BARCELONA, Spain—In a phase I study, 70% of small-cell lung cancer patients with extensive disease had objective responses when given carbo-platin (Paraplatin) and epirubicin(Drug information on epirubicin) (Ellence) in combination.
Conducted by the Spanish Lung Cancer Group, the study was designed to discover whether the combination was active against the disease in a clinical setting and to determine the maximum tolerated dose, reported Bartomeu Massuti Sureda, MD.
Dr. Massuti, chief of the Medical Oncology Department, Alicante University Hospital, Barcelona, noted that the study followed a randomized phase III trial showing a combination of cisplatin(Drug information on cisplatin) and epirubicin to be at least as effective as cisplatin and etoposide(Drug information on etoposide) without increasing toxicity. Also conducted by the Spanish Lung Cancer Group, that trial involved more than 400 patients.
Rationale for Study
A rationale for the most recent study, Dr. Massuti told ONI, was that combining the anthracycline epirubicin with carboplatin(Drug information on carboplatin) might be even better tolerated. An aim, he added, was to “design more convenient schedules for the patient with extensive disease, because in these patients cure is not possible, and carboplatin offers a more convenient toxicity profile than cisplatin.”
The maximum tolerated dose turned out to be carbo-platin at AUC 6 and epirubicin 100 mg/m² administered intravenously on day 1 of 21-day cycles. All six regimens tested followed the same cycle pattern and combined carboplatin at either AUC 5 or AUC 6 with three different dosages of epirubicin—75, 90, and 100 mg/m².
A total of 30 patients were enrolled in the study, 28 males and 2 females, with a mean age of 63 years. To be eligible, patients had to have extensive disease with at least one metastatic lesion, no prior chemotherapy, adequate renal, hepatic, and bone marrow function and a life expectancy of 3 months or more. The most frequent site of metastatic disease was the liver; 16 patients had liver lesions. The median performance status was 80 on the Karnofsky Index.
Nine of the 30 patients (30%) had complete responses, and 12 (40%) had partial responses, Dr. Massuti reported. “Only 2 out of 30 patients progressed during the first cycle.” The number of cycles of treatment per patient ranged from 1 to 6, with the total being 103.
Dose-Limiting Toxicities
Among the six patients receiving the lowest dosages of both drugs, carboplatin AUC 5 and epirubicin 75 mg/m², one developed grade 3 mucositis, which was considered dose limiting. When epirubicin was increased to 90 mg/m² but carboplatin held at AUC 5, two of six patients showed dose-limiting toxicities, one septic shock and the other grade 4 thrombocytopenia. Two of the six patients given epirubicin 100 mg/m² and carboplatin AUC 5 developed dose-limiting neutropenia, one grade 3 and the other grade 4.
None of the three patients given carboplatin AUC 6 and epirubicin 75 mg/m² had dose-limiting toxicities. Among the six whose epirubicin dosage was 90 mg/m², one required a treatment delay of more than 7 days and another suffered neutropenic fever and grade 4 neutropenia, Dr. Massuti reported. At the highest dose level for both drugs, he added, “two out of three patients showed dose-limiting toxicities.”
Weekly analyses of blood counts during the first two cycles of treatment revealed no cumulative toxicity, Dr. Massuti said, “but myelotoxicity increased along with dose level.” Grade 4 neutropenia, he added, was the median at the two highest dosage levels.
Phase II Study Beginning
A phase II study to look at time to disease progression and survival rates will begin this fall at the 14 centers in the Spanish Lung Cancer Group, Dr. Massuti told ONI. The dosage to be tested will be carboplatin AUC 6 and epirubicin 90 mg/m², or one level below the maximum tolerated dose in the phase-I study, with both again given on day 1 of 3-week cycles.
