Antidepressants a New Option for Managing Hot Flashes
May 01, 2003
CHICAGO-A low daily dose of venlafaxine (Effexor)-an antidepressant agent that affects reuptake of serotonin and norepinephrine-resulted in a 60% reduction in the "median hot flash score," a measure of the severity and frequency of hot flashes. The therapeutic dose range for treatment of depression is 75 to 225 mg/d; the 60% reduction in the hot flash score was achieved with only 75 mg/d. Charles Loprinzi, MD, director of medical oncology, Mayo Clinic, Rochester, Minnesota, reported the results at the Lynn Sage Breast Cancer Symposium.