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AIDS-related Kaposi's Sarcoma: Options for Today and Tomorrow

AIDS-related Kaposi's Sarcoma: Options for Today and Tomorrow

Prior to 1981, Kaposi sarcoma (KS) was considered a rare human cancer occurring primarily
among elderly Italian and Jewish men of eastern European ancestry. I wrote a review of KS
research and clinical experiences that appeared in CA: A Cancer Journal for Clinicians. Publication
of this article in January 1981 coincided with a dramatic upsurge in the number of cases of KS in
young homosexual males reported to the Centers for Disease Control. The general lack of
information about this disease was readily apparent when, upon publication of this article, my office
was inundated with calls from physicians requesting additional information on this disease. Later on
it was recognized that KS among young homosexual men was actually part of the clinical syndrome
seen in the epidemic of acquired immune deficiency syndrome (AIDS).

The body of clinical experience with AIDS-related KS has grown significantly over the past 15
years. This experience has led to a greater understanding of the pathogenesis of KS in general, and
angiogenesis and tumor growth factors in particular, and to the establishment of protocols for
treating patients with AIDS-related KS. Now, physicians can usually diagnose this disease on a
clinical basis, and pathologists can diagnose it with certainty on histologic grounds.

The purpose of this symposium was to review our experience with KS in patients with AIDS and
to provide an update on KS epidemiology, pathology, and clinical presentation in AIDS patients.
Current treatment options were discussed, as well as treatment modalities that are expected to be
available in the near future.

The Epidemiologic Scope of Kaposi's Sarcoma

Worldwide, there are four clinical presentations of KS--the classic form, the African form, the form
observed in transplant patients who are immunocompromised as a result of immunosuppressive
drug therapy, and the AIDS form. Dr. Haverkos discusses in detail differences in the epidemiology
and clinical presentation of these four forms of KS. Data suggest that the cause of AIDS-related
KS is multifactorial. In addition to HIV infection, it has been hypothesized that necessary or
enhancing cofactors associated with the development of this form of KS may include a genetic
predisposition, the use of nitrite inhalants, a second sexually transmitted agent, or a fecal/oral agent.
Dr. Haverkos supports this hypothesis using comprehensive epidemiologic data from the Centers
for Disease Control and his own extensive research.

Clinical Manifestations of Kaposi's Sarcoma

In my presentation I discuss the clinical manifestations of KS. We have proposed that the etiologic
factor responsible for KS is immune dysregulation, rather than immune deficiency. Epidemiologic
data further suggest that the homosexual life-style contributes to conditions necessary for the
development of this form of KS. The sexually transmissible cytomegalovirus and human
papillomaviruses have been implicated in particular. Also implicated are the potentially mutagenic
drugs, such as nitrite inhalants, that are frequently abused by AIDS patients prior to their becoming
ill.

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