A 58-year-old man presented with symptoms of abdominal pain of several weeks duration. At physical evaluation, jaundice and ascites were present. In addition, a palpable mass was identified in the right upper quadrant. Surgical resection was performed.

A 45-year-old woman presented with severe back pain. After radiological and physical examination, the patient was found to have nephrolithiasis with marked hypercalcemia. In addition, a palpable mass in the right side of the neck was encountered. Surgical resection of the mass was performed.

A 67-year-old Caucasian male presents in the month of April with a spontaneously painful and tender-to-the-touch erythema involving the face, dorsal and distal forearms, dorsal hands, and V-area of the neck/anterior chest. He has cancer and is being treated with one or more chemotherapeutic agents.

A 3-year-old child was brought to the physician’s office after the mother felt a mass in the abdominal area. Imaging revealed the presence of a mass that appeared to be in the right kidney. Surgical resection of the tumor was performed.

A 43-year-old woman presented with intermittent pain and muscle weakness in the right side of her neck. At physical examination, a large mass was found in the parotid region. Parotidectomy was performed.

A 30-year-old man presented with pain and testicular swelling of his right testicle. The patient has not experienced any trauma, and states that otherwise he feels in good health.

A 37-year-old man presented with a mass in his right ankle. Resection of the mass was performed. What is the most likely result of a molecular study, and based on the histological and molecular features of this tumor, what is you diagnosis?

As an avid gardener, the patient spent considerable time outdoors and had never before experienced a similar problem. However, during the prior two spring-summer seasons. Almost every witnessed mosquito bite resulted in either a swollen, pruritic nodule or a substantial blister. This patient most likely has what underlying disease?

An 18-year-old man presented with cough and dyspnea of several weeks duration. The patient does not have any previous significant medical history and had been well until the cough began. Radiographic imaging revealed the presence of a tumor in the main-stem bronchus. Surgical resection of the mass was performed.

A 67-year-old African American female presented with an approximately 18-month history of a solitary, asymptomatic lesion on the right leg. This patient most likely has what tumor on her leg?

A 68-year-old woman presented with a mass on the scalp which had been present for approximately 7 years. An incisional biopsy of the scalp mass and excisional biopsy of the lymph node both revealed basal cell carcinoma, micronodular histologic subtype.

A 28-year-old, slightly obese Caucasian woman presented with a long-standing history of intermittently painful “bumps” on both shoulders and her upper back. Review of systems disclosed regular but very heavy menstrual periods, often lasting for 7 to 9 days, and chronic constipation.

A 46-year-old woman presented for medical evaluation due to a 2-month history of increasing difficulty in ambulation, especially getting up out of a chair or climbing stairs. She had also noticed swelling and discoloration of both upper eyelids (as depicted).

A 48-year-old African American female presents with severe uterine bleeding. She states that she has been bleeding very heavily for the past two days and the flow is increasing. She is also diabetic and hypertensive. Pelvic examination revealed an enlarged irregularly shaped uterus. A large mass was noted by ultrasonography and the uterus was removed. A section of the mass is evaluated.

A 60-year-old woman developed metastatic renal cell carcinoma and was given oral sorafenib. Three weeks after commencing treatment, the patient became febrile without signs of localized infection and rapidly developed a nonpruritic, slightly tender cutaneous eruption.

A 41-year-old male carrying the diagnosis of Peutz-Jeghers syndrome complains of upper abdominal pain radiating to the back and a 15-pound weight loss. Laboratory studies and imaging prompt surgery.

A 29-year-old man was presented early in this series as an example of stage IV, poorly differentiated malignant melanoma. As noted previously, evaluation disclosed the presence of multifocal metastatic disease (lungs, lymph nodes).

A 22-year-old female collegiate soccer player complains of a painful palpable area in her right breast accompanied by a straw-colored nipple discharge. Because she is extremely anxious and has had previous excisional biopsies, you decide to perform a lumpectomy.

A 56-year-old man with renal cell carcinoma developed widely metastatic disease post nephrectomy, for which he was receiving cyclic sunitinib therapy (50 mg daily for 4 weeks, followed by a 2-week rest period). Toward the end of his second cycle of therapy, he developed minimally pruritic, bright red erythema and fine scale involving both sides of the scrotum.

A 17-year-old female carries a diagnosis of Li-Fraumeni syndrome (a rare autosomal dominant syndrome) and presents with a large mass in the right shoulder. The mass is excised.

A 58-year-old man developed acute myeloid leukemia. After responding to remission-induction high-dose chemotherapy, he received an allogeneic stem cell transplant that was complicated by a graft-versus-host reaction. While being treated for the latter with prednisone, tacrolimus (Prograf), and mycophenolate mofetil (CellCept), he developed both fungal pneumonia and osteomyelitis caused by Fusarium species.

A 7-year-old girl with hereditary multiple exostosis presents with a growing painful mass on her right femur. The following is an H&E stained slide of the mass.

A 68-year-old man developed hepatocellular carcinoma associated with chronic alcohol abuse and cirrhosis. He began to receive sorafenib (400 mg twice daily) as management for advanced disease. About 8 weeks after drug initiation, the patient noted the rapid onset of two nodules nearly identical in appearance.

A 58-year-old male presents with chief complaints of bloating, vague abdominal pain, and dark black stools. He is referred to a gastroenterologist who recommends upper and lower endoscopy.

A 2-year-old girl being treated for acute lymphoblastic leukemia develops a low-grade fever and two hemorrhagic bullae in the groin.