ABSTRACT: Breast cancer treatments today are likely to cause less physical deformity from surgery than a half-century ago, but are more complex and extend over a longer period of time. Women today are often well informed about the details of their cancer diagnosis and prognosis, and are increasingly involved in shared decision-making regarding treatment. Although serious depression is not seen in the majority of breast cancer patients and survivors, many will experience treatment-related distress, fear of recurrence, changes in body image and sexuality, as well as physical toxicities that result from adjuvant therapy. This paper discusses the importance of identifying the psychological and social concerns of breast cancer patients in the medical setting, and assisting them in obtaining appropriate psychosocial services.
In delivering care for breast cancer patients today, it is expected that the health-care team will carefully evaluate the tumor pathology, biomarkers, extent of disease, and other medical aspects of the woman’s condition, to facilitate specific recommendations for oncologic management. This has been increasingly true in the past decade, as the understanding of the molecular pathology of breast cancer has increased and treatments have become more tailored.
In the past 50 years, breast cancer has been transformed from a disease in which all women were treated with a radical and disfiguring surgical procedure that amputated the breast, removed pectoral muscles, and included an extensive axillary dissection. Now, for the majority of women, it is usually managed with only minimal removal of breast tissue and sampling of a few axillary nodes. During this same period of time, women with breast cancer have become increasingly involved in treatment decision-making, and have made it clear that they have need for attention to the psychological and social aspects of their care, in addition to the targeted treatment of their tumors.
This was not always the case, and we must be grateful to the pioneering work of Dr. Martin Abeloff and his colleagues, who more than 3 decades ago recognized the intimate relationship between the psychological and social impact of cancer and its treatments on patients’ lives (see Table 1). In his passing, many tributes noted Marty’s important contributions to oncology, as a pioneer in the treatment of breast cancer and as the leader of a major cancer center. The one that caught my attention noted remarks he made at a Johns Hopkins event in the year before his death, where he is reported to have said, “Therapies have been lengthy, toxic, and disfiguring, adding to the amount of suffering that a patient and family endures. You simply can’t treat cancer without paying attention to the psychological and social aspects of the disease.”
To this end, I review what we have learned about the psychological and social aspects of breast cancer during Dr. Abeloff’s distinguished career, and how leaders such as he have promoted the integration of psychosocial services into the standard care of oncology patients through their words and their actions.
Psychological and Social Impact of Breast Cancer: Historical Reflections
For almost a century, the Halsted radical mastectomy was the standard surgical treatment for breast cancer. Women receiving this treatment suffered terrible cosmetic deformity, with loss of arm function through resection of the pectoral muscles, high risk for lymphedema as the result of extensive axillary nodal dissection, and significant pain and tightness across the chest wall. Attempts to restore body image with external prostheses were variably effective, and reconstructive surgery with implants did not become widely available until the last 2 decades of the 20th century. Reconstruction was often delayed for several years after initial treatment, requiring a second surgical procedure. Immediate reconstruction and autologous tissue flaps, widely used today, did not become widespread until the turn of the 21st century.
Not until the 1990 National Institutes of Health (NIH) Consensus Conference on early-stage breast cancer was a concerted effort made to encourage breast conserving surgery, based on the mounting evidence of its efficacy in randomized trials conducted in the 1980s. Further refinements in surgical staging, including the sentinel lymph node biopsy, have now begun to limit the extent of axillary surgery for women with small tumors and low metastatic potential. The trauma of breast cancer surgery has diminished substantially in the past 2 decades, but women are still left with many physical and psychological problems as a result of complex multimodal treatments, including chemotherapy and adjuvant endocrine therapies.[3-5]
The earliest research on the psychological impact of breast cancer focused on its attack on femininity, with amputation of the breast, and subsequent threat to sexual attractiveness. In addition to these concerns, the life-threatening nature of cancer itself contributed to psychological distress. The involvement of mental health experts in the problems of persons with health conditions began to accelerate during the 1960s and 1970s, just as the national focus on cancer treatment and the war on cancer was taking shape. In her classic 1980 paper on the psychosocial correlates of breast cancer and its treatments, Meyerowitz pointed out that during this time, most patients were not told their diagnosis, for fear of the emotional response it would evoke. Much of the literature of the time also postulated that personality traits could be causal in the development of cancer, and that postoperative behavior might reflect pre-illness characteristics, rather than be the result of treatment.
