Oncology NEWS International Vol 12 No 5

Forward Planning IMRT Targets Tumor Bed

May 01, 2003

CHICAGO-After breast-conserving surgery, patients who receive intensity-modulated radiation therapy (IMRT) shaped to the outline of the targeted tumor bed, as determined by three-dimensional (3D) CT imaging, achieve good results with a reduced radiation dose, according to a clinical study reported at the 88th Scientific Assembly and Annual Meeting of the Radiological Society of North America (abstract 335). The technique is known as forward planning IMRT (see images).

Lymphadenectomy Indicated in Stage IA Ovarian Cancer

May 01, 2003

NEW ORLEANS-With few exceptions, lymphadenectomy should be performed in ovarian cancer patients even if they have stage IA disease. This was the conclusion of French investigators who analyzed 276 women with epithelial ovarian cancer and reported their results at the 34th Annual Meeting of the Society of Gynecologic Oncologists (abstract 94).

Antidepressants a New Option for Managing Hot Flashes

May 01, 2003

CHICAGO-A low daily dose of venlafaxine (Effexor)-an antidepressant agent that affects reuptake of serotonin and norepinephrine-resulted in a 60% reduction in the "median hot flash score," a measure of the severity and frequency of hot flashes. The therapeutic dose range for treatment of depression is 75 to 225 mg/d; the 60% reduction in the hot flash score was achieved with only 75 mg/d. Charles Loprinzi, MD, director of medical oncology, Mayo Clinic, Rochester, Minnesota, reported the results at the Lynn Sage Breast Cancer Symposium.

ER Status Predicts Response to Tamoxifen in DCIS Patients

May 01, 2003

SAN ANTONIO-A retrospective analysis of data from the National Surgical Adjuvant Breast and Bowel Project (NSABP) Protocol B-24 suggests that estrogen-receptor (ER) expression predicts response to tamoxifen (Nol-vadex) among patients with ductal carcinoma in situ (DCIS).

Predicting Complications of Laparoscopy in Gyn Patients

May 01, 2003

NEW ORLEANS-In patients undergoing laparoscopic procedures for gynecologic lesions, complications and conversion to laparotomy can be predicted based on several risk factors, according to the 10-year experience of Memorial Sloan-Kettering Cancer Center investigators, presented at the 34th Annual Meeting of the Society of Gynecologic Oncologists (SGO abstract 74).

Primary Tumor Resection Ups Survival in Stage IV Breast Ca

May 01, 2003

CHICAGO-The use of surgical resection of local disease in women presenting with metastatic breast cancer results in a statistically significant survival advantage, Seema Khan, MD, said at the Lynn Sage Breast Cancer Symposium.

NCCN Updates Colon Ca Guidelines

May 01, 2003

HOLLYWOOD, Florida-The National Comprehensive Cancer Network (NCCN) has added an oxaliplatin (Eloxatin)-containing regimen for the treatment of advanced colorectal cancer to its updated 2003 guidelines for colorectal cancer treatment, as well as new recommendations for the use of radiation therapy (see box).

Rituximab Plus Fludarabine and Cyclophosphamide Safe and Effective in Follicular Lymphoma

May 01, 2003

This special supplement to Oncology News International includes updated results of studies with anti-CD20 therapy and other targeted therapies in the treatment of lymphomas, chronic lymphocytic leukemia, and immune thrombocytopenic purpura. The results were presented at the American Society of Hematology 44th Annual Meeting in Philadelphia, December 6 to 10, 2002.

Marked Antitumor Activity Produced by Rituximab Plus Thalidomide in Mantle Cell Lymphoma

May 01, 2003

This special supplement to Oncology News International includes updated results of studies with anti-CD20 therapy and other targeted therapies in the treatment of lymphomas, chronic lymphocytic leukemia, and immune thrombocytopenic purpura. The results were presented at the American Society of Hematology 44th Annual Meeting in Philadelphia, December 6 to 10, 2002.

