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Isolated Limb Perfusion for Stage III Melanoma: Does It Still Have a Role in the Present Era of Effective Systemic Therapy?

Effective systemic therapy for the treatment of stage III melanoma has emerged. Whether this influences treatment choice in stage III melanoma patients with in-transit metastases is the subject of this review.


A study has identified several characteristics that can help detect seborrheic keratosis–like melanomas using dermoscopy, which can help to diagnose melanoma.

A nivolumab/ipilimumab combination significantly improved overall survival for advanced melanoma patients.

This video examines phase II results of a single-arm trial that tested checkpoint inhibition plus the IDO–pathway inhibitor indoximod in patients with melanoma.

The combination of an intratumoral injection of CVA21 and ipilimumab has demonstrated durable response with minimal toxicity in patients with advanced melanoma.

The MEK inhibitor binimetinib improved progression-free survival compared with dacarbazine in patients with NRAS-mutant melanoma, according to the results of the NEMO trial.

Although long-term melanoma survivors were more likely to report healthier levels of ultraviolet radiation exposure and sun protection behaviors than controls, some still reported indoor tanning or intentionally seeking sun to tan.

The identification of ugly duckling nevi using a whole-body skin examination for intrapatient comparative analysis improves accuracy of melanoma detection.


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