The stress of breast cancer was described as arousing depression, anxiety, and anger. In some of the first systematic and comparative studies, mastectomy patients were found to be more distressed than women with benign lumps, and often this distress persisted for more than a year following surgery, but over time seemed to resolve. These findings in the late 1970s were gradually disseminated to physicians and patients, and resulted in the beginnings of psychosocial support groups in the early 1980s.
Meyerowitz also noted the identification of changes in life patterns that resulted from the diagnosis and surgical treatment of breast cancer, including insomnia, recurrent nightmares, loss of appetite, difficulty returning to usual household activities and work, and inability to concentrate. Although these may have been manifestations of depression, they were only considered abnormal if they persisted beyond the period of physical recovery from surgery (ie, several months). The physical disruption of the radical mastectomy was substantial, making it difficult to sleep, have sexual intimacy, and adapt to clothing and body image problems. Return to usual physical and social activities was also reportedly diminished in many women.
Finally, Meyerowitz described common fears and concerns that women reported, and these include fear of recurrence—tumors were much larger and 50% of women could expect to have a recurrence in spite of radical surgery—as well as the mutilation and loss of feminity as a result of mastectomy. For many women, every ache and pain would trigger fear and anxiety about potential recurrence. Given the limited amount of information exchanged between doctors and patients at this time regarding the natural history of breast cancer and its prognosis, as well as the lack of adjuvant therapies to prevent a recurrence, it is not surprising that these fears were commonplace. Today, with extensive patient education, in the doctor’s office as well as from many patient-focused resources (Internet websites, breast cancer organizations, professional organizations), patients may still have legitimate fears, but they are much better armed with facts.
Another important aspect of this historical time in breast cancer treatment was the stigma associated with a cancer diagnosis, and the lack of support for patients beyond their families as they went through cancer diagnosis and treatment. In today’s environment, a woman who has an image-guided breast biopsy and receives a cancer diagnosis is immediately approached by other women—from her work, church, or other social network—who are breast cancer patients/survivors, and who are immediately ready to help her get through the early diagnosis and staging of the cancer, and provide support and encouragement.
Management of Breast Cancer in the Abeloff Era: Psychological and Social Aspects
The first large trials of adjuvant chemotherapy were reported in high-profile medical journals in the 1970s and 1980s,[7-10] leading to the rapid expansion of clinical trials of this treatment across all stages of breast cancer throughout the world, with testing of new drugs and their combinations, including the addition of endocrine therapies to the treatment strategy. Gradually, treatments became more intensive[11,12] and there was increasing interest in the measurement of quality-of-life outcomes in these clinical trials.[13-16] This culminated in the widespread use of high-dose chemotherapy with autologous bone marrow or stem cell transplantation, which was ultimately found to be ineffective as well as highly toxic.
Since the 2000 NIH consensus conference on adjuvant therapy of breast cancer, adjuvant therapy has been recommended for all women with invasive breast tumors greater than 1 cm, including chemotherapy in all and endocrine therapy if hormone receptor–positive. High-dose therapy has been largely abandoned, and treatments have been further modified through better understanding of the molecular risk profiles for primary breast cancer, including HER2 overexpression.
Thus, today there is even more information to discuss with newly diagnosed breast cancer patients than before. The shared decision-making process may be stressful, and use of decision aids, as discussed in the 2000 consensus conference,[19,20] has become more common. How this complex information is communicated, and how the physician assesses the woman’s psychological status and desire for detailed information vs more general concepts, often sets the stage how the woman will adapt to her diagnosis and need for treatment.
The major psychological and social stressors under these circumstances are related to the woman’s understanding of her disease, its prognosis, the complexity of treatment, and all too often, her access to care and/or choice of providers. Even the most psychologically strong individual will be overwhelmed by the number of medical visits, procedures, and waiting times during the initial diagnostic process. This is then followed by the need to organize care with multiple providers (surgeon, radiation oncologist, medical oncologist, plastic surgeon) and often second opinions to assist in decision-making.
The complexity of primary treatment, information overload (from health-care providers, well-meaning acquaintances, books, and the Internet), the move toward shared decision-making, and the vulnerability that a cancer diagnosis engenders, all threaten the emotional well-being of the woman. Facing many months of treatment leads to disruption in social activities (childcare, work, caregiving) and decreases the ability to plan and multitask. This is exacerbated by the physical toll that primary treatment often extracts.
