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Psychiatric Times.
 

DSM-5: If You Don't Like the Effects, Look at the Causes

The Problems of DSM-5 Were Caused by DSM-III and DSM-IV

By S. Nassir Ghaemi, MD, MPH | January 17, 2013
Dr Ghami is Professor of Psychiatry at Tufts University School of Medicine, Boston, and Director of the Mood Disorders Program at Tufts Medical Center.

This post is a response to DSM 5 Is Guide Not Bible—Ignore Its Ten Worst Changes by Allen J. Frances, MD.

The former leader of DSM-IV doesn't like the effects of DSM-5. This is rather like a Freudian criticizing a Jungian: DSM-IV and DSM-5 are variations on a theme. Here is important context: The former leadership of DSM-IV, adamant in its critique of DSM-5's problems, is completely committed to the cause of those failures.

(NB: I had not commented on this matter for over 2 years in the Psychology Today website because of the uncollegial nature of the discussion. I take no pleasure in controversy and rebuttals. But, since the topic is undeniably important, I write to provide context for readers who have not already made up their minds.)

In earlier discussions, it is clear that the leadership of DSM-IV, and of DSM-III before it, views psychiatric diagnosis in the DSM system as something that should be based on “pragmatism.” This means making practical judgments about what is best for the psychiatric profession, first of all, and then for social, economic, or other reasons. We should change criteria, said my colleague explicitly, so that clinicians should be induced to use more or less of some medications (such as antipsychotics, less, versus antidepressants, more) based on the beliefs of the leadership of the DSM task forces about the risks and benefits of those medications.

It is exactly this “pragmatism” that is the root of the problems of DSM-5. If you don’t like DSM-5, you shouldn’t like DSM-IV. Here's why:

A member of the DSM-IV task force told me that the leader of DSM-IV addressed the members of a subgroup and said that in addition to their scientific evaluation of the material there, they should keep in mind 3 overriding principles:

(1) To make no changes unless the scientific evidence was extremely strong (ie, DSM conservatism).

(2) To make no changes that would lead to radical changes in the document (DSM conservatism again), and

(3) To make no changes that would harm insurance reimbursement to clinicians (economics).

Perhaps the former leader of DSM-IV can confirm publicly if these were his instructions. If so, we can see that science plays second fiddle in DSM revisions. Conservatism—not wanting to make changes for the sake of not wanting to make changes—and economics come first. Perhaps this is unavoidable. DSM may be more like science policy than science. Political leaders in a profession need to make judgments based on multiple factors, and science is only one of them.

The problem is that science has become the least of them.

I can agree with my colleague about many of his specific concerns in his top ten list (on the fallacy of temper dysregulation disorder, for instance), but the larger problem is otherwise: There will always be disagreements; some of us will prefer to cut the DSM pie one way and some the other, based on various “pragmatic”—economic, social, professional—considerations. But, all hyperbole about helping patients notwithstanding, we will not help anyone. We won't succeed in identifying diseases, finding their causes, and treating them effectively, unless science becomes a much higher priority than it has been.

This is the ultimate flaw of the DSM system:

Many people, including, it seems, the leadership of DSM-IV and DSM-5, have an unconscious postmodernist ideology. They distrust science; nosology leaders (like some of the leadership of DSM-IV) often have themselves been engaged in little, if any, scientific work. “Take the experts with a grain of salt” betrays a skepticism that, partly justified, can easily become an anti-scientific cynicism. Some readers may take this view to a nihilistic extreme, as did a national NPR science reporter with whom I once spoke. If they do, they share the same postmodernist ideology that has produced the DSM-5, which they criticize.

Unless we get beyond this anti-science extremism, we cannot progress.

When the DSM leadership—whether in the 3rd, 4th, or 5th revision—gerrymanders psychiatric definitions for professional purposes, nature will not follow suit, and our biology, genetic, and pharmacology studies will be doomed to fail, as they have in the past 3 decades.

This is a much sadder reality in psychiatry today than the APA Board of Trustees approval of DSM-5.

