Metastatic Renal Cell Carcinoma
10 mg/kg IV every 2 weeks with interferon alfa
Glioblastoma
10 mg/kg IV every 2 weeks
Metastatic Colorectal Cancer
5 mg/kg IV every 2 weeks with bolus-IFL (irinotecan plus 5-FU, leucovorin); 10 mg/kg IV every 2 weeks with
FOLFOX4 (oxaliplatin [Eloxatin], leucovorin, 5-FU)
Nonsquamous Non-small-cell Lung Cancer (NSCLC)
15 mg/kg IV every 3 weeks with carboplatin(Drug information on carboplatin)/paclitaxel
Metastatic Breast Cancer
10 mg/kg IV every 2 weeks with paclitaxel
Adverse Reactions to Bevacizumab(Drug information on bevacizumab) by Body System (boldface type indicates more common events, and effects are influenced by any concomitant chemotherapy)
CNS: Dizziness, headache, rare reversible posterior leukoencephalopathy syndrome
CV: Hypertension, congestive heart failure (rare)
ENT: Epistaxis, rhinitis, lacrimation disorder
GI: Diarrhea, constipation, GI perforation, rectal hemorrhage (rare), stomatitis, taste alterations
GU: Proteinuria, nephritic syndrome (rare)
Hematologic: GI hemorrhage, deep vein thrombosis, neutropenia, leucopenia, arterial thrombotic events, rare pulmonary embolism
Musculoskeletal: Myalgia
Reproductive: Potential for fetal harm
Respiratory: Dyspnea, upper respiratory infection
Skin: Dry skin, exfoliative dermatitis
Other: Asthenia, abdominal pain, rare infusion reactions
