A.P. Pharma submits anti-nausea drug for FDA approval
APF530 is undergoing regulatory review for a new drug approval for the prevention of chemotherapy-induced nausea and vomiting, according to manufacturer A.P. Pharma. PF530 is a formulation of granisetron, a 5-HT3 antagonist. More »
Ginger quells chemotherapy-related nausea
ORLANDO—Ginger has been used for years to treat gastrointestinal upset, but for the first time, a large double-blind multicenter randomized study has shown ginger supplements can successfully stem chemotherapy-related nausea, University of Rochester in New York investigators reported at ASCO 2009 (abstract 9511). Some 70% of patients experience nausea and vomiting related to chemotherapy. While vomiting can largely be prevented with anti-emetics, nausea is typically more difficult to prevent and... More »
ProStrakan offers patch to prevent nausea and vomiting
Sancuso (granisetron transdermal system) is now available by prescription in the U.S. for patients with chemotherapyinduced nausea and vomiting. The patch continuously releases granisetron into the bloodstream for up to five consecutive days. More »
FDA Approves Oral Palonosetron for Prevention of Acute Chemotherapy-Induced Nausea and Vomiting
The US Food and Drug Administration (FDA) has approved a new oral formulation of palonosetron hydrochloride (Aloxi) for the prevention of chemotherapy-induced nausea and vomiting (CINV). Oral administration of palonosetron capsules is indicated for the prevention of acute nausea and vomiting following initial and repeat courses of moderately emetogenic chemotherapy. A single 0.5-mg palonosetron capsule is administered approximately 1 hour prior to the start of chemotherapy. More »
Woman With Edema, Vomiting, and Diarrhea
A 22-year-old woman has had chronic nausea, emesis with green vomitus, and diarrhea for the past 10 months. The diarrhea is frequent (about 3 to 8 times daily) and does not resolve with starvation. More »
Middle-Aged Man With Light-Headedness, Nausea, and Palpitations
A 44-year-old man presents to the emergency department (ED) with light-headedness, nausea, and vomiting of 1 day's duration. He has also had intermittent palpitations but denies chest pain, dyspnea, and weakness. More »
Antiemetic Therapy: Much Progress, Much More to be Done
A review of "Chemotherapy-Induced Nausea and Vomiting: Which Antiemetic for Which Therapy?" More »
Chemotherapy-Induced Nausea and Vomiting: Great Achievements but Room for Improvement
A review of "Chemotherapy-Induced Nausea and Vomiting: Which Antiemetic for Which Therapy?" More »
Chemotherapy-Induced Nausea and Vomiting: Which Antiemetic for Which Therapy?
Chemotherapy-induced nausea and vomiting (CINV) remains an important and common toxicity of cancer treatment. Recent guideline revisions have classified chemotherapeutic agents into four categories of emesis risk without the use of preventive agents: high (> 90%), moderate (30%-90%), low (10%-30%), and minimal (< 10%). Currently available antiemetic agents, including corticosteroids, 5-hydroxytryptamine (HT)3 receptor antagonists, and neurokinin (NK)-1 antagonists are used alone or in... More »
Major Advances and Alternative Approaches to Antiemetic Therapy
A review of "Chemotherapy-Induced Nausea and Vomiting: Which Antiemetic for Which Therapy?" More »
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