Looking at Lymphoma on a Cellular Level

In classical Hodgkin lymphoma, Reed-Sternberg cells (HRS) play a large part in refractory or progressive disease, but studying these giant cells has proven difficult. Canadian researchers may have solved that problem by identifying target genes with expression levels that significantly correlated with genomic changes in primary HRS cells. They hypothesize that this macrophage-like signature in HRS cells could have a meaningful link to the pathobiology of treatment failure.  

RESULT: Gene expression profiling of microdissected Hodgkin Reed-Sternberg cells correlates with treatment outcome in classical Hodgkin lymphoma
Blood | Oct 25, 2012 (FREE FULL TEXT)

Recent research in lymphoma has zeroed in on better treatment pathways and immunotherapy in particular. In a review article, a multidisciplinary group in France offer a primer on the cell lines and murine models that are used to study lymphomagenesis, the lymphoma microenvironment, and the efficacy of new therapies.

RESULT: Murine Models of B-Cell Lymphomas: Promising Tools for Designing Cancer Therapies Advances in Hematology | Dec 1, 2012 (FREE FULL TEXT)