Bench and mouse studies have shown that the Notch1 gene is a crucial contributor to tumorigenesis in non-small-cell lung cancer (NSCLC). It aids tumor initiation by suppressing apoptosis, or programmed cell death, which is regulated by p53.
Results of the PrefHer study indicated that when given the option between subcutaneous trastuzumab and intravenous trastuzumab, significantly more patients with HER2-positive breast cancer preferred the subcutaneous administration.
A randomized phase III trial of adjuvant gefitinib in patients with completely resected non–small-cell lung cancer (NSCLC) was closed early, but available results suggest that the drug is unlikely to benefit this group of patients.
Prostate tumors may not readily evolve from low to high grade, according to a new study. The results have important clinical implications for patients and clinicians when choosing active surveillance or treatment.
Researchers have demonstrated that a two-step screening test can identify ovarian cancer early, before the disease progresses to an advanced, poor prognosis stage.
Among non–small-cell lung carcinoma (NSCLC) patients, foreign-born Hispanics show less cancer-related mortality compared with US-born Hispanics and non-Hispanic whites, in part due to social and cultural environment, according to results of a new study.
Maintenance therapy with rituximab showed some improvement over observation, though it did not reach significance, among older patients with advanced follicular lymphoma who responded to a brief chemoimmunotherapy induction regimen followed by rituximab consolidation therapy.
A phase I study showed that azacitidine priming followed by standard chemotherapy could be an effective approach to resistance in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL).
Researchers in China have found that the use of [18F] fluorodeoxyglucose PET/CT detected a greater number of distant metastases than conventional work-up imaging in patients with nasopharyngeal carcinoma.
The Center for Medicare and Medicaid Services is inviting physicians to comment on a proposal to make individual physician payment data accessible to the public.