The correct answer is C: Leiomyoma
Comment: Leiomyomas (fibroids) are very common benign uterine tumors. It is estimated that 25% of women in their reproductive years will develop fibroids. They rarely progress into a malignancy. Until recently, it was thought that both progesterone(Drug information on progesterone) and estrogen were the prime influencing factors in fibroid formation and there is considerable evidence that supports their involvement. Recent studies, however, indicate that other factors may also play key roles. These include an inherited component and also growth factors such as: transforming growth factor-beta, fibroblast growth factor, epidermal growth factor and platelet-derived growth factor.
The exact inherited component is unknown at this time but the fact that fibroids run in families is an indicator that one or more will be found. Further, a recent study demonstrated that 70% of fibroids exhibited mutations in MED12. These studies, and others, provide the current working hypothesis on fibroid development. There are most likely several factors involved: 1) A genetic predisposition, 2) hormones (including those of environmental origin), and 3) growth factors. Risk factors also include: obesity, diabetes, nulliparity, hypertension, and being of African American descent. Click here for the comparative pathology.
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