Panelists discuss insights from the MARIPOSA study on first-line treatment options for EGFR-mutant metastatic non–small cell lung cancer (NSCLC), highlighting the efficacy of amivantamab-lazertinib over osimertinib, the importance of managing adverse events, adherence to National Comprehensive Cancer Network guidelines, and the need for patient engagement in treatment discussions to address unmet needs.

Lyudmila Bazhenova, MD, and Frederico Albrecht, MD, consider when to refer to a clinical trial data and how to use real-world evidence when making treatment decisions for patients with EGFR-mutated non–small cell lung cancer based on a recent publication by Bassel Nazha, MD, MPH.

Expert oncologists review safety/efficacy data behind mobocertinib, a small molecule tyrosine kinase inhibitor, in patients with EGFR exon 20 insertion–positive metastatic non–small cell lung cancer.

Expert perspectives on recent updates in the use of proteasome inhibitors for patients with multiple myeloma.

Martin Dietrich, MD, PhD, Sara Tolaney, MD, MPH, and Gregory Vidal, MD, PhD review recent data from the TROPiCS-02 trial on sacituzumab govitecan and discuss the clinical implications of these findings.

Daniel Petrylak, MD and Donald Barry Boyd, MD, MS review a publication presenting use of avelumab maintenance in patients with locally advanced or metastatic urothelial carcinoma in real-world practice and discuss their own experiences with the regimen.

Rahul Gosain, MD; Rohit Gosain, MD, and Daniel Ahn, DO, analyze pivotal studies in hepatocellular carcinoma, including HIMALAYA, IMbrave 150, and CheckMate 9DW, discussing study designs, outcomes, patient characteristics, and efficacy data.

Panelists discuss how nivolumab plus relatlimab may offer a similar efficacy to nivolumab plus ipilimumab in advanced melanoma, with a potentially better safety profile, based on an indirect treatment comparison using data from the RELATIVITY-047 and CheckMate 067 trials.

Medical Oncologists Sandip Patel, MD and Helena Yu, MD discuss data from the HERTHENA-Lung01 trial investigating HER3-DXd in EGFR-mutated NSCLC and the evolving treatment landscape in NSCLC.

David Ilson, MD, PhD; Sunnie Kim, MD; and Raji Shameem, MD,​ discuss how first-line nivolumab plus chemotherapy has demonstrated sustained survival benefits in advanced gastric cancer, with PD-L1 combined positive scores helping guide patient selection. Long-term safety data support its role as standard of care, particularly benefiting patients with PD-L1–high disease, though unmet needs remain in subgroups with PD-L1–low disease.

Panelists discuss how myelofibrosis management involves a blend of medications, supportive care, and potential stem cell transplantation, with a focus on Janus kinase inhibitors and investigational agents like pelabresib for modifying disease progression, as well as the findings from the MANIFEST-2 trial regarding spleen volume reduction and biomarker data.

Key opinion leaders review recent data from the ASCO 2023 annual meeting surrounding the MonumenTAL-1 and RedirecTT-1 trials, considering their impact on the real-world management of relapsed/refractory multiple myeloma.

Martin Dietrich, MD, PhD ​and Roy Herbst, MD ​discuss how the evolving first-line treatment options for EGFR-mutated non-small cell lung cancer, including osimertinib monotherapy, osimertinib plus chemotherapy, and amivantamab plus lazertinib, have reshaped the landscape, with a strong emphasis on overall survival benefits and the role of combination therapies in improving patient outcomes.

A panel of experts on multiple myeloma review data from the MonumenTAL-1 clinical trial investigating talquetamab and provide comprehensive insights on treating patients and managing adverse effects.

Suzanne Fanning, DO, and Joshua Richter, MD, discuss clinical implications of a real-world study of ixazomib, lenalidomide, and dexamethasone compared with lenalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma.

Experts collaborate to share and reflect on data from an eNRGy1 global registry study, which analyzed therapy in NRG1 fusion–driven lung cancers.

Panelists discuss how the CLEAR trial highlights the efficacy of lenvatinib plus pembrolizumab over sunitinib in advanced renal cell carcinoma, focusing on patterns of progression and the implications for subsequent therapy.

Expert hematologist-oncologists share insight on the E7438-G000-101 clinical trial and consider use of tazemetostat, an EZH2 inhibitor, in relapsed/refractory follicular lymphoma.

