Perioperative Pembrolizumab Enhances Survival in Locally Advanced HNSCC
Event-free survival events were observed in 37.5% of patients with resectable locally advanced HNSCC who took pembrolizumab vs 45.3% in those who did not.
79 Case Series of Pathologic Upgrade After Reconstructive Breast Surgery
Linvoseltamab Receives EU Approval for Relapsed/Refractory Multiple Myeloma
The EU approval was based on results from the phase 1/2 LINKER-MM1 trial assessing the efficacy of linvoseltamab in relapsed/refractory multiple myeloma.
Societal Changes, COVID-19 Among Causes of Oncologist Burnout
“Although telehealth is a great thing when used properly, telehealth also puts a barrier between the doctor and the patient,” said Eric P. Winer, MD.
Bone Marrow Test Reveals Improved Survival in NPM1 and FLT3-Mutated AML
This study conducted within the phase 3 AML17 and AML19 trials revealed an OS rate of 69% in patients monitored for MRD and 58% in those not monitored.
FDA Approves Multi-Dose Thiotepa Vial for Breast and Ovarian Cancers
The regulatory decision may offer more scheduling flexibility for patients who receive thiotepa for breast or ovarian cancer.
Anlotinib Combo Improves PFS/OS in Extensive-Stage Small Cell Lung Cancer
Data may support anlotinib/benmelstobart plus chemotherapy as a preferable frontline treatment option in extensive-stage small cell lung cancer.
The CHMP Recommends Acalabrutinib Combos For Approval in Untreated CLL
Results from the phase 3 AMPLIFY trial showed that acalabrutinib plus venetoclax, with or without obinutuzumab, prolonged PFS vs chemoimmunotherapy in CLL.
Cretostimogene Grenadenorepvec Displays Efficacy in BCG-Unresponsive NMIBC
Complete response rates were observed consistently across patient subgroups in those with high-risk BCG-unresponsive non-muscle invasive bladder cancer.
81 Assessing Recurrence Likelihood in Hormone Receptor–Positive/HER2-Negative Breast Cancer Patients Directly From MRI Using Imaging AI
Investigators Discontinue Trial Assessing Capivasertib in Metastatic CRPC
A recommendation from an independent data monitoring committee prompted the discontinuation of the phase 3 CAPItello-280 trial.
PET/CT Lymph Node Staging Doesn't Predict Worse Outcomes After Bladder Cancer Surgery
18F-FDG PET/CT staging of lymph node metastases in patients with bladder cancer undergoing radical cystectomy did not correlate with worse survival outcomes.
Surgical Overtreatment Has Declined in Grade Group 1 Prostate Cancer
Data show that patients who undergo grade group 1 prostatectomies may experience an increased likelihood of higher risk features.
Outpatient Robotic Partial Nephrectomy Is Safe/Feasible for Renal Tumors
A prospective trial established that 97% of patients were successfully discharged on the same day as receiving robotic partial nephrectomy.
Pelvic Radiation Confers More Complications After Bladder Cancer Surgery
Findings may establish a framework for assisting patient counselling and optimizing therapy selection for those undergoing radical cystectomy.
Hypofractionated RT Shows Portal Vein Tumor Thrombosis Control, OS in HCC
Ten-fraction image-guided hypofractionated radiation therapy could be a feasible treatment option for portal vein tumor thrombosis in patients with HCC.
Organ Preservation Noted With Neoadjuvant Dostarlimab in dMMR Tumors
A phase 2 study found a complete clinical response of 82% with neoadjuvant dostarlimab in dMMR solid tumors.
Zanidatamab Recommended for Conditional Marketing Approval in Advanced HER2+ BTC
The recommendation from the CHMP is based on results from the phase 2b HERIZON-BTC-01 trial of zanidatamab in advanced HER2+ biliary tract cancer.
Low-Dose CT Screening for Lung Cancer Shows Large-Scale Efficacy
Study data show a small number of individuals with a lung cancer diagnosis within 12 months of a negative baseline screening result.
Nurulimab/Prolgolimab Yield Superior Efficacy in Advanced Melanoma
The combination of nurulimab plus prolgolimab enhanced PFS, ORR, and DCR compared with prolgolimab monotherapy in unresectable or metastatic melanoma.
82 Efficacy, Safety, and Biomarker Analysis of ICARUS-BREAST01: A Phase 2 Study of Patritumab Deruxtecan (HER3-DXd) in Patients With HR+/HER2– Advanced Breast Cancer
Same-Day G-CSF After Chemo Appears Safe, Efficacious in Breast Cancer
No grade 3/4 treatment-related adverse effects were observed in patients receiving efbemalenograstim alfa for breast cancer in the Guard-02 trial.
Frailty Assessments Indicate Severe AE Probability in Prostate Cancer
BMI, serum albumin, and G8 screening tool scores were all factors correlated with the likelihood of experiencing a grade 3 or higher AE.
Health Care Professional Research Highlights Barriers to Clinical Trial Diversity
Radical Prostatectomy Linked to Lower GU Toxicity in Localized Prostate Cancer
Toxicity complications were assessed between single- and multiple-treatment modalities for patients with localized prostate cancer.
Mortality, Adverse Outcome Odds Higher in Multiple Myeloma PEM Population
Findings indicate a need to address protein-energy malnutrition in the treatment of those who have multiple myeloma with acute congestive heart failure.
NOTCH1 Mutational Status May Predict ICI Outcomes in Esophageal Cancer
According to comparative single-cell transcriptome analyses, NOTCH1 deficiency facilitated a more immunologically active microenvironment in ESCC tumors.
Elucidating Non-Invasive Radiosurgery Advancements in CNS Tumors
A dedicated, well-trained, and expert staff at the Ivy Brain Tumor Center enables the facility to be at the forefront of cutting-edge radiosurgery treatment.
TPS 83 ELAINE 3: Open-Label, Randomized, Multicenter, Phase 3 Study of the Efficacy and Safety of Lasofoxifene Plus Abemaciclib for Treating Locally Advanced or Metastatic, ER+/HER2–, Breast Cancer With an ESR1 Mutation
Outlining Strategies for Effectively Implementing Integrative Oncology Care
Findings from clinical trials conducted in recent years demonstrate the benefit of integrative oncology for patients undergoing treatment for cancer.