BETHESDA, Md--A new NCI study will evaluate three techniques to manage atypical squamous cells of undetermined significance that show up on Pap smears, including their cost effectiveness and acceptability to women.
The trial will evaluate colposcopy; repeating Pap smears every six months; and human papillomavirus (HPV) testing as a means to differentiate between abnormalities that need immediate colposcopy and those that can best be followed with repeat Pap tests at six-month intervals.
The study enrollment of 7,200 women with mild Pap test abnormalities should be completed next year. Participants will be followed for three years. The study centers are the University of Alabama at Birmingham, University of Oklahoma, Magee-Womens Hospital, and the University of Washington.