The generation of psychiatric leadership that gave us DSM-III, DSM-IV, and DSM-5 has had its day. The future will belong to new generations of psychiatrists who, we can hope, will think for themselves, without personal commitments to these errors of the past.

(PS: “First do no harm” is a pious slogan not to be found anywhere in the Hippocratic writings. It was invented in the 19th century by a British writer. The Hippocratic phrase is: “As to diseases, try to help, or at least not harm.” By sacrificing science to “pragmatism,” all versions of DSM prevent the profession from identifying diseases, making it harder to help, and ensuring that harm will ensue.)

Editor's Note: This blog was originally published on Psychology Today at http://www.psychologytoday.com/blog/mood-swings/201301/dsm-5-if-you-dont-the-effects-look-the-causes. It is republished online here with permission. Be sure to read the following response to this post by Allen Frances, MD, in Psychology Today: "A reply to Dr Nassir Ghaemi."

 

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by Lynn and Steve Moffic | January 17, 2013 11:49 AM EST

So, it seems like you also agree that DSM 5 is premature or inappropriate, though for different reasons than Dr. Francis. Is that true? I certainly agree with your scientific recommendations.

One of the unstated reasons for its being pushed through nevertheless, as I've understood,is the economics for the APA.

Steve Moffic

by Ronald Pies | January 17, 2013 3:31 PM EST

This is an interesting and important debate, and Dr. Frances has some rejoinders to Dr. Ghaemi's piece that are worth considering--even if, in the end, one mostly disagrees with Dr. Frances's arguments.

I agree with my friend Nassir that a "post-modern"outlook on psychiatric diagnosis often leads to cynicism and nihilism--as if to say, "Nobody really knows anything about anything, and we shouldn't trust anybody!" Actually, there is a good deal of secure and well-founded scientific knowledge in psychiatry, often unappreciated even by many in the profession (not to mention the general public). At the same time, there are inevitable value judgments and existential decisions that go into creating a system of diagnosis and classification; most notably, how much "suffering and incapacity" do we want to consider as within the bounds of "normal" as distinct from the "pathological"? I am suspicious of the Platonic view that we can "carve Nature at its joints"; but I am equally opposed to the view that there is really nothing more to our diagnostic categories than "labels" for "disliked behaviors."

In Dr. Frances's rebuttal piece, referenced above, he argues that the framers of the DSM-IV were advised to keep in mind the broader implications of any changes in the diagnostic criteria; e.g., Dr. Frances argues that

"DSM has become far too important in people's lives to ignore its practical impact. Seemingly small changes can result in the mislabeling of millions of 'patients' who are then subjected to unnecessary and often harmful treatments, stigma, costs."

I agree that such factors should not be entirely ignored in creating our diagnostic classification, but we must be aware of the conceptual "traps" lurking in such a broad manifesto. For example, who decides what constitutes "mislabeling", and on what basis? Too often, "mislabeling" seems to mean, "I don't want more people diagnosed with Disorder X, because I think doing so is really bad" (for whatever reasons). Here, we get into the misleading term "false positive"--which I discuss in my articles on panic disorder and "context" in psychiatry. Furthermore, who decides what treatments are "unnecessary" or "harmful"? Should the framers of DSM-5 involve themselves in discussions of drug side effects--or, for that matter, the risks of psychotherapy? It seems to me, these are issues better dealt with in a separate treatment manual--not in the DSM deliberations. As for "stigma"--as my blogging colleague, Sandra Naiman, has pointed out, the more we buy into the notion that psychiatric diagnosis "stigmatizes" people, the more we wind up generating prejudice and suspicion toward those with psychiatric disorders. A diagnosis by itself does not create "stigma"--rather, it is society's prejudicial and discriminatory attitudes toward psychiatric diagnosis and those who receive them that cause harm to our patients.

Dr. Frances goes on to assert that

"...we should not be introducing poorly tested and overly inclusive new diagnoses (or reducing the thresholds for existing ones) when this will give an opening to the misleading and aggressive drug company marketing that already has one in five Americans taking an often unnecessary psychotropic drug."

