Sarcoma

This article provides an extensive review of patient selection criteria and surgical approaches, as well as of controversies regarding resection for metastatic sarcoma.
• Thoracic Metastases From Sarcoma: a Commentary
• Comments Regarding Lung Metastasis Surgery for Sarcoma
• Resection of Pulmonary Metastases

This case shows the importance of searching for antineural antibodies in oncologic patients with new neurologic deficits, and of having a judicious workup for occult malignancies in patients with known antineural antibodies.
• Unraveling the Mystery of a Supraclavicular Mass

This review describes the current multidisciplinary management of gastrointestinal stromal tumor (GIST), which is the most common sarcoma of the gastrointestinal tract. Before 2001, surgery was the only effective therapy for GIST.
• Perioperative Tyrosine Kinase Inhibitors for GIST: Further Investigation?
• Controversies in the Surgical Management of GIST in the Era of Imatinib

Our case illustrates the fact that MDS-associated GS can be treated palliatively with radiation and hypomethylating agents in an appropriate setting. With the growing geriatric patient population, effective treatment options are needed in this disease.

The impact of neoadjuvant drug therapy needs to be further classified and explored. With additional evaluation of other tyrosine kinase inhibitors and novel therapies against other molecular markers, the treatment paradigm for this malignancy should continue to evolve.
• Treatment of GIST: Clarifying the Data

A 37-year-old man presented with a mass in his right ankle. Resection of the mass was performed. What is the most likely result of a molecular study, and based on the histological and molecular features of this tumor, what is you diagnosis?

A 67-year-old African American female presented with an approximately 18-month history of a solitary, asymptomatic lesion on the right leg. This patient most likely has what tumor on her leg?

A 17-year-old female carries a diagnosis of Li-Fraumeni syndrome (a rare autosomal dominant syndrome) and presents with a large mass in the right shoulder. The mass is excised.

A 7-year-old girl with hereditary multiple exostosis presents with a growing painful mass on her right femur. The following is an H&E stained slide of the mass.