Two genome-wide studies have identified a total of 12 new genetic loci associated with a higher risk of testicular cancer. The risk-associated genetic variations could help clinicians single out... More »
Testicular cancer, although an uncommon malignancy, is the most frequently occurring cancer in young men. In the year 2010, an estimated 8,480 cases of testicular cancer will have been diagnosed in... More »
This review addresses the rationale and evidence for—and the challenges, cost implications, and future development of—proton therapy as an important part of the treatment strategy in Hodgkin lymphoma. More »
Long-term neurologic and peripheral vascular toxicity after chemotherapy treatment of testicularcancer. ... Klepp O,. et al. Observational study of prevalence of long-term Raynaud-like phenomena and neurological side effects in testicularcancer
A 48-year-old male patient presented with a Pancoast tumor of the right lung and a serum alpha-fetoprotein (FP) at 39,000 ng/ml. Alpha-fetoprotein is a tumor marker found elevated in patients with hepatocellular carcinoma (HCC), germ cell or stromal tumors of the ovary and nonseminomatous testicularcancer. Occasionally, this tumor marker may rise in non-neoplastic conditions such as cirrhosis and hepatitis and only exceptionally in rare cancers with hepatoid differentiation. We present our case report and review the English literature for FP-producing lung carcinomas. To the best of our knowledge this is the first report in the literature of an FP producing Pancoast tumor.
Familial aggregation of testicular germ cell tumors (TGCT) has been reported, but it is unclear whether other cancers co-aggregate in multiple-case TGCT families. METHODS: We performed an observed-to-expected (O/E) analysis in a cohort of TGCT families with documented family cancer history assembled in Norway and the U.S. All bloodline first-degree relatives of TGCT cases were eligible. Relatives with missing vital status, gender, or dates of birth and/or death were excluded. We used population-based,
There are multiple clinical situations where cryopreservation of sperm is required including sperm banking prior to chemotherapy or radiation treatment for cancer, donor sperm for couples without a male partner, and various etiologies of male factor infertility. Bunge and Sherman presented the first pregnancy resulting from the thawing of cryopreserved sperm in 1953 (Bunge RJ, Nature 172:767-768, 1953). Since that time, cryopreservation techniques have continued to improve. Here, we describe protocols for the cryopreservation and thawing of semen and testicular tissues using a simple liquid nitrogen vapor technique.
Male germ cells in all mammals are arranged within the seminiferous epithelium of the testicular tubules in a set of well-defined cell associations called stages. The cellular associations found in these stages and characteristics of the cells used to identify the stages have been well described. Here we present a binary decision key roadmap for identifying stages and present several examples of how staging tubules can be used to better assess the developmental profile of gene expression during spermatogenesis and defects in spermatogenesis arising in pathological conditions resulting from genetic mutations in mice. In particular, when one or more cells of a cellular association cannot be clearly identified or are missing, the cell types that should be present can be precisely identified by knowledge of the approximate or exact stage of the tubule cross section.
Men around the world will be growing moustaches in the month of November to raise awareness of prostate and testicular cancers, and depression in men with cancer. The global Movember movement gets men talking about their health, combats misinformation and encourages early detection of life-threatening illnesses.