Substituting Liposomal for Free Vincristine in CHOP Could Permit Higher Therapeutic Doses

May 01, 2003

This special supplement to Oncology NewsInternational includes updated results ofstudies with anti-CD20 therapy and othertargeted therapies in the treatment oflymphomas, chronic lymphocytic leukemia,and immune thrombocytopenic purpura. Theresults were presented at the American Societyof Hematology 44th Annual Meeting inPhiladelphia, December 6 to 10, 2002.City Hall in Philadelphia, Pennsylvania

Adding Anti-CD20 Antibody to First-Line Chemotherapy Improves Response in Previously Untreated NHL

May 01, 2003

This special supplement to Oncology NewsInternational includes updated results ofstudies with anti-CD20 therapy and othertargeted therapies in the treatment oflymphomas, chronic lymphocytic leukemia,and immune thrombocytopenic purpura. Theresults were presented at the American Societyof Hematology 44th Annual Meeting inPhiladelphia, December 6 to 10, 2002.

Single-Agent Rituximab Is Viable Treatment Option for Patients With Lymphocyte- Predominant Hodgkin’s Disease

May 01, 2003

This special supplement to Oncology NewsInternational includes updated results ofstudies with anti-CD20 therapy and othertargeted therapies in the treatment oflymphomas, chronic lymphocytic leukemia,and immune thrombocytopenic purpura. Theresults were presented at the American Societyof Hematology 44th Annual Meeting inPhiladelphia, December 6 to 10, 2002.

Fludarabine/Cyclophosphamide/ Rituximab Combination Achieves High Molecular Remission Rate

May 01, 2003

This special supplement to Oncology NewsInternational includes updated results ofstudies with anti-CD20 therapy and othertargeted therapies in the treatment oflymphomas, chronic lymphocytic leukemia,and immune thrombocytopenic purpura. Theresults were presented at the American Societyof Hematology 44th Annual Meeting inPhiladelphia, December 6 to 10, 2002.

Rituximab Maintenance Therapy Improves Event-Free Survival and Duration of Response in Patients With Follicular Lymphoma

May 01, 2003

This special supplement to Oncology News International includes updated results of studies with anti-CD20 therapy and other targeted therapies in the treatment of lymphomas, chronic lymphocytic leukemia, and immune thrombocytopenic purpura. The results were presented at the American Society of Hematology 44th Annual Meeting in Philadelphia, December 6 to 10, 2002.

Fludarabine Followed by Alemtuzumab Produces High Response Rates in Previously Untreated CLL

May 01, 2003

This special supplement to Oncology NewsInternational includes updated results ofstudies with anti-CD20 therapy and othertargeted therapies in the treatment oflymphomas, chronic lymphocytic leukemia,and immune thrombocytopenic purpura. Theresults were presented at the American Societyof Hematology 44th Annual Meeting inPhiladelphia, December 6 to 10, 2002.

Rituximab/Alemtuzumab May Be Beneficial for Poor-Prognosis Patients With Chronic Lymphoid Malignancies

May 01, 2003

This special supplement to Oncology NewsInternational includes updated results ofstudies with anti-CD20 therapy and othertargeted therapies in the treatment oflymphomas, chronic lymphocytic leukemia,and immune thrombocytopenic purpura. Theresults were presented at the American Societyof Hematology 44th Annual Meeting inPhiladelphia, December 6 to 10, 2002.

