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Why BRAF-Mutated Colorectal Cancers Don't Respond to BRAF Inhibitors
January 30, 2012
Hypermethylation of TFAP2E Gene in Colorectal Cancer Associated With Unresponsiveness to the Chemotherapy Fluorouracil
January 27, 2012
Ginger Root Extract’s Potential in Colorectal Cancer Prevention
ONCOLOGY,  October 25, 2011
Could Aspirin Be a Viable Adjuvant Treatment for Cancer?
ONCOLOGY,  October 17, 2011
EMCC: Oral Anti-Angiogenesis Treatment Plus Chemotherapy Is Not More Efficacious Than Bevacizumab Plus Chemotherapy in Metastatic Colorectal Cancer
ONCOLOGY,  September 30, 2011


 
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Colorectal Cancer
 
REVIEW ARTICLES

Have the Changes in Treatment of Rectal Cancer Made a Significant Difference to Our Patients?
Al B. Benson, III, MD, FACP1, Jose G. Guillem, MD, MPH2, Bruce D. Minsky, MD3 , December 31, 2011

Treatment for patients with locally advanced, resectable rectal cancer has clearly evolved, with significant refinements in preoperative assessment, surgical technique, and use of preoperative CMT.
• Transanal Excision of Rectal Cancer: A Work in Progress
• Chronicling Strides in Understanding and Managing Rectal Cancer

Metastatic Colorectal Cancer: Management Challenges and Opportunities
Gail M. Wilkes, MS, APRN-BC, AOCN1 , July 11, 2011

CME
Advances in the multidisciplinary management of metastatic colorectal cancer have improved survival considerably, and nurses are key to optimal patient care.
• The Evolving Care of Metastatic Colorectal Cancer

Targeting the Insulin Growth Factor Pathway in Gastrointestinal Cancers
Talia Golan, MD1, Milind Javle, MD2 , May 17, 2011

Recently, randomized phase II trials combining IGF-1R with epidermal grown factor receptor (EGFR) inhibition in colorectal cancer have been completed. Preclinical studies have indicated that several biomarkers may have potential predictive value.
• Targeting IGF-1R: at a Crossroad
• The IGF-1R Pathway as a Therapeutic Target

How Long Have I Had My Cancer, Doctor?
Michael V. Patrone1, Jessica L. Hubbs, MS2,
Janet E. Bailey, BA3, Lawrence B. Marks, MD3 , January 24, 2011

To estimate the “age” of cancers, we reviewed data on the “time to local/regional recurrence” (LRF) following initial surgical resection for three common cancers, then applied a modified version of Collins’ law.
• Influences on the Natural History of Cancers
• Kinetics of Cancer: Implications from Prevention to Prognostication
• Cancer Age: Can We Reliably Estimate and Apply This Knowledge?

Intensity-Modulated Radiation Therapy for Anal Cancer: Toxicity versus Outcomes
Timothy M. Zagar, MD1, Christopher G. Willett, MD2, Brian G. Czito, MD3 , August 24, 2010

This article reviews the relevant literature leading up to the modern treatment of anal canal cancer, and discusses IMRT-related toxicity and disease-related outcomes in the context of outcomes of conventionally treated anal cancer.
• An Obvious yet Complicated Transition
 
JOURNAL SCAN
Molecular Cancer | Comments | Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells
www.molecular-cancer.com - 1/4/12
Colorectal carcinomas (CRC) carry massive genetic and transcriptional alterations that influence multiple cellular pathways. The study of proteins whose loss-of-function (LOF) alters the growth of CRC cells can be used to further understand the cellular processes cancer cells depend upon for survival. |Colorectal carcinomas (CRC) carry massive genetic and transcriptional alterations that influence multiple cellular pathways. The study of proteins whose loss-of-function (LOF) alters the growth of CRC cell
WJSO | Download References | Outcomes of resection for colorectal cancer hepatic metastases stratified by evolving eras of treatment
www.wjso.com - 12/30/11
The outcomes and management of colorectal cancer (CRC) hepatic metastasis have undergone many evolutionary changes. In this study, we aimed to analyze the outcomes of patients with CRC hepatic metastasis in terms of the era of treatment. |The outcomes and management of colorectal cancer (CRC) hepatic metastasis have undergone many evolutionary changes. In this study, we aimed to analyze the outcomes of patients with CRC hepatic metastasis in terms of the era of treatment.
British Journal of Cancer - Abstract of article: Randomised phase-II trial of CAPIRI (capecitabine, irinotecan) plus bevacizumab vs FOLFIRI (folinic acid, 5-fluorouracil, irinotecan) plus bevacizumab as first-line treatment of patients with unresectable/me
www.nature.com - 1/12/12
The BJC is owned by Cancer Research UK, a charity dedicated to understanding the causes, prevention and treatment of cancer and to making sure that the best new treatments reach patients in the clinic as quickly as possible. The journal reflects these aims. It was founded more than fifty years ago and, from the start, its far-sighted mission was to encourage communication of the very best cancer research from laboratories and clinics in all countries. The breadth of its coverage, its editorial independenc
Sex-Specific Prevalence of Adenomas and Colorectal CancerReply, January 11, 2012, Ferlitsch and Trauner 307 (2): 143 JAMA
jama.ama-assn.org - 1/11/12
Letters. JAMA. 2012; 307( 2): 143-144. doi: 10.1001/jama.2011.1981. Sex-Specific Prevalence of Adenomas and Colorectal Cancer Reply. ... In Reply: Drs Roy and Bianchi suggest patient referral to screening colonoscopy should take into account additional
Arch Intern Med -- Young-Onset Colorectal Cancer: Is It Time to Pay Attention?, December 15, 2011, You et al. 0 (2011): archinternmed.2011.602v2
archinte.ama-assn.org - 12/15/11
Archives of Internal Medicine, a bi-monthly professional medical journal published by the American Medical Association, publishes original peer-reviewed research articles on internal medicine topics
 
