Two genome-wide studies have identified a total of 12 new genetic loci associated with a higher risk of testicular cancer. The risk-associated genetic variations could help clinicians single out... More »
Testicular cancer, although an uncommon malignancy, is the most frequently occurring cancer in young men. In the year 2010, an estimated 8,480 cases of testicular cancer will have been diagnosed in... More »
This review addresses the rationale and evidence for—and the challenges, cost implications, and future development of—proton therapy as an important part of the treatment strategy in Hodgkin lymphoma. More »
T-cell lymphomas involve the testis infrequently, which deserve special attention because of the poor prognosis and the need to make an appropriate diagnosis, which could lead to a better therapeutic strategy.|T-cell lymphomas involve the testis infrequently, which deserve special attention because of the poor prognosis and the need to make an appropriate diagnosis, which could lead to a better therapeutic strategy.
The metabolic syndrome (MS) might increase the risk of cardiovascular disease in testicularcancer (TC) survivors. We investigated its prevalence, development, vascular implications, and the role of gonadal function.
TC survivors treated with chemotherapy and follow-up ≥3 years (N = 370, study I) were retrospectively evaluated for the development of cardiovascular risk factors. A subgroup followed 3–20 years (N = 173, study I
The BJC is owned by Cancer Research UK, a charity dedicated to understanding the causes, prevention and treatment of cancer and to making sure that the best new treatments reach patients in the clinic as quickly as possible. The journal reflects these aims. It was founded more than fifty years ago and, from the start, its far-sighted mission was to encourage communication of the very best cancer research from laboratories and clinics in all countries. The breadth of its coverage, its editorial independenc
Despite high curability, some testicularcancer (TC) patient groups may have increased mortality. We provide a detailed age- and histology-specific comparison of population-based relative survival of TC patients in Europe and the USA.
Using data from 12 European cancer registries and the USA Surveillance, Epidemiology and End Results 9 database, we report survival trends for patients diagnosed with testicular seminomas and nonseminomas betwee
What's known on the subject? and What does the study add? Bilateral testicular germ cell tumours (BTGCTs) are rare neoplasms. Most previously published studies consist of case reports or small retrospective case series. Little is known about their epidemiological and clinicopathological characteristics. BTGCT corresponded to 1.82% of testicular tumours. Metachronous disease was about twice as frequent as synchronous disease. The primary tumour histology, chemotherapy use and the interval between metachronous tumours influenced the histology of the second tumour. Overall, synchronous tumours were associated with more advanced disease and presented less favourable survival rates than metachronous tumours. Testicularcancer is the most common tumour in young men. It is known that a second primary contralateral testis tumour may occur in up to 5% of men with a proior tumour. About 35% of these men present with synchronous tumours, and 65% present with metachronous tumours. However there
Central nervous system (CNS) prophylaxis for diffuse large B-cell lymphoma (DLBCL) is controversial with even less evidence in the era of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy. We reviewed the impact of CNS prophylaxis in DLBCL patients treated with R-CHOP at a tertiary care centre over a 7-year period. CNS prophylaxis was recommended for 'higher risk' patients and consisted of intrathecal methotrexate and/or high-dose methotrexate. Of 214 patients 126% received CNS prophylaxis. With a median follow-up of 27months, eight patients (37%) developed CNS relapse (75% isolated to the CNS and 625% as parenchymal brain disease) at a median time of 17months. Patients who did not receive CNS prophylaxis had lower events (27%) than those who did (111%). Half of the CNS relapses occurred in testicular lymphoma patients, 75% of whom had received CNS prophylaxis. In multivariate analysis, testicular involvement was the only significant
The discriminative ability of risk models for dichotomous outcomes is often evaluated with the concordance index (c-index). However, many medical prediction problems are polytomous, meaning that more than two outcome categories need to be predicted. Unfortunately such problems are often dichotomized in prediction research. We present a perspective on the evaluation of discriminative ability of polytomous risk models, which may instigate researchers to consider polytomous prediction models more often. First, we suggest a "discrimination plot" as a tool to visualize the model's discriminative ability. Second, we discuss the use of one overall polytomous c-index versus a set of dichotomous measures to summarize the performance of the model. Third, we address several aspects to consider when constructing a polytomous c-index. These involve the assessment of concordance in pairs versus sets of patients, weighting by outcome prevalence, the value related to models with random performance,