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Chronic Shoulder Pain and Fingernail Clubbing in a Middle-Aged Man

By Brady Pregerson, MD | April 6, 2012
Dr Pregerson is a staff emergency physician at Cedars-Sinai Medical Center in Los Angeles and Tri-City Medical Center in Oceanside. He is the author of the Tarascon Emergency Department Quick Reference Guide, the A to Z Pocket Pharmacopoeia, and Quick Essentials: Emergency Medicine. He is also Editor-in-Chief of EMresource.org, a free online medical education Web site for emergency medicine and urgent care practitioners.

Answer: Nail Clubbing Secondary to Lung Cancer

Chronic shoulder pain with recent onset of fingernail clubbing can be an ominous sign, in this case heralding the presence of lung cancer. Lung tumors, especially Pancoast tumors, not infrequently mimic musculoskeletal conditions of the shoulder. Consider adding a chest film to the workup of shoulder pain in the proper clinical setting or when there are no positive findings on examination of the shoulder. 

Table 1 lists the differential diagnostic considerations of shoulder pain. Table 2 offers some useful tips about fingernails.

(MORE: Glomus Tumor (Glomangioma and Nonchromaffin Paraganglioma))

It is uncertain whether this patient also had tendinitis: visceral conditions, including coronary artery disease can occasionally aggravate preexisting musculoskeletal conditions. Therefore, be wary of ending your diagnostic process prematurely when a second condition may be present. Chest films for this patient show a pulmonary mass at the right hilar area (Figure 2).

Table 1. Quick essentials on shoulder pain differential diagnosis

Anterior: Acromio-clavicular joint arthritis, glenohumeral joint arthritis, biceps tendinitis

Posterior: Neck conditions, suprascapular nerve entrapment

Lateral: Impingement, tendinitis, rotator cuff  (all usually aggravated by reaching overhead)

Other: Brachial plexus, vascular disease, thoracic outlet syndrome, lung tumor, myocardial infarction, abdominal aortic aneurysm, pericarditis, GI disease 

 

Table 2.Quick essentials on fingernail conditions

Fingernails: Made of keratin. Average growth rate: 3 mm/mo for fingers; 1 mm/mo  for toes

White lines: Muehrcke lines: low albumin; Mees lines: arsenic; nail base lines: paraneoplastic disease

Fungus: Trichophyton rubrum infection in 90%. Risks: tight shoes, peripheral vascular disease, HIV infection, tobacco. Rx: terbinafine(Drug information on terbinafine) (≈ 45% relapse at 3 years)

Clubbing: "CLUB": Congenital, Cardiac, Cirrhosis, Lung disease, Ulcerative colitis, Biliary disease 

Other: HIV infection, hyperthyroidism

From Quick Essentials Emergency Medicine pocketbook, copyright EMresource.org

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by Jeffery May, M.D. | April 14, 2012 8:52 PM EDT

Pancoast tumor with pulmonary osteodystrophy. Horner's soon to follow, as will chemo and RT.
Jeff

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