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A 61-year-old male with a 3-month history of cough. Mass found in lung and excised. Click here to see the whole slide image.
Click here for the comparative pathology.
C. Small-cell carcinoma
This was originally diagnosed as a small-cell carcinoma of the lung. However, the cells exceed the size criteria of scanty cytoplasm and a diameter no more than three resting lymphocytic nuclei. The cytoplasm is also abundant. A panel of experts classified this as a small-cell carcinoma of the lung, intermediate grade. The case illustrates the ambiguity in some of our diagnostic criteria.
This Image IQ has been provided by the Center for Genomic Pathology
1. Travis WD. Lung tumours with neuroendocrine differentiation. Eur J Cancer. 2009;45 Suppl 1:251-266. Review. PubMed PMID: 19775623.
2. den Bakker MA, Willemsen S, Grnberg K, et al. Small cell carcinoma of the lung and large cell neuroendocrine carcinoma interobserver variability. Histopathology. 2010;56:356-363. PubMed PMID: 20459535.