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Mass Found in Lung of 61-Year-Old Male

By Robert D. Cardiff, MD, PhD | July 7, 2011

Professor of Pathology, Emeritus, Center for Comparative Medicine, University of California, Davis

The correct answer is C: Small-cell carcinoma

61-year-old male with 3 month history of cough. Mass found in lung and excised.

Comment: This was originally diagnosed as a small-cell carcinoma of the lung. However, the cells exceed the size criteria of scanty cytoplasm and a diameter no more than three resting lymphocytic nuclei. The cytoplasm is also abundant. A panel of experts classified this as a small-cell carcinoma of the lung, intermediate grade. The case illustrates the ambiguity in some of our diagnostic criteria.

This Image IQ has been provided by the Center for Genomic Pathology

References:
Travis WD. Lung tumours with neuroendocrine differentiation. Eur J Cancer. 2009 Sep;45 Suppl 1:251-66. Review. PubMed PMID: 19775623.

den Bakker MA, Willemsen S, Grünberg K, Noorduijn LA, van Oosterhout MF, van Suylen RJ, Timens W, Vrugt B, Wiersma-van Tilburg A, Thunnissen FB. Small cell carcinoma of the lung and large cell neuroendocrine carcinoma interobserver variability. Histopathology. 2010 Feb;56(3):356-63. PubMed PMID: 20459535.

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Cancer Types
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Supportive Care	More Topics
Bone Metastases End-of-Life Care Palliative Care	Ethics in Oncology Practice Management Practice & Policy

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