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Breast Cancer

70-Gene Signature Could Help Early-Stage Breast Cancer Patients Avoid Chemotherapy

Using a 70-gene signature test could identify many women with early-stage breast cancer considered to be at high clinical risk who do not actually need chemotherapy. Image © anyaivanova / Shutterstock.com.

Breast Cancer

In July 2003, an asymptomatic 40-year-old man presented to his primary care physician for routine care and was found to have a palpable right axillary lymph node.

Brain metastases from primary breast cancer tumors often acquire clinically actionable genetic alterations, according to a small study. About one fifth of ERBB2/HER2-negative cases switched to HER2-positivity in the brain metastases.

The use of mammography, but not colonoscopy, has increased in the post–Affordable Care Act years, which eliminated out-of-pocket expenditures for these recommended services, according to the results of a new study.

Breast cancer screening was not associated with any reduction in the incidence of advanced cancer, and overdiagnosis of invasive tumors and ductal carcinoma in situ is a common problem, according to a new study conducted in Denmark.

Among cancer patients with bone metastases, administration of zoledronic acid every 12 weeks did not increase the risk of skeletal events over 2 years compared with the standard dosing of every 4 weeks.

The use of acellular dermal matrices in implant-based breast reconstruction after mastectomy was associated with an increased rate of adverse events compared with a two-stage procedure.

The FDA has approved a new device that allows for the expansion of soft tissue in two-stage breast reconstruction surgery conducted after mastectomy.

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