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67-Year-Old Male Cancer Patient Presents With a Painful Erythema Involving the Face, Arms, and Chest

By Ted Rosen, MD | April 16, 2012

Professor of Dermatology at Baylor College of Medicine; Chief of Dermatology at Michael E. DeBakey VA Medical Center

References

1. Selvaag E. Clinical drug photosensitivity: a retrospective analysis of reports to the Norwegian Adverse Drug Reactions Committee from the years 1970-1994. Photodermatol Photoimmunol Photomed. 1997;23:21–23.

2. Drucker AM, Rosen CF. Drug-induced photosensitivity: culprit drugs, management and prevention. Drug Saf. 2011;34:821–837.

3. Chang CH, Chang JW, Hui CY, et al. Severe photosensitivity reaction to vandetanib. J Clin Oncol. 2009;27:el14–115.

4. Kong HH, Fine HA, Stern JB, et al. Cutaneous pigmentation after photosensitivity induced by vandetanib therapy. Arch Dermatol. 2009;145:923–925.

5. Fava P, Quaglino P, Fierro MT, et al. Therapeutic hotline. A rare vandetanib-induced photo-allergic drug eruption. Dermatol Ther. 2010;23:553–555.

6. Rousselot P, Larghero J, Raffoux E, et al. Photosensitization in chronic myelogenous leukaemia patients treated with imatinib(Drug information on imatinib) mesylate. Br J Haematol. 2003;120:1091–1092.

7. McLellan B, Kerr H. Cutaneous toxicities of the multikinase inhibitors sorafenib(Drug information on sorafenib) and sunitinib. Dermatol Ther. 2011;24:396–400.

8. Cohen AD, Mermershtain W, Geffen DB, et al. Cutaneous photosensitivity induced by paclitaxel(Drug information on paclitaxel) and trastuzumab(Drug information on trastuzumab) therapy associated with aberrations in the biosynthesis of porphyrins. J Dermatolog Treat. 2005;16:19–21.

9. Akay BN, Unlu E, Buyukcelik A, et al. Photosensitive rash in association with porphyrin biosynthesis possibly induced by docetaxel(Drug information on docetaxel) and trastuzumab therapy in a patient with metastatic breast carcinoma. Jpn J Clin Oncol. 2010;40:989–991.

10. Cohen PR. Photodistributed erythema multiforme: paclitaxel-related, photosensitive conditions in patients with cancer. J Drugs Dermatol. 2009;8:61–64.

11. Buesa JM, Gracia M, Valle M, et al. Phase I trial of intermittent high-dose dacarbazine(Drug information on dacarbazine). Cancer Treat Rep. 1984;68:499–504.

12. Serrano G, Aliaga A, Febrer I, et al. Dacarbazine-induced photosensitivity. Photodermatol. 1989;6:140–141.

13. Breza TS, Halprin KM, Taylor JR. Photosensitivity reaction to vinblastine(Drug information on vinblastine). Arch Dermatol. 1975;111:1168–1170.

14. Wyatt AJ, Leonard GD, Sachs DL. Cutaneous reactions to chemotherapy and their management. Am J Clin Dermatol. 2006;7:45–63.

15. Falkson G, Schulz EJ. Skin changes in patients treated with 5-fluorouracil. Br J Dermatol. 1962;74:229–236.

16. Huang V, Anadkat M. Dermatologic manifestations of cytotoxic therapy. Dermatol Ther 2011;24:401–410.

17. Horio T, Murai T, Ikai K. Photosensitivity due to a fluorouracil(Drug information on fluorouracil) derivative. Arch Dermatol. 1978;114:1498–1500.

18. Horio T, Yokoyama M. Tegafur(Drug information on tegafur) photosensitivity: lichenoid and eczematous types. Photodermatol. 1986;3:192–193.

19. Willey A, Glusac EJ, Bolognia JL. Photoeruption in a patient treated with capecitabine(Drug information on capecitabine) (Xeloda) for metastatic breast cancer. J Am Acad Dermatol. 2002;47:453.

20. Tsoussis S, Vourliotaki I, Ekonomidou F, Apostolakis S. Capecitabine as an alternative in a case of fluorouracil-induced photodermatitis. Clin Oncol (R Coll Radiol). 2006;18:158–159.

21. Hird AE, Wilson J, Symons S, et al. Radiation recall dermatitis: case report and review of the literature. Curr Oncol. 2008;15:53–62.

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TOPIC INDEX

Cancer Types
Breast Breast (HER2+) Breast (Triple-Negative) CML Colorectal Gastrointestinal GIST Genitourinary Gynecologic Head & Neck	Hematology Kidney (Renal Cell) Leukemia Lung Lymphoma Melanoma Multiple Myeloma Ovarian Prostate Sarcoma
Supportive Care	More Topics
Bone Metastases End-of-Life Care Palliative Care	Ethics in Oncology Practice Management Practice & Policy

All Topics