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Breast Cancer

70-Gene Signature Could Help Early-Stage Breast Cancer Patients Avoid Chemotherapy

Using a 70-gene signature test could identify many women with early-stage breast cancer considered to be at high clinical risk who do not actually need chemotherapy. Image © anyaivanova / Shutterstock.com.

Breast Cancer

In patients with HER2-positive breast cancer undergoing trastuzumab therapy, the use of an ACE inhibitor or beta-blocker could protect against cardiac toxicity.

Patients with ER-positive, HER2-negative advanced breast cancer had significant delays in progression when palbociclib was added to letrozole treatment, according to the double-blind PALOMA-2 study.

Polymorphisms in the FCGR3A gene are correlated with degree of benefit from trastuzumab in women with ERBB2/HER2-positive breast cancer, according to a new analysis.

Serum levels of a vitamin D biomarker measured at the time of breast cancer diagnosis were independently associated with breast cancer prognosis, especially among premenopausal women.

The antibody-drug conjugate trastuzumab emtansine (T-DM1) showed non-inferior—but not superior—efficacy to trastuzumab plus a taxane in women with advanced HER2-positive breast cancer.

Tailored dose-dense chemotherapy in high-risk early breast cancer patients did not show a significant improvement in recurrence-free survival compared with standard adjuvant chemotherapy.

Stratifying breast cancer patients by chemotherapy and genetic susceptibility, researchers were able to identify patients at high risk of venous thromboembolism.


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