Nationally, the number of drug shortages has tripled since 2005. Other generic drug shortages in our clinic have included paclitaxel, leucovorin, and doxorubicin. We have had limited ability to order fluorouracil (5-FU) and mitomycin.

This article provides a comprehensive summary of the knowledge gained from recent neoadjuvant trials conducted with agents targeting HER2, and will put them into perspective with current treatment recommendations from American and European guidelines.
• Neoadjuvant Therapy for HER2-Positive Early-Stage Breast Cancer
• Improving Therapy for HER2-Positive Cancers Through Neoadjuvant Studies

This article addresses some of the most common major challenges in oncologist-patient communication with a nuanced approach to the concepts of autonomy, paternalism, and culture.
• Autonomy Versus Paternalism in Latin America
• The Changing Scenario in Oncologist-Patient Communication
• Dealing With Ethical Dilemmas in Oncological Communication

We have entered a period of accelerated drug development and optimism in the care of advanced prostate cancer. The treatment paradigm for these patients is rapidly evolving, with future study needed to define the optimal sequencing and potential combinations of these new agents.
• Sequencing of Therapies in Advanced Prostate Cancer
• What to Order From the Prostate Cancer Treatment Menu?

The aim of this review is twofold: to summarize descriptions of the clinical presentation provided in published series in order to help clinicians recognize and treat patients, and to discuss diagnostic difficulties faced by hematopathologists when dealing with these lesions and others in the differential diagnosis that must be distinguished from one another.
• Nodal Marginal Zone Lymphoma: Impersonalized Medicine
• Nodal Marginal Zone Lymphoma: What Do We Really Know?

A 46-year-old woman presented for medical evaluation due to a 2-month history of increasing difficulty in ambulation, especially getting up out of a chair or climbing stairs. She had also noticed swelling and discoloration of both upper eyelids (as depicted).