1. Hewitt ME, Herdman R, Holland JC: Meeting psychosocial needs of women with breast cancer. Washington, DC; National Academies Press; 2004.
2. National Institutes of Health Consensus Statement: Early stage breast cancer. Consens Statement 8(6):1-19, 1990.
3. Ganz PA, Rowland JH, Desmond K, et al: Life after breast cancer: understanding women’s health-related quality of life and sexual functioning. J Clin Oncol 16:501-514, 1998.
4. Ganz PA, Rowland JH, Meyerowitz BE, et al: Impact of different adjuvant therapy strategies on quality of life in breast cancer survivors. Recent Results Cancer Res 152:396-411, 1998.
5. Ganz PA, Kwan L, Stanton AL, et al: Quality of life at the end of primary treatment of breast cancer: First results from the moving beyond cancer randomized trial. J Natl Cancer Inst 96:376-387, 2004.
6. Meyerowitz BE: Psychosocial correlates of breast cancer and its treatments. Psychol Bull 87:108-131, 1980.
7. Fisher B, Carbone P, Economou SG, et al: 1-Phenylalanine mustard (L-PAM) in the management of primary breast cancer. A report of early findings. N Engl J Med 292:117-122, 1975.
8. Fisher B, Redmond C, Brown A, et al: Treatment of primary breast cancer with chemotherapy and tamoxifen. N Engl J Med 305:1-6, 1981.
9. Wolmark N, Fisher B: Adjuvant chemotherapy in stage-II breast cancer: An overview of the NSABP clinical trials. Breast Cancer Res Treat 3(suppl):S19-S26, 1983.
10. Bonadonna G, Valagussa P: Dose-response effect of adjuvant chemotherapy in breast cancer. N Engl J Med 304:10-15, 1981.
11. Abeloff MD, Beveridge RA, Donehower RC, et al: Sixteen-week dose-intense chemotherapy in the adjuvant treatment of breast cancer. J Natl Cancer Inst 82:570-574, 1990.
12. Fetting JH, Gray R, Fairclough DL, et al: Sixteen-week multidrug regimen versus cyclophosphamide, doxorubicin, and fluorouracil as adjuvant therapy for node-positive, receptor- negative breast cancer: An Intergroup study. J Clin Oncol 16:2382-2391, 1998.
13. Fairclough DL, Fetting JH, Cella D, et al: Quality of life and quality adjusted survival for breast cancer patients receiving adjuvant therapy. Eastern Cooperative Oncology Group (ECOG). Qual Life Res 8:723-731, 1999.
14. Fetting JH: Psychosocial and other supportive aspects of breast cancer care. Curr Opin Oncol 1:333-336, 1989.
15. Fetting JH: Psychosocial aspects of breast cancer. Curr Opin Oncol 3:1014-1018, 1991.
16. Fetting JH: Evaluating quality and quantity of life in breast cancer adjuvant trials. J Clin Oncol 6:1795-1797, 1988.
17. Welch HG, Mogielnicki J: Presumed benefit: Lessons from the American experience with marrow transplantation for breast cancer. BMJ 324:1088-1092, 2002.
18. National Institutes of Health Consensus Development Conference Statement: Adjuvant therapy for breast cancer, November 1-3, 2000. J Natl Cancer Inst 93:979-989, 2001.
19. Langer AS: Side effects, quality-of-life issues, and trade-offs: The patient perspective. J Natl Cancer Inst Monogr 30:125-129, 2001.
20. Levine M, Whelan T: Decision-making process—communicating risk/benefits: Is there an ideal technique? J Natl Cancer Inst Monogr 30:143-145, 2001.
21. Ganz PA: Treatment options for breast cancer—beyond survival. N Engl J Med 326:1147-1149, 1992.
22. Ganz PA: Quality of life and the patient with cancer. Individual and policy implications. Cancer 74(4 suppl):1445-1452, 1994.
23. Ganz PA, Coscarelli A, Fred C, et al: Breast cancer survivors: Psychosocial concerns and quality of life. Breast Cancer Res Treat 38:183-199, 1996.
24. Schag CA, Ganz PA, Polinsky ML, et al: Characteristics of women at risk for psychosocial distress in the year after breast cancer. J Clin Oncol 11:783-793, 1993.
25. Maunsell E, Brisson J, Deschenes L: Psychological distress after initial treatment of breast cancer. Assessment of potential risk factors. Cancer 70:120-125, 1992.
