Lung Cancer

This review will describe the well-known use of VEGF antibodies; the current uses of EGFR and ALK tyrosine kinase inhibitors; newer agents being used against MET, FGFR, and other intracellular targets; insights regarding the field of immunotherapy in lung cancer; and finally, newer developments in chemotherapy.
• Lessons From Considering the Cancer Landscape
• Adapting to the Brave New World of Lung Cancer Treatment

Here we examine recent advances in the knowledge of this severe and heterogeneous malignancy, and we analyze the clinical significance of prognostic factors.
• Clinicopathologic Indices Can Improve Patient Selection
• Clinical and Pathological Features Are Still the Best Determinants of Prognosis

This review considers the status of the different histological classifications thus far presented for thymomas and offers an analysis of the association between histology and clinical behavior.
• Thymomas: A Continuing Challenge
• Controversies in the Pathology of Thymoma Viewed Through the Prism of Evidence-Based Pathology

Chemotherapy is now employed in earlier-stage disease in neoadjuvant, adjuvant, and combined-modality treatments. The aim of this article is to review the current systemic treatments for NSCLC.
• Contemporary Issues in NSCLC
• Evolving and Expanding Treatment Options in NSCLC

In this review, the authors discuss past attempts at lung cancer screening, the results of the National Lung Cancer Screening Trial, and innovative tests for lung cancer screening currently being evaluated.
• Formidable Challenges Ahead for Lung Cancer Screening
• Lung Cancer Screening: A New Era

A 49-year-old woman insidiously developed spotty depigmentation of the chest along with thickened and bound-down skin of the upper torso. In addition, all of her fingers were swollen and her facial skin became so tight that she had difficulty smiling. What is her diagnosis?

A 71-year-old man with a smoking history of more than 100 pack-years developed non–small-cell carcinoma of the lung. During his an infusion of vancomycin he developed flushing, followed by widespread fixed erythema, muscular spasms in the back, and transient but severe hypotension. Can he ever receive vancomycin again?

A 34-year-old woman presents with pain in her left chest. Radiographic imaging shows the presence of nodules in the pleural surface. Surgical excision is performed. What is your diagnosis?