MEDLINE
Targeted epidermal growth factor receptor therapy in malignant pleural mesothelioma: where do we stand?
pubmed.com - 11/1/11
cancer using small molecule tyrosine kinase inhibitors and in colorectal cancer using monoclonal anti-EGFR antibodies. ...
Red meat and colon cancer: should we become vegetarians, or can we make meat safer?
pubmed.com - 11/1/11
meats and red meat are at increased risk of colorectal cancer. This increase is significant but modest (20-30%). ... These additives and others still under study could provide an acceptable way to prevent colorectal cancer. ...
Gut microbiota and probiotics in colon tumorigenesis.
pubmed.com - 10/28/11
the emerging relationship between the microbiota and development of colorectal cancer as well as present evidence that microbial manipulation ...
Clinicopathologic significance of DNA mismatch repair protein defects and endometrial cancer in women 40years of age and younger
pubmed.com - 10/1/11
05) and had a family history suggestive of Lynch syndrome (P=0.001). ...
Information on the Internet about colorectal cancer: patient attitude and potential toward Web browsing. A prospective observati
pubmed.com - 10/1/11
cancer information. Most participants used the Google search engine. Only 13% of participants confirmed that colorectal cancer information ... more likely to use the Internet to find colorectal cancer information (p = 0.005) ...

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CLINICAL TRIALS
Computerized and Mailed Reminders in Increasing the Rate of Colorectal Cancer Screening in Adults With an Average Risk for Colorectal Cancer - Full Text View - ClinicalTrials.gov
www.clinicaltrials.gov -
Pilot Study of the National Colorectal Cancer Roundtable Toolbox (NCCRT) to Increase Colorectal Cancer Screening Rates - Full Text View - ClinicalTrials.gov
www.clinicaltrials.gov -
Educational Intervention With or Without Telephone Counseling in Increasing Colorectal Cancer Screening Compliance in Brothers and Sisters of Patients With Colorectal Cancer - Full Text View - ClinicalTrials.gov
www.clinicaltrials.gov -
A Study of Avastin in Combination With Chemotherapy for Treatment of Colorectal Cancer and Non-Small Cell Lung Cancer (ARIES) - Full Text View - ClinicalTrials.gov
www.clinicaltrials.gov -
Educational CD-ROM Compared With Standard Informed Consent for Patients With Colorectal Cancer or a Family History of Colorectal Cancer - Full Text View - ClinicalTrials.gov
www.clinicaltrials.gov -

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FROM PHYSICIANS PRACTICE
Tax Schemes Every Physician Should Avoid
Ike Devji, JD, January 31, 2012
The next 60 days marks the final push to sell physicians across the United States tax plans of both good and questionable value.
Boosting Collections at Your Medical Practice: Whose Job Is It?
P.J. Cloud-Moulds, January 28, 2012
Embrace the relationship between your billing company and your medical practice staff.
Managing Difficult Medical Practice Employees
Shelly K. Schwartz, January 27, 2012
Tips for transforming immature staff members into great employees.
Prevent Physician Distraction When Using mHealth Technology
Aubrey Westgate, January 25, 2012
As more and more physicians use handheld mobile technology in their day-to-day work, some critics are raising concerns about “distracted doctoring.”
Can That Applicant Do the Job at Your Medical Practice?
Karen Zupko, January 25, 2012
If like many communities, yours has significant numbers of non-English speaking people with whom neither you nor your staff are able to converse, your practice is at a serious disadvantage.
 
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