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Brain Tumors

Current and Emerging Treatments for Brain Metastases

Jenny Lin, BA, Rahul Jandial, MD, PhD, Amanda Nesbit, BS, et al; ONCOLOGY Vol. 29; No. 4
Conventional methods for treating brain metastasis, such as surgery, WBRT, and SRS, each compete with and complement one another. A plethora of recent studies have helped define and expand the utility of these tools.

Brain Tumors

Meningiomas are the most common primary brain tumor and comprise nearly one-third of all newly diagnosed primary brain tumors.

Childhood cancer patients treated with brain irradiation may be at a higher risk for developing into obese adults, according to a new study.

Conventional methods for treating brain metastasis, such as surgery, WBRT, and SRS, each compete with and complement one another. A plethora of recent studies have helped define and expand the utility of these tools.

Some targeted systemic therapies have demonstrated evidence of activity in the brain—specifically in melanoma, lung cancers, and breast cancers—and these agents warrant further study in clinical trials.

It is time to put aside the pessimism of the past when it comes to brain metastases and embrace the wide array of clinical investigational opportunities arising in this field.

There is no evidence that PCV is more effective than TMZ for the treatment of glioblastoma. However, there is unequivocal evidence that PCV is more toxic than TMZ.

In most cases, PCV chemotherapy will provide an edge in outcomes over TMZ for glioma patients, primarily because of the former regimen’s use of multiple drugs and their complementary interactions.

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