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Melanoma

Developments in the Screening and Prognostication of Melanoma

In this peer-to-peer discussion, Ahmad A. Tarhini, MD, PhD, of the UPMC Hillman Cancer Center, and Sancy Leachman, MD, PhD, of the OHSU Knight Cancer Institute, review the current strategies for managing patients with melanoma, including screening and prognosis for high-risk patients and how to choose the best therapies to avoid toxicities and treatment resistance.

Melanoma

In this interview we discuss the effect of the gut microbiome on responses and survival outcomes in metastatic melanoma patients treated with anti–PD-1 immunotherapies.

Treatment with single-agent bevacizumab resulted in an improved disease-free interval in patients with resected melanoma, but no increase in overall survival compared with observation.

Patients with node-positive intermediate-thickness melanoma had an increased rate of regional disease control when undergoing completion lymph-node dissection for sentinel node metastases, however, there was no increase in melanoma-specific survival.

This peer-to-peer discussion reviews the current strategies for managing patients with melanoma, including screening and prognosis for high-risk patients and how to choose the best therapies to avoid toxicities and treatment resistance.

Treatment with the combination of the MEK inhibitor binimetinib and the BRAF inhibitor encorafenib resulted in a superior progression-free survival for patients with advanced, unresectable BRAF-mutated melanoma compared with treatment with encorafenib alone.

More than one-third of patients with metastatic uveal melanoma had objective tumor regression when treated with adoptive transfer of autologous tumor-infiltrating lymphocytes.

A study has identified several characteristics that can help detect seborrheic keratosis–like melanomas using dermoscopy, which can help to diagnose melanoma.

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