Oncology NEWS International Vol 13 No 9

Temozolomide/RT Effective Against GBM

September 01, 2004

NEW ORLEANS-The chemotherapy drug temozolomide (Temodar) combined with radiation therapy more than doubled the 2-year survival rate in patients with glioblastoma multiforme (GBM), compared with radiation alone, according to data presented at the plenary session of the 40th Annual Meeting of the American Society of Clinical Oncology (abstract 2).

Older Breast Cancer Patients Can Forgo Axillary Clearance Without Compromising Survival: Results of IBCSG 10-93

September 01, 2004

NEW ORLEANS-The first results from a large international study presented at the 40th Annual Meeting of the American Society of Clinical Oncology (abstract 505) show that older node-negative breast cancer patients can avoid axillary clearance and have survival outcomes similar to those of women who undergo the invasive procedure. Stig Holmberg, MD, of Gothenberg, Sweden, principal investigator for the International Breast Cancer Study Group (IBCSG) Trial 10-93, said the study was performed to determine if sparing women the trauma and side effects associated with axillary clearance would improve their quality of life without compromising survival.

Bortezomib Superior to High-Dose Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma

September 01, 2004

NEW ORLEANS-Bortezomib (Velcade), a first-in-class proteasome inhibitor, provides significant benefit when used as a single agent in the treatment of relapsed or refractory multiple myeloma. This was the principal finding of an interim analysis of

Rituximab Improves Outcomes in Young Pts With Diffuse Large B-Cell NHL

September 01, 2004

NEW ORLEANS-For 25 years, oncologists made no progress in treating diffuse large B-cell non-Hodgkin’s lymphoma (DLBCL). Then, in 2000, the anti-CD20 antibody rituximab (Rituxan, MabThera in Europe) was shown to improve results in

TEGAFOX Could Replace FOLFOX in First-Line Metastatic Colorectal Cancer, French Trial Concludes

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

CAPIRI and CAPOX Comparable as Second- Line Tx for Metastatic Colorectal Cancer

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

XELIRI Shows Promise as First-Line Treatment for Advanced Colorectal Cancers, US and Spanish Trials Report

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

Promising Response to TK Inhibitor Erlotinib in Second-Line Metastatic Colorectal Cancer

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

Capecitabine Impact on QOL Significant in Patients With Metastatic Breast Cancer

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

Thymidine Phosphorylase Expression ‘Useful’ as Predictive Marker of Response to Capecitabine

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

COX-2: Can Celecoxib Help Capecitabine ‘XCEL’ in Metastatic Colorectal Cancer?

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

GEMOX Shows Significant Clinical Benefit vs Gemcitabine in Advanced Pancreatic Cancer

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

Capecitabine Replaces 5-FU in Asian Metastatic Gastric Cancer Investigations

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

MOSAIC Data Support FOLFOX- 4 Use in High-Risk Stage II Colon Cancer

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

UFT Provides ‘Equivalent’ Survival and Quality of Life to 5-FU in Stage II/III Colorectal Cancer

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

In Esophageal Cancer, Promising Trimodality Approach Increases 5-FU Exposure

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

Cetuximab Is a Good Option When Standard Treatment Fails, Large Trial Reports

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

Capecitabine Should Replace 5-FU in Adjuvant Treatment of Dukes’ C Colon Cancer, Investigator Avers

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

Capecitabine/RT Can Replace Cisplatin in Elderly Bladder Cancer Patients

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

Nonanthracycline Neoadjuvant Regimen Appears Effective and Safe in Stage II/III Breast Cancer

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

Capecitabine Promises Convenience, Efficacy in LARC, Five Studies Show

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

IFL Usefulness Does Not Extend to Adjuvant Treatment of Stage III Colon Cancer

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

Cetuximab in First-line Treatment With FOLFOX or FOLFIRI Yields Low Rate of Progressive Disease

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

X-ACT Subanalysis Finds First-Line Adjuvant Capecitabine Cost-Effective vs 5-FU/LV for Dukes’ C Colon Cancer

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

Small But Significant Survival Advantage for Dukes’ B Patients on FUFA Regimen

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

Bevacizumab Benefits Patients Who Are Not Candidates for First-Line Irinotecan

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

Bevacizumab Assessed in Three Safety Studies of Bleeding, Wound Healing Complications in CRC

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

Oxaliplatin Added to First-Line Therapy Increases Response in Metastatic CRC

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

In Colorectal Cancer, Reduced-Dose IFL Is Active, Less Toxic Than FOLFOX

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

Treating More Women, Elderly Could Improve Colon Cancer Survival

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.

Adding Bevacizumab to 5-FU/LV Reduced Risk of Death by 25% in Metastatic Colorectal Cancer

September 01, 2004

The 30 reports in this special supplement to Oncology News International represent highlights of ongoing major clinical trials and new research presented at ASCO 2004 regarding state-of-the-art chemotherapeutic management of gastrointestinal and other cancers. Important developments in capecitabine as adjuvant therapy, novel targeted agents, and new combinations are discussed.