Early Clinical Investigations of Idiotype Vaccines in the Treatment of Follicular and Mantle Cell Lymphoma

May 01, 2003

This special supplement to Oncology News International includes updated results of studies with anti-CD20 therapy and other targeted therapies in the treatment of lymphomas, chronic lymphocytic leukemia, and immune thrombocytopenic purpura. The results were presented at the American Society of Hematology 44th Annual Meeting in Philadelphia, December 6 to 10, 2002. City Hall in Philadelphia, Pennsylvania

Targeted Therapeutics Demonstrate Potential to Improve Treatment of Non-Hodgkin’s Lymphoma

May 01, 2003

This special supplement to Oncology NewsInternational includes updated results ofstudies with anti-CD20 therapy and othertargeted therapies in the treatment oflymphomas, chronic lymphocytic leukemia,and immune thrombocytopenic purpura. Theresults were presented at the American Societyof Hematology 44th Annual Meeting inPhiladelphia, December 6 to 10, 2002.

Addition of Rituximab to Combination Chemotherapy Improves Response Rates in Mantle Cell and Other Lymphomas

May 01, 2003

This special supplement to Oncology News International includes updated results of studies with anti-CD20 therapy and other targeted therapies in the treatment of lymphomas, chronic lymphocytic leukemia, and immune thrombocytopenic purpura. The results were presented at the American Society of Hematology 44th Annual Meeting in Philadelphia, December 6 to 10, 2002.

Tositumomab and Iodine I 131 Tositumomab Regimen Achieves Durable Remissions in Advanced NHL

May 01, 2003

This special supplement to Oncology NewsInternational includes updated results ofstudies with anti-CD20 therapy and othertargeted therapies in the treatment oflymphomas, chronic lymphocytic leukemia,and immune thrombocytopenic purpura. Theresults were presented at the American Societyof Hematology 44th Annual Meeting inPhiladelphia, December 6 to 10, 2002.

Targeted Therapeutics Have a Role to Play in Stem Cell Transplants in Heavily Pretreated Non-Hodgkin’s Lymphoma

May 01, 2003

This special supplement to Oncology NewsInternational includes updated results ofstudies with anti-CD20 therapy and othertargeted therapies in the treatment oflymphomas, chronic lymphocytic leukemia,and immune thrombocytopenic purpura. Theresults were presented at the American Societyof Hematology 44th Annual Meeting inPhiladelphia, December 6 to 10, 2002.

R-CHOP Improves Overall and Event-Free Survival in Patients With Aggressive or Poor Prognosis NHL

May 01, 2003

This special supplement to Oncology NewsInternational includes updated results ofstudies with anti-CD20 therapy and othertargeted therapies in the treatment oflymphomas, chronic lymphocytic leukemia,and immune thrombocytopenic purpura. Theresults were presented at the American Societyof Hematology 44th Annual Meeting inPhiladelphia, December 6 to 10, 2002.

More Than 70% of Patients With Refractory Immune Thrombocytopenic Purpura Responded to Rituximab

May 01, 2003

This special supplement to Oncology NewsInternational includes updated results ofstudies with anti-CD20 therapy and othertargeted therapies in the treatment oflymphomas, chronic lymphocytic leukemia,and immune thrombocytopenic purpura. Theresults were presented at the American Societyof Hematology 44th Annual Meeting inPhiladelphia, December 6 to 10, 2002.

Subcutaneous Alemtuzumab May Be as Effective as Intravenous But With Fewer Severe Complications

May 01, 2003

This special supplement to Oncology NewsInternational includes updated results ofstudies with anti-CD20 therapy and othertargeted therapies in the treatment oflymphomas, chronic lymphocytic leukemia,and immune thrombocytopenic purpura. Theresults were presented at the American Societyof Hematology 44th Annual Meeting inPhiladelphia, December 6 to 10, 2002.

Receptor Polymorphisms and Gene Clusters May Help Identify Individual Patients Most Likely to Benefit From Immunotherapy

May 01, 2003

This special supplement to Oncology NewsInternational includes updated results ofstudies with anti-CD20 therapy and othertargeted therapies in the treatment oflymphomas, chronic lymphocytic leukemia,and immune thrombocytopenic purpura. Theresults were presented at the American Societyof Hematology 44th Annual Meeting inPhiladelphia, December 6 to 10, 2002.City Hall in Philadelphia, Pennsylvania