TEST YOUR IMAGE IQ A 58-year-old male presents with complaints of bloating, vague abdominal pain, and dark black stools. A gastroenterologist recommends upper and lower endoscopy. A mass of about 11×12 mm is removed from the stomach. The most likely diagnosis is: A. Desmoid tumor B. Inflammatory fibroid polyp C. Schwannoma D. Gastrointestinal stromal tumor
CONFERENCE REPORT Dr. Mark Kris discusses the news highlighted at ASCO's 2011 Annual Meeting that covers research on managing cancer as a chronic disease, and includes information on advances in treatment for gastrointestinal stromal tumors (GIST). Video source: cancer.net
Before and After CT Scan of GIST Patient Using Therapy
REVIEW ARTICLEOncology Vol. 17 No. 11 The molecular and genomic determinants of response/resistance patterns are the subject of ongoing studies, and adjuvant studies are also under way. The initial evaluations of imatinib provide proof of concept for the hypothesis-driven design of selective molecularly targeted therapies for solid tumor malignancies.
REVIEW ARTICLEOncology Vol. 23 No. 1 This review describes the current multidisciplinary management of gastrointestinal stromal tumor (GIST), which is the most common sarcoma of the gastrointestinal tract. Before 2001, surgery was the only effective therapy for GIST.
REVIEW ARTICLEOncology Vol. 22 No. 2 The impact of neoadjuvant drug therapy needs to be further classified and explored. With additional evaluation of other tyrosine kinase inhibitors and novel therapies against other molecular markers, the treatment paradigm for this malignancy should continue to evolve.
The FDA has granted imatinib full approval as an adjuvant treatment following surgical removal of CD117-positive gastrointestinal stromal tumors in adult patients. This comes after results from a phase III trial showed that patients taking imatinib for 36 months had a 5-year overall survival of 92%,... More »
A 16-year-old female patient with repeated vomiting. First X-ray of the abdomen shows multiple dilated small bowel loops, represent distal small bowel obstruction.... More »
The soft-tissue sarcomas are a group of rare but anatomically and histologically diverse neoplasms. This is due to the ubiquitous location of the soft tissues and the nearly three dozen recognized histologic subtypes of soft-tissue sarcomas. More »
Gastric cancer is more common than esophageal cancer in Western countries but is less fatal. More than 21,000 new cases of gastric cancer will be diagnosed in the United States in the year 2010, with 10,750 deaths expected. More »
A 58-year-old male presents with chief complaints of bloating, vague abdominal pain, and dark black stools. He is referred to a gastroenterologist who recommends upper and lower endoscopy. More »
Sunitinib (Sutent) has been approved as the first anti-VEGF (vascular endothelial growth factor) agent for neuroendocrine tumors (NET) in patients with unresectable locally advanced or metastatic disease. More »
"Kinome" is the word to know this year in oncology, because it has begun to reveal molecules that some tumors are relying on to survive, which until now we had no idea were involved in cancer or which we hardly knew at all. More »
Gastric cancer is more common than esophageal cancer in Western countries but is less fatal. More than 21,130 new cases of gastric cancer will be diagnosed in the United States in the year 2009, with 10,620 deaths expected. Worldwide, gastric cancer represents approximately 930,000 new cases and... More »
Gastrointestinalstromal tumors (GISTs) and adenocarcinoma are distinct neoplasms originating from different cell layers. Approximately 20% of patients with GIST develop other cancers.|Gastrointestinalstromal tumors (GISTs) and adenocarcinoma are distinct neoplasms originating from different cell layers. Approximately 20% of patients with GIST develop other cancers.
The BJC is owned by Cancer Research UK, a charity dedicated to understanding the causes, prevention and treatment of cancer and to making sure that the best new treatments reach patients in the clinic as quickly as possible. The journal reflects these aims. It was founded more than fifty years ago and, from the start, its far-sighted mission was to encourage communication of the very best cancer research from laboratories and clinics in all countries. The breadth of its coverage, its editorial independenc
Ovarian cancer has the highest mortality rate of all gynecologic malignancy. The receptor tyrosine kinases (RTKs), including EGFR, ERBB2, PDGFR, VEGFR and MET, are activated in subsets of ovarian cancer, suggesting that these kinases might represent novel therapeutic targets. However, clinical trials have not or just partially shown benefit to ovarian cancers treated with EGFR, ERBB2, or PDGFR inhibitors. Despite multiple RTK activation in ovarian cancer pathogenesis, it is unclear whether transforming ac
Gastrointestinalstromal tumors (GISTs) and adenocarcinoma are distinct neoplasms originating from different cell layers. Approximately 20% of patients with GIST develop other cancers.|Gastrointestinalstromal tumors (GISTs) and adenocarcinoma are distinct neoplasms originating from different cell layers. Approximately 20% of patients with GIST develop other cancers.
Many recently developed cancer drugs target discrete molecular aberrations or pathways in tumor cells and consequently are active on a subset of the patient population. ... For example, the benefits of adjuvant chemotherapy for stage II colon cancer have
'What They Should Really Teach in Medical School' Julie Schopps, MD , February 6, 2012 The North Carolina-based pediatrician weighs in on why she thinks the real learning doesn't take place until students are out of the classroom.
Improve EHR Systems by Rethinking Medical Billing Daniel Essin, MA, MD, February 6, 2012 Separating billing-related data from other clinical documentation and transmitting it to a billing system is not difficult …no matter how the charting is done.
A 16-year-old female patient with repeated vomiting. First X-ray of the abdomen shows multiple dilated small bowel loops, represent distal small bowel obstruction.... 
