Oncology NEWS International Vol 16 No 1

Congress Plans to Keep NCI Operating at FY2006 Budget

January 01, 2007

Congress adjourned and retreated from the nation's capital in early December without passing 9 of the 11 fiscal year (FY) 2007 appropriations bills, including that of the Department of Health and Human Services.

With Decrease in HRT Use, Breast Ca Incidence Rates Fall

January 01, 2007

Reversing a decades-old trend, the incidence of invasive breast cancer dropped dramatically in 2003, relative to 2002, possibly a result of postmenopausal women discontinuing hormone replacement therapy (HRT) due to breast cancer concerns

MK-0457 'Glides Past' Bcr-Abl T315i Mutation

January 01, 2007

MK-0457, an investigational small molecule inhibitor of Aurora, JAK-2, and Bcr-Abl kinases, has demonstrated clinical activity in patients with Bcr-Abl T315i mutant chronic myelogenous leukemia (CML)

Lilly 2006 Oncology on Canvas Winners 'Embrace Life'

January 01, 2007

A striking black-and-white photograph (see Figure) of nursing student Katherine Wilson, a nonsmoker who lived 5 years with small-cell lung cancer before dying in 2005 at age 28, won the Best of the United States first prize in the 2006 Lilly Oncology on Canvas: Expressions of a Cancer Journey International Art Competition and Exhibition. The US competition finale was held at the Metropolitan Pavilion, New York, with Lilly President and COO John C. Lechleiter, PhD, presenting the top three US finalists with their awards.

Medicare Fee Poor Proxy in Economic Analyses of Mammography

January 01, 2007

A random sampling of 2.3% of the imaging centers that meet Mammography Quality Standards Act (MQSA) certification showed that the national median cash price for a screening mammogram is more than double the price that is reimbursed by Medicare.

IMRT of the Breast Markedly Reduces Moist Desquamation

January 01, 2007

In a randomized trial, breast cancer patients who underwent postoperative intensity modulated radiation therapy (IMRT) had a markedly reduced incidence of moist desquamation and overall skin toxicity, compared with those receiving standard radiation therapy.

Erbitux Ups PFS in Metastatic Colon Cancer

January 01, 2007

ImClone Systems and Bristol-Myers Squibb have announced that a phase III study of cetuximab (Erbitux) plus FOLFIRI (an irinotecan-based chemotherapy regimen) met the primary endpoint of increasing median duration of progression-free survival (PFS) over FOLFIRI alone in patients with previously untreated metastatic colorectal cancer.

ASCO Names Top 6 Ca Advances

January 01, 2007

In its second annual "Clinical Cancer Advances" report, the American Society of Clinical Oncology (ASCO) selected six notable developments in clinical cancer research as most important in 2006.

Familial Pancreatic Ca Gene Mutation Discovery

January 01, 2007

Mutation of palladin, a cytoskeletal gene that controls cell shape and motility, and overexpression of palladin protein are implicated in both familial and sporadic forms of pancreatic cancer, respectively, and explain the typical nuclear disarray seen histologically in patients with the disease

Expression Pattern of Five Genes Predicts NSCLC Outcome

January 01, 2007

Taiwan-based researchers have defined and validated a set of five genes whose degree of expression in non-small-cell lung cancer (NSCLC) patients closely predicts their relapse-free and overall survival.

Digital Mammography Best for Young Women With Dense Breasts

January 01, 2007

New subgroup analyses from the Digital Mammographic Imaging Screening Trial (DMIST) Investigators Group confirm previous results that digital screening mammography is significantly more accurate than film screening mammography in young women with dense breasts but not in women overall.

Nilotinib Shows Significant Clinical Activity in CP-CML

January 01, 2007

The investigational agent nilotinib (Tasigna) has shown significant clinical activity and an acceptable safety and tolerability profile in the treatment of imatinib (Gleevec) resistant or intolerant, chronic phase chronic myelogenous leukemia (CP-CML)

BCIRG 006 Update Questions Role of Anthracyclines

January 01, 2007

A second interim efficacy analysis of the phase III Breast Cancer International Research Group (BCIRG) 006 study confirmed the benefits reported previously for docetaxel (Taxotere)-plus-trastuzumab (Herceptin) regimens in early HER2-positive breast cancer, and further showed a higher rate of toxicity for anthracycline-based regimens.

FDA Says No to Genasense for CLL

January 01, 2007

Genta Incorporated announced that it has received notice that its New Drug Application for the use of Genasense (oblimersen) plus chemotherapy in patients with relapsed/refractory chronic lymphocytic leukemia (CLL)

Annual CT Screening May Overdiagnose Lung Ca in Women

January 01, 2007

A retrospective review of 61 lung cancers identified during annual CT screening of high-risk individuals found that an exceptionally high rate of tumors may have been "overdiagnosed," particularly in women.

Teleoncology Improves Access to Care for Rural Patients: As Utilization Goes Up, Costs Go Down

January 01, 2007

In rural areas, access to quality cancer care is especially challenging. The cumbersome process of traveling long distances for care is exacerbated by the symptoms associated with disease, leaving many rural cancer patients undertreated. However, a relatively new telecommunication technology offers one way to overcome the geographic barriers faced by rural Americans. Cancer Care & Economics (CC&E) spoke with Ryan J. Spaulding, PhD, director of the Center for Telemedicine and Telehealth at Kansas University Medical Center (KUMC), Kansas City, about how telemedicine helps serve patients in rural Kansas.