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Paclitaxel as First-Line Treatment for Metastatic Breast Cancer

Paclitaxel as First-Line Treatment for Metastatic Breast Cancer

ABSTRACT: When administered as a single agent in pretreated patients with advanced breast cancer, paclitaxel (Taxol) exhibits remarkable antitumor activity. This trial was undertaken to compare paclitaxel with standard chemotherapy as front-line therapy for this disease. Patients with measurable or evaluable metastatic breast cancer, no prior chemotherapy for metastatic disease, and an Eastern Cooperative Oncology Group performance status of 0 to 2 were randomized to receive paclitaxel 200 mg/m² intravenously over 3 hours for eight cycles (6 months) or standard treatment with oral cyclophosphamide (Cytoxan) 100 mg/m²/d days 1 through 14, intravenous methotrexate 40 mg/m² days 1 and 8, intravenous 5-fluorouracil 600 mg/m² days 1 and 8, and oral prednisolone 40 mg/m²/d (CMFP) days 1 through 14 for six cycles (6 months). Patients whose disease progressed or relapsed were recommended to receive second-line epirubicin. Accrual has been completed with 208 patients randomized, but a preplanned interim analysis of the first 100 patients is reported here. Analysis of quality of life, assessed by a linear analogue scale and overall quality of life indices, is ongoing. Objective response occurred in 31% (confidence interval, 19% to 45%) with paclitaxel and 35% (confidence interval, 22% to 51%) with CMFP with stable disease in an additional 33% and 29%, respectively. Median time to progression was 5.5 months for paclitaxel-treated patients and 6.4 months for those given CMFP, with median survival durations of 17.3 and 11.3 months, respectively. Grades 3 and 4 neutropenia occurred in 64% of patients treated with paclitaxel and in 63% treated with CMFP. However, febrile neutropenia was the primary reason for hospitalization in 1% of paclitaxel courses, compared with 8% of CMFP courses. Nine percent of the patients had major infections with CMFP, but none were seen with paclitaxel. Moderate or severe mucositis occurred in 13% of paclitaxel-treated and 27% of CMFP-treated patients. Alopecia and peripheral neuropathy were more common with paclitaxel. Quality of life assessments in the first 100 patients suggest better overall results on paclitaxel treatment as compared with CMFP. Preliminary analyses suggest that single-agent paclitaxel is well tolerated and provides comparable control of metastatic cancer to CMFP combination therapy when used as front-line treatment. [ONCOLOGY 11(Suppl):19-23, 1997]

Introduction

In the United States each year, more than 180,000 women are diagnosed
with breast cancer and more than 45,000 die of the disease each year.[1]
In spite of major advances in adjuvant therapy, metastatic breast cancer
remains a major clinical problem affecting large numbers of patients.

For many years, standard-dose combination chemotherapy has been the
mainstay of therapy for metastatic disease that is hormone resistant, estrogen-receptor
negative, or associated with life-threatening or visceral disease. The
choice of initial chemotherapy has been combination cyclophosphamide (Cytoxan)/methotrexate/5-fluorouracil
(5-FU) (CMF) or CMF with prednisone (CMFP), with or without vincristine
(Oncovin) followed by anthracycline, or doxorubicin (Adriamycin)-containing
combinations.[2-4] The choice of initial chemotherapy is often complicated
by early relapse in patients who have received adjuvant chemotherapy.

CMF COMBINATION CHEMOTHERAPY

When first described by Cooper,[5] the CMF combination was reported
to induce high response rates. Modern criteria and increasingly sophisticated
imaging procedures for assessment of the extent of disease and response
have shown that the CMF regimen, with or without vincristine and prednisolone,
produces objective responses in about 37% to 59% of patients (Table
1
).[2,6-14] Perhaps more significant, median response duration ranges
from 6 to 11 months, and the median survival from initiation of treatment
ranges from 7 to 16 months.

CMF Combinations and Doxorubicin

Doxorubicin alone has been shown to be as active as CMF in randomized
studies of patients with advanced breast cancer.[2,8,15,16] In these studies,
single-agent doxorubicin produced shorter response durations than CMF,
but there was no obvious difference in survival. Survival was difficult
to interpret, however, because patients were often crossed over to the
alternative regimen on progression.

Six randomized studies of cyclophosphamide/doxorubicin/5-FU (CAF) versus
CMF in advanced breast cancer have been reviewed by Henderson.[17-23] Three
of the six showed significantly higher response rates with the CAF combination,
but only two of six showed a statistically significant survival advantage
for the doxorubicin combination.

These studies have been interpreted as showing a slight advantage for
doxorubicin combinations in treatment of metastatic breast cancer.[17]
This interpretation is controversial, and any improvement in outcome with
standard-dose doxorubicin combinations compared to CMF is likely to be
marginal.

