Answer 1: A (Non–small-cell lung cancer)
Answer 2: B (Desmosomes)
Comment: Lung cancers are now classified as: non–small-cell lung cancer (which includes squamous cell carcinoma and adenocarcinoma) or small-cell carcinoma with a miscellaneous category (including pleomorphic, carcinoid, salivary gland, and unclassified). Within these morphological types, numerous genetic alterations have been found. The literature has numerous studies implicating genetic and epigenetic changes that lead to tumorigenesis as well as implications for prognosis and treatment.
This Image IQ has been provided by the Center for Genomic Pathology
Sy SM, Wong N, Lee TW, et al. Distinct patterns of genetic alterations in adenocarcinoma and squamous cell carcinoma of the lung. Eur J Cancer. 2004 May;40:1082–1094. PubMed PMID:15093586.