26. Frost MH, Suman VJ, Rummans TA, et al: Physical, psychological and social well-being of women with breast cancer: The influence of disease phase. Psychooncology 9:221-231, 2000.
27. Ganz PA, Desmond KA, Leedham B, et al: Quality of life in long-term, disease-free survivors of breast cancer: A follow-up study. J Natl Cancer Inst 94:39-49, 2002.
28. Dorval M, Maunsell E, Deschenes L, et al: Long-term quality of life after breast cancer: Comparison of 8-year survivors with population controls. J Clin Oncol 16:487-494, 1998.
29. Bull AA, Meyerowitz BE, Hart S, et al: Quality of life in women with recurrent breast cancer. Breast Cancer Res Treat 54:47-57, 1999.
30. Maunsell E, Brisson J, Deschenes L: Social support and survival among women with breast cancer. Cancer 76:631-637, 1995.
31. Ganz PA, Hirji K, Sim MS, et al: Predicting psychosocial risk in patients with breast cancer. Med Care 31:419-431, 1993.
32. Shimozuma K, Ganz PA, Petersen L, et al: Quality of life in the first year after breast cancer surgery: Rehabilitation needs and patterns of recovery. Breast Cancer Res Treat 56:45-57, 1999.
33. Schover LR: Sexuality and body image in younger women with breast cancer. J Natl Cancer Inst Monogr 16:177-182, 1994.
34. Ganz PA, Lee JJ, Sim MS, et al: Exploring the influence of multiple variables on the relationship of age to quality of life in women with breast cancer. J Clin Epidemiol 45:473-485, 1992.
35. Maunsell E, Brisson J, Deschenes L: Psychological distress after initial treatment for breast cancer: A comparison of partial and total mastectomy. J Clin Epidemiol 42:765-771, 1989.
36. Ganz PA, Schag AC, Lee JJ, et al: Breast conservation versus mastectomy. Is there a difference in psychological adjustment or quality of life in the year after surgery? Cancer 69:1729-1738, 1992.
37. Rakovitch E, Franssen E, Kim J, et al: A comparison of risk perception and psychological morbidity in women with ductal carcinoma in situ and early invasive breast cancer. Breast Cancer Res Treat 77:285-293, 2003.
38. van Gestel YR, Voogd AC, Vingerhoets AJ, et al: A comparison of quality of life, disease impact and risk perception in women with invasive breast cancer and ductal carcinoma in situ. Eur J Cancer 43:549-556, 2007.
39. Lansky SB, List MA, Herrmann CA, et al: Absence of major depressive disorder in female cancer patients. J Clin Oncol 3:1553-1560, 1985.
40. Narrow WE, Rae DS, Robins LN, et al: Revised prevalence estimates of mental disorders in the United States: Using a clinical significance criterion to reconcile 2 surveys’ estimates. Arch Gen Psychiatry 59:115-123, 2002.
41. Ganz PA, Hirji K, Sim MS, et al: Predicting psychosocial risk in patients with breast cancer. Med Care 31:419-431, 1993.
42. Ganz PA, Hirji K, Sim MS, et al: Predicting psychosocial risk in patients with breast cancer. Med Care 31:419-431, 1993.
43. Greenfield S, Blanco DM, Elashoff RM, et al: Patterns of care related to age of breast cancer patients. JAMA 257:2766-2770, 1987.
44. Lash TL, Silliman RA: Patient characteristics and treatments associated with a decline in upper-body function following breast cancer therapy. J Clin Epidemiol 53:615-622, 2000.
45. Bloom JR: Social support, accommodation to stress and adjustment to breast cancer. Soc Sci Med 16:1329-1338, 1982.
46. Bloom JR, Spiegel D: The relationship of two dimensions of social support to the psychological well-being and social functioning of women with advanced breast cancer. Soc Sci Med 19:831-837, 1984.
47. Koopman C, Hermanson K, Diamond S, et al: Social support, life stress, pain and emotional adjustment to advanced breast cancer. Psychooncology 7:101-111, 1998.
48. Stanton AL, Ganz PA, Kwan L, et al: Outcomes from the Moving Beyond Cancer psychoeducational, randomized, controlled trial with breast cancer patients. J Clin Oncol 23:6009-6018, 2005.
49. Committee on Pyschosocial Services to Cancer Patients/Families in a Community Setting: Cancer Care for the Whole Patient: Meeting Psychosocial Health Needs. Washington, DC; National Academies Press; 2007.