CHICAGO—Based on their initial experience with 3D digital breast tomosynthesis, radiologists at Dartmouth Hitchcock Medical Center and Dartmouth Medical School believe the investigational technique "is closer to the truth than standard mammography," Steven Poplack, MD, associate professor of diagnostic radiology and obstetrics and gynecology, said at the 2005 meeting of the Radiological Society of North America (abstract SSG01-05).

Describing one of five cases of malignancy in a study of 98 women who underwent digital breast tomosynthesis after an abnormal mammogram, Dr. Poplack noted that conventional mammograms showed an area of asymmetry with architectural distortion, which is consistent with a suspicious mass. The corresponding tomosynthesis images showed the abnormality in much greater detail, including the shape and the anatomical features at the margins of the lesion, which allowed the radiologists to characterize the mass as almost certainly an invasive breast cancer.

The tomosynthesis image also revealed a darker gray area within the tumor, which is an unusual finding in a breast malignancy and is commonly associated with fat. The pathological slide of the tumor confirmed the presence of fat surrounded by malignant cells.

"Tomosynthesis better reflects what is really going on in the breast than conventional mammography is able to do. That will hopefully translate into more accurate diagnosis," Dr. Poplack said.

With standard mammography as well as digital breast tomosynthesis, the breast is placed under compression and exposed to x-rays. The difference with 3D tomosynthesis is that the x-ray tube moves across the breast in an arc, and the machine takes a series of low-dose miniexposures. Data from a tomosynthesis examination are reconstructed into thin sections, which may be displayed in individual single scans or as a fly-through movie of image after image.

The study, sponsored by Hologic, Inc., included women who had abnormal digital screening mammograms and required additional diagnostic work-up: 98 women were included, and 99 breasts were examined. As many as three tomosynthesis views were obtained on each woman, corresponding to the views that had been obtained with diagnostic mammograms. Tomosynthesis images were reviewed prospectively by one of two breast imaging specialists, and the images were compared with diagnostic mammograms.

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