Alexander Spira, MD, PhD, FACP, FASCO​, and Randi Rabin, MPH, MSc,​ PA-C, discuss how proactive dermatologic adverse event management—specifically through the COCOON protocol—enhances treatment adherence, reduces toxicity, and improves quality of life for patients with EGFR-mutant non–small cell lung cancer receiving amivantamab plus lazertinib.

Experts discuss the 3-year follow-up results from the phase 3 TRANSFORM study, comparing liso-cel with standard of care with salvage chemotherapy followed by autologous stem cell transplant (ASCT) as second-line treatment in patients with relapsed/refractory large B-cell lymphoma (R/R LBCL).

In this journal club-like program, Sara A. Hurvitz, MD, and Steven E. Vogl, MD, discuss a recently published paper about third-line treatments for HER2-positive breast cancer and provide insight about its implications for clinical practice.

In this program, George Ansstas, MD, and Firas B. Badin, MD, discuss a recently published paper on ctDNA for analysis of immunotherapy efficacy in individual patients with solid tumor malignancies.

Marwan G. Fakih, MD, and Atif Hussein, MD, MMM, FACP, review data from the SUNLIGHT study and discuss their impact on the overall treatment landscape in metastatic colorectal cancer.

A panel of oncologists reviews a publication by Motzer et al. (2021) on data from the CLEAR trial studying lenvatinib plus pembrolizumab or everolimus for advanced renal cell carcinoma treatment and discuss the clinical implications of the results.

Stacy A. Cohen, MD, and Mark Lewis, MD review results from the GALAXY study on circulating tumor DNA dynamics in CRC that were recently presented at ASCO GI 2022, and discuss the clinical implications of the findings.

Expert oncologists Aditya Bardia, MD, MPH, and Alison Conlin, MD, review clinical data behind the use of sacituzumab govitecan in metastatic TNBC from the phase 3 ASCENT study.

Amrita Y. Krishnan, MD, and Binod Dhakal, MD, review recent data from the MajesTEC-1 trial of teclistamab in patients with relapsed/refractory multiple myeloma and have a discussion on evolving therapeutic practices.

Joshua K. Sabari, MD, and Martin Dietrich, MD, PhD, examine both the evolution of first-line EGFR TKIs as standard treatment for EGFR-mutated metastatic non-small cell lung cancer and the ongoing clinical challenges in managing resistance, toxicities, and treatment sequencing in this space.

Mike J. Pishvaian, MD, PhD; Stacey Cohen, MD; and Mark Lewis, MD, FASCO, discuss how recent advancements in circulating tumor DNA (ctDNA) and minimal residual disease (MRD) testing are revolutionizing colorectal cancer management across the care continuum, from early detection to treatment selection and monitoring, with key insights from major clinical trials like DYNAMIC and GALAXY informing more personalized and effective treatment strategies.

Key takeaways from a recent study of tipifarnib as treatment for recurrent and/or metastatic mHRAS head and neck squamous cell carcinoma.

Gastrointestinal medical oncologists review recent clinical research and have a comprehensive discussion on the use of circulating tumor DNA (ctDNA) as a predictive biomarker in patients with colorectal cancer.

Drs Liliana Bustamante and Richard Kim review “Detection of Molecular Residual Disease Using Personalized Circulating Tumor DNA Assay in Patients With Colorectal Cancer Undergoing Resection of Metastases,” and consider how to apply the paper’s findings into clinical practice.

Expert perspectives on a recent clinical trial readout indirectly comparing acalabrutinib and zanubrutinib in patients with relapsed/refractory chronic lymphocytic leukemia.

Expert oncologists review key data from the CRESTONE trial, which observed the safety and efficacy of seribantumab, an anti-HER3 IgG2 monoclonal antibody, in solid tumors with NRG1 fusions.

Nelson J. Chao, MD, MBA, and Michael Grunwald, MD review Acute Graft-Versus-Host Disease diagnosis and treatment before engaging with two REACH2 trial post hoc analyses, sharing clinical implications and key takeaways.

Steven Finkelstein, MD, DABR, FACRO, and Louis J. Mazzarelli, MD, react to the article, “A Prospective Head-to-Head Comparison of 18F-Fluciclovine With 68Ga-PSMA-11 in Biochemical Recurrence of Prostate Cancer in PET/CT,” by Pernthaler B, et al.

Larysa Sanchez, MD; and Samantha Shenoy, MSN, NP, discuss the management of adverse events with bispecific antibodies like GPRC5D and talquetamab while providing guidance on optimizing treatment outcomes and supportive care, as well as offering advice for managing toxicities and future perspectives on relapsed/refractory multiple myeloma.

