulonodules

71-Year-Old Male Presents for Evaluation of Painless Bump on His Chin

Core Biopsy of Prostate From an Elderly Male

Persistent, Intensely Painful Ulceration of the Contralateral Breast

Photosensitive Facial Rash Depicted Along with Polyarticular Arthralgias

Mass Found in Left Kidney of Patient With von Hipple-Lindau Syndrome

Painful, Hot Gluctuant Lump on Chin of Breast Cancer Patient

Peripheral Blood Showing Markedly Increased WBC

Rapidly Growing Pedal Lesions Following Chemotherapy

Neoplasm Lacking the Usual Genetic Markers Associated With Colorectal Neoplasms

Progressively Enlarging Mass on the Lower Back

Pruritic Discoloration Following ABVD Therapy

TOPIC INDEX

Cancer Types
Breast Breast (HER2+) Breast (Triple-Negative) CML Colorectal Gastrointestinal GIST Genitourinary Gynecologic Head & Neck	Hematology Kidney (Renal Cell) Leukemia Lung Lymphoma Melanoma Multiple Myeloma Ovarian Prostate Sarcoma
Supportive Care	More Topics
Bone Metastases End-of-Life Care Palliative Care	Ethics in Oncology Practice Management Practice & Policy

All Topics