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Melanoma

ASCO 2016 Genitourinary Cancers Symposium

Cancer Network presents exclusive coverage from the American Society of Clinical Oncology (ASCO) 2016 Genitourinary Cancers Symposium, held January 7–9 in San Francisco. We’ll bring you reports as we cover the latest research, trials, scientific advances, and controversies that are changing the way genitourinary cancers are managed and treated.

Melanoma

Adjuvant high-dose interferon alfa-2b did not improve survival in melanoma patients with single tumor–positive lymph nodes found with sentinel lymph node biopsy.

A median overall survival of longer than 2 years was achieved in a group of patients with metastatic melanoma assigned to treatment with the combination of dabrafenib and trametinib.

Women younger than 40 may be more likely to frequent indoor tanning, and those who do are between two and six times more likely to develop melanoma, according to a new study.

Long-term study results show that a wider surgical margin for cutaneous melanomas greater than 2-mm thick improved melanoma-specific survival vs a 1-cm margin.

In this review, we discuss current management strategies, as well as future directions, for the management of uveal and conjunctival melanoma.

There has been rapid progress in the treatment of metastasis associated with cutaneous melanoma, including impressive results achieved with targeted molecular therapies and immunotherapies, and it is possible (but still unproven) that patients with metastasis from conjunctival and eyelid melanomas may benefit from these new therapies.

The FDA recently expanded its approval of pembrolizumab (Keytruda) to include the initial treatment of patients with unresectable or metastatic melanoma.

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  • When you inspect moles, pay special attention to their sizes, shapes, edges, and color. A handy way to remember these features is to think of the A, B, C, D, and E of skin cancer—asymmetry, border, color, diameter, and evolving.

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