Answer 1: C. t(X;18)
Answer 2: C. Synovial sarcoma, biphasic type
A 37-year-old man presented with a mass in his right ankle. Resection of the mass was performed.
Comment: Synovial sarcomas are uncommon tumors more often seen in soft tissues. However, synovial sarcomas have been described almost everywhere in the human body. The tumors are more common in young adults.
Histologically, there are 3 types: Biphasic type (illustrated in this quiz), monophasic spindle-cell type, and monophasic epithelial type. By cytogenetics and molecular genetics, the common translocation is t(X;18)(p11;q11).
The treatment for these tumors appears to be complete surgical resection with adjuvant treatment. The prognosis regarding survival is variable from 36% to 76% at 5-years.
