RESEARCH REPORT Leah Lawrence The FTO gene, which prior research has shown is strongly associated with obesity and body mass index (BMI), contains variants associated with an increased risk for malignant melanoma, according to the results of a genome-wide association study conducted by the GenoMEL consortium.
RESEARCH REPORT Leah Lawrence The MEK inhibitor MEK162 is the first agent to show some activity in patients with NRAS- and BRAF-mutated advanced melanoma, according to the conclusions of a phase II study, evaluating the drug’s safety and efficacy.
REVIEW ARTICLE Sabino Zani, Bryan M. Clary; ONCOLOGY Vol. 25 No. 12 With the potential for therapeutic durability and a small chance of cure, surgical resection may offer improved survival compared to other therapeutic modalities. This review summarizes the existing literature that addresses the topic of metastasectomy in patients with melanoma and breast cancer.
REVIEW ARTICLE Sasha O. Joseph, Franco M. Muggia; ONCOLOGY Vol. 26 No. 10 We describe areas where major inroads were initially achieved by targeting angiogenesis and by unraveling pathways in the heterogeneous tumors of mesenchymal origin.
We describe areas where major inroads were initially achieved by targeting angiogenesis and by unraveling
pathways in the heterogeneous tumors of mesenchymal origin—spurred by the identification of c-Kit–activating
mutations in GIST and the regressions that ensued when tumors harboring these mutations were exposed to the
tyrosine kinase inhibitor imatinib (Gleevec).
• Improving Harmonious Precision • Targeted Therapy for Cancer: Asking the Right Questions
In-Transit Melanoma: An Individualized Approach Travis E. Grotz, MD1, Aaron S. Mansfield, MD2,3,
Lisa A. Kottschade, CNP2,3,
Lori A. Erickson, MD4,
Lori A. Erickson, MD5,
Svetomir N. Markovic, MD, PhD2,3,
James W. Jakub, MD1, December 30, 2011
A 3-year-old child is evaluated for leukocoria (white pupil) of the right eye. Ophthalmic evaluation revealed the presence of a mass behind the lens. Surgical removal of the right eye was performed. What is your Diagnosis?
In this podcast we discuss the recent advances in the management and treatment of metastatic melanoma with Jeffrey Sosman, MD, medical oncologist and director of the Melanoma and Tumor Immunotherapy Program at the Vanderbilt-Ingram Cancer Center in Nashville, Tennessee.
Five Steps to Improving Patient Access Judy Capko, May 21, 2013 Patient access is getting increased attention through reform initiatives. Here are five steps you can take to make sure patients get appropriate access to care in your office.