Here, it seems to me, Dr. Frances is advocating a kind of "social engineering" program, as part of the development of our classification scheme--and in this sense, I think Dr. Ghaemi is right to argue against this
misguided notion of "pragmatism." It should not be the goal of psychiatric nosology either to reward or punish
drug companies--and certainly not to jigger our diagnostic criteria so as to create or deny "an opening" to drug companies! This debased species of "pragmatism" introduces all kinds of moral judgments into the diagnostic classification, and loses sight of the primary ethical goal of diagnosis: namely, the alleviation of suffering and incapacity among those who seek our help.1

Ronald Pies MD

1. Pies R: Toward A Concept of Instrumental Validity: Implications for Psychiatric Diagnosis. Dialogues in Philosophy, Mental and Neuro Sciences http://www.crossingdialogues.com/Ms-D11-01.pdf

by Manuel Mota-Castillo | January 27, 2013 4:36 PM EST

I watch this "Clash of the Titans"with rejoice because it could have a positive outcome for the future of a psychiatric field where specialists would formulate diagnoses based on observations, unbiased history-gathering and clinical skills. I am not an enthusiast of the American Psychiatric Association (APA) but I have been polite when I refer to this organization out of respect for the very same voices involved in this discussion and also my illustrious friend Hagop Akiskal. They all show respect for the APA and I respect them.
Even though I believe that the APA and the American Academic of C&A Psychiatry (AACAP) will have to do more explaining than those responsible for the Tuskegee experiment, I have restrained my desire to say that the APA is "guilty by omission" because many mistakes of the past should have been fixed but they failed to do so. These are some examples:
Lives that could have been productive and happy are spoiled because of misdiagnosed during childhood, i.e., the over-diagnosed ADHD and the retention of Oppositional-Defiant Disorder as a diagnosis to explain why a wrongly labeled "ADHD child" does not behave well.
The absurd use of SSRIs in patients with Borderline Personality Disorders who never improve, unless the medication is accompanied by mood stabilizers and CBT.
The negligent endorsement of prescribing antidepressants on a continue basis to patient with co-morbid PTSD (or OCD) and bipolar disorder. No even the highly publicized suicide rate among soldiers has moved the APA to take a look at this issue, from this perspective.
Closing eyes and ears to the irrational practice of diagnosing ADHD in autistic patients. Even if the DSM-IV would not ban such nonsense, simple reasoning indicates that autistic children have a clear reason for been inattentive and that another diagnosis is unnecessary. Equally scientifically-challenged is the decision to diagnose autistic children with Social Anxiety Disorder but nevertheless is happening in some of the most prestigious psychiatric training program in the USA, as can be corroborated in their podcasts. And the problem is not just misdiagnosing but, as Dr. Ghaemi accurately quoted Hippocrates, we should "at least do not harm." Stimulants, by increasing dopamine, are a poison to obsessive or nervous people.
Having the knowledge that many doctors diagnose 80 to 90% of their patients with the same disease (ADHD) and no questioning such statistical impossibility is something that leaves the APA and the AACAP in a very hard to defense position.
The list could go on and I don't want to lose the attention of the readers but I hope that more colleagues will join this discussion and maybe then the APA will take the bull by the horns.
Manuel Mota-Castillo, M.D
Lake Mary, Florida

by James OBrien | January 31, 2013 11:03 PM EST

The focus on reliability and utility is a distraction from the real problem which is construct validity. Right now there is so much comorbidity between dx it's ridiculous. Except within the same diagnosis. Two people can have dysphoria and four other different symptoms and still have the same condition and yet one can have more in common with a patient with GAD. Really? Is this the best we can do?

A fresh start would be to admit we don't really treat "mental disorders" anyway, but mental symptoms with medication and mental processes with psychotherapy.

by Neil Jeyasingam | February 04, 2013 11:57 PM EST

The debate is important, and the problems of nosology by consensus as opposed to science are very significant. I am particularly troubled by the damage to personality disorders. But perhaps my own practice is less a valid approach than a cautionary tale in its parody - I still use DSM-III.

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