Joshua K. Sabari, MD, and Helena A. Yu, MD, discuss the evolving treatment landscape in non–small cell lung cancer for patients with EGFR exon 20 insertion mutations and results from a real-world study that may impact the field.

John Marshall, MD​, and Mark Lewis, MD​, discuss how circulating tumor DNA (ctDNA) testing in colorectal cancer offers promising clinical utility across the care continuum, from early detection to treatment monitoring, with trials like BESPOKE and SWOG 80702 demonstrating its potential to guide personalized therapy decisions, predict outcomes based on minimal residual disease status, complement traditional imaging in challenging cases, and transform patient care through a patient-centric approach that requires ongoing research to establish standardized protocols.

Brian Helfand, MD, PhD, and Steven Finkelstein, MD, FACRO, provide insight on the results and clinical implications of the EMPIRE-1 trial in prostate cancer.

Expert perspectives on the phase III MARIPOSA-2 trial results evaluating amivantamab-based regimens in EGFR-mutant NSCLC after osimertinib progression. The discussion covers efficacy, safety, clinical implications, and future directions featuring Martin Dietrich, MD; Ticiana Leal, MD, and Sandip P. Patel, MD.

Expert hematologist-oncologists Thomas Leblanc, MD, and Bhumika Patel, MD, review clinical data behind the long-term use of tagraxofusp and share their own experience.

Experts discuss the analyses on the impact of tumor burden at progression and changes in IMDC risk scores in the CLEAR trial, providing prognostic insights in advanced RCC with lenvatinib plus pembrolizumab.

Shilpa Gupta, MD, and Vinit Makkar, MD, discuss the treatment patterns and disease management of locally advanced/metastatic urothelial carcinoma, with a focus on data from the US physician-based PARADIGM study.

Expert hematologist-oncologists review data from the MajesTEC-1 trial and discuss the optimal management of cytokine release syndrome in patients on therapy for relapsed/refractory multiple myeloma.

Dr. Joseph Mikhael and Dr. Hakan Kaya review key efficacy and safety data for the combination of Selinexor, Carfilzomib and Dexamethasone in R/R MM and discuss optimal dosing and adverse event management strategies for selinexor.

Key opinion leaders examine the current frontline treatment options for mantle cell lymphoma while identifying critical unmet patient needs requiring attention.

In this program, D. Ross Camidge, MD, PhD, and Alexander Spira, MD, PhD, discuss a recently published paper on the anti-HER3 monoclonal antibody seribantumab in the treatment of tumor samples with oncogenic NRG1 fusions.

Neeraj Agarwal, MD, and Simon Chowdhury, MD, review final results from the TITAN study of apalutamide in patients with mCSPC and discuss the clinical implications of the findings.

Experts discuss use of ponatinib in chronic myeloid leukemia and optimal dosing.

Dr Joshua Richter and Dr Peter Forsberg review key trial data and dosing strategies for selinexor based combinations.

Panelists discuss how the CARTITUDE-4 study data highlights the significant survival benefits of ciltacabtagene autoleucel compared to with standard of care in patients with lenalidomide-refractory multiple myeloma, emphasizing its potential to reshape treatment paradigms in this challenging population.

Drs. Gupta and Brown discuss a recently published paper by Grivas et al. (2019) on the use of checkpoint inhibitors for maintenance therapy to prolong the benefits of frontline therapy while minimizing toxicity in solid tumors.

Martin H. Voss, MD, and Moshe C. Ornstein, MD, review significant renal cell carcinoma research developments presented at ASCO 2024, highlighting data and insights poised to reshape the disease's treatment landscape.

Michael R. Bishop, MD, and Bruce B. Bank, MD, review results from the ELEVATE-RR noninferiority trial on acalabrutinib versus ibrutinib in CLL, and discuss the clinical implications of the findings.

Toni Choueiri, MD, and Rohit Gosain, MD present 3-year follow-up data from the CheckMate 9ER trial, discussing a variety of outcomes concerning the use of nivolumab plus cabozantinib in patients with advanced renal cell carcinoma, and sharing clinical insights for community oncologists.

Hematologic oncology specialists review recent data from the PERSEUS trial analyzing minimal residual disease in patients with newly diagnosed multiple myeloma who receive DARA-VRd.

Panelists discuss managing infusion-related reactions with amivantamab and lazertinib, compare these reactions with those from other treatments, and review SKIPPirr data to provide insights on incorporating prophylactic dexamethasone 8 mg, addressing implementation barriers, and educating patients.