An Australian randomized study compared doxorubicin/cyclophospha
mide (AC) with CMFP in 305 previously untreated patients with metastatic
breast cancer.[12] The response, response duration, and survival were similar
with either CMFP or AC given continuously until relapse. There also was
no difference in the effect of either regimen on life-threatening or visceral
disease. The doxorubicin combination was associated with significantly
more nausea, vomiting, and alopecia than was the CMFP combination. A quality-of-life
assessment by patients on this study revealed that the parameter measuring
nausea and vomiting deteriorated for patients on AC, but not for those
on CMFP.

This Australian trial provided a rationale for the use of CMFP as the
control arm of a phase III randomized trial of CMFP versus paclitaxel (Taxol).

PACLITAXEL IN BREAST CANCER

Paclitaxel is a novel cytotoxic agent that binds to the beta-tubulin
monomer, inducing permanent microtubular polymerization.[24,25] The resulting
loss of dynamic reorganization of microtubules during mitosis results in
selective blockade of the G2/M phase of cell division. This
action in vitro correlates with clinical activity of paclitaxel.[26]

Paclitaxel, given as a 24-hour infusion, has been found to be active
in previously treated patients with advanced breast cancer.[27] In a single-institution
study conducted at the M.D. Anderson Cancer Center, Holmes reported 6 of
11 previously treated patients responded to paclitaxel therapy with similar
responses seen in 8 of 14 patients who had prior adjuvant chemotherapy
only.[27] Of six patients who were resistant to doxorubicin, two achieved
a partial remission in response to paclitaxel. Since this initial report
there have been a number of studies and reviews confirming that paclitaxel
is active in previously treated and anthracycline-resistant breast cancer.[28-32]
The reported response rates have been quite variable, however, ranging
from 20% to 62% with similar variability in response duration.

The schedule of paclitaxel infusion also has varied, with most of the
earlier studies using 24-hour infusions. Other studies have since reported
1-hour and 3-hour infusion times.[33-35] A large, randomized European-Canadian
study compared two doses of paclitaxel (135 mg/m² vs 175 mg/m²)
and two infusion times (3-hour vs 24-hour) in patients with relapsed ovarian
cancer. In these ovarian cancer patients, there were no differences related
to the two infusion rates. The incidence of hypersensitivity reactions
was low and also was not influenced by dose or schedule. However, this
study clearly demonstrated that the 24-hour paclitaxel infusion is associated
with a significantly greater reduction in neutrophils following each course
compared to the 3-hour infusion.[33] This observation has been confirmed
by a recent randomized study comparing 3-, 6-, and 96-hour infusions of
paclitaxel.[36] Greco and Hainsworth[35] showed that 1-hour paclitaxel
infusions were safe, with the dose-limiting toxicity remaining leukopenia,
as expected.[35] Although numbers were small, approximately 35% of previously
treated patients with breast cancer responded to the 1-hour paclitaxel
regimen, at a dose of 135 mg/m². According to these data, there is
no compelling evidence that longer infusion times are associated with in
creased efficacy, at least in ovarian cancer. Those data and the convenience
of the shorter administration schedule have provided a rationale for exploration
of shorter infusion times for the treatment of breast cancer.

PACLITAXEL
VS CMFP IN UNTREATED METASTATIC BREAST CANCER

We have reported the preliminary results of a phase III randomized trial
of CMFP versus paclitaxel in previously untreated patients with metastatic
breast cancer.[37] Patients eligible for this study had measurable or evaluable
metastatic breast cancer and had had no prior chemotherapy, except for
adjuvant chemotherapy, for at least 6 months prior to study entry. No prior
radiotherapy was permitted for at least 4 weeks prior to study entry. Patients
were required to have Eastern Cooperative Oncology Group performance status
of 0 to 2, adequate bone marrow function, liver function, and renal function.
Responses and toxicity were evaluated using the criteria of the World Health
Organization (WHO),[38] and patients were required to give written informed
consent prior to enrollment.

Eligible patients were randomized to either paclitaxel or CMFP. Paclitaxel
200 mg/m² was given as a 3-hour continuous intravenous (IV) infusion
every 21 days for a total of 8 courses over 24 weeks. Standard premedication
included dexamethasone 20 mg orally (PO) 12 and 6 hours prior to therapy,
and diphenhydramine 50 mg IV and cimetidine 300 mg IV 30 minutes prior
to paclitaxel. Standard antiemetics including metoclopramide, prochlorperazine,
ondansetron, and dexamethasone were given if required.

CMFP chemotherapy was given as cyclophosphamide 100 mg/m² PO daily
on days 1 to 14, methotrexate 40 mg/m² IV on days 1 and 8, 5-FU 600
mg/m² IV on days 1 and 8, and prednisone 40 mg/m² PO daily days
1 to 14. This schedule was repeated every 4 weeks for six courses, over
24 weeks. Antiemetics were given as for the paclitaxel treatment arm. Upon
completion of 6 months of therapy, chemotherapy was stopped and patients
were observed until relapse.

Appropriate clinical assessment and imaging techniques for tumor evaluation
were carried out at baseline and at 12 and 24 weeks unless the patient
progressed clinically before that time. The routine assessments included
quality-of-life evaluations previously used and reported by this group
of investigators.[12] Patients whose disease progressed were recommended
for subsequent treatment with single-agent epirubicin.

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