Meningiomas originate from meningothelial cells and are more common in adults, although they have been described in the pediatric age group. Anatomically, they occur more often in the intracranial meninges, and the symptoms may depend on the size of the expanding mass.
Several histological features have been described for these tumors. Depending on their histological features they have been classified in grades ranging from I to III. Immunohistochemically, the tumors show common expression for epithelial membrane antigen and vimentin. However, other immunohistochemical markers have also shown to be positive in some tumors. Inactivation of the NF2 gene on chromosome 22q12 has been found in many cases.
Complete surgical resection is the treatment of choice. However, the prognosis of these tumors depends on several other parameters including histological features, tumor location, and extent of resection. These tumors can metastasize or recur locally.
1. Perry A, Stafford SL, Scheithauer BW, et al. Meningioma grading: an analysis of histologic parameters. Am J Surg Pathol. 1997;21:1455-1465.PubMed