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PRACTICE GUIDELINES
National Guideline Clearinghouse | Trabectedin for the treatment of advanced soft tissue sarcoma.
www.guidelines.gov -
National Guideline Clearinghouse | Bone cancer and soft tissue sarcoma. In: Suspected cancer in primary care: guidelines for investigation, referral and reducing ethnic disparities.
www.guidelines.gov -
pats200811120st 1..7
www.thoracic.org -
 
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Sarcoma
 
SARCOMA
November 15, 2011
Comments Regarding Lung Metastasis Surgery for Sarcoma
In this issue of ONCOLOGY, Kon and Martin review the difficult issue of lung metastasis from sarcoma and its management. More »
November 15, 2011
Thoracic Metastases From Sarcoma: a Commentary
Surgical resection of isolated pulmonary metastases has been incorporated into the management of cancer for more than 70 years. However, many questions still remain concerning indications, technique,... More »
November 15, 2011
Resection for Thoracic Metastases From Sarcoma
Sarcomas may arise from nearly any embryonic mesodermal tissue and constitute approximately 1% of all newly diagnosed malignancies annually. More »
June 9, 2011
With Pediatric Sarcoma, No Need for Bone Scans. PET/CT Sufficient.
Children with pediatric sarcoma can be spared the additional radiation of single photon emission computed tomorgraphy (SPECT). PET/CT imaging alone does the trick, according to a study presented this... More »
May 26, 2011
Endometrial Stromal Sarcoma
Endometrial stromal sarcoma (ESS) is a rare malignant tumor of the endometrium, occurring in the age group of 40-50 years. More »
September 1, 2010
Influx of funding impels collaborative explorations to study sarcoma as behavior model for other cancers
This rare cancer finally sheds its FDA designation as an orphan disease. More »
July 28, 2009
PET/CT indicates if early neoadjuvant Rx is making the grade in sarcoma patients
Using FDG-PET/CT, a multidisciplinary team has been able to determine within a short period of time whether neoadjuvant therapy for soft-tissue sarcoma is working. More »
October 1, 2008
Four Types of Kaposi Sarcoma
A 46-year-old man with AIDS (CD4+ cell count, 150/μL) presented with a painful nodular lesion on the plantar surface of his right foot. The lesion had appeared 1 month earlier as a painless, 1-cm,... More »
October 1, 2008
Classic Kaposi Sarcoma
For 1 month, a 66-year-old man had had an asymptomatic lesion on the dorsum of his left hand. The flesh-colored, dome-shaped, maroon-crusted lesion measured 0.7 cm and was located over the fourth... More »
October 1, 2008
African Kaposi Sarcoma
An 84-year-old Ethiopian woman presented with tender, violaceous, nonblanching nodules that had coalesced into plaques on the soles of both of her feet over the past 3 months. Similar discrete nodules... More »
Showing 1 - 10 of 81 results.
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TEST YOUR IMAGE IQ

17-Year-Old Patient With Li-Fraumeni Syndrome Presents With Large Mass in the Right Shoulder
October 24, 2011

A 17-year-old female carries a diagnosis of Li-Fraumeni syndrome (a rare autosomal dominant syndrome) and presents with a large mass in the right shoulder. The mass is excised.

7-Year-Old Girl With Hereditary Multiple Exostosis Presents With a Painful Mass on Her Right Femur
October 12, 2011

A 7-year-old girl with hereditary multiple exostosis presents with a growing painful mass on her right femur. The following is an H&E stained slide of the mass.

 
MEDLINE
Errors in a study of proportions of Kaposi sarcoma, selected non-Hodgkin lymphomas, and cervical cancer in the United States occurring in persons with AIDS, 1980-2007.
pubmed.gov - 10/12/11
Interplay between steroid receptors and neoplastic progression in sarcoma tumors.
pubmed.gov - 11/1/11
Steroid hormones are expressed at low levels in mesenchymal cells and are highly expressed in soft tissue sarcoma. In human soft tissue fibrosarcoma cell line (HT-1080), the epidermal growth factor (EGF) stimulates the express of matrix metal (MMPs) expression through a Src-dependent mechanism. In human fibrosarcomas, increased expression of MMPs correlates with the metastatic progression. Our recent data in human breast cancer cell line MCF-7, demonstrates that EGF stimulates estradiol receptor (ER) phosphorylation on tyrosine at position 537 thereby promoting the association of a complex among EGF receptor (EGFR), androgen receptor (AR), ER, and Src that activates EGF-dependent signaling pathway. In the present study, we demonstrate that, in HT-1080 cells, the Src kinase activity is involved in EGFR phosphorylation and this activity is regulated by an interplay between Src, steroid receptors, and EGFR. In these cells, estradiol (E(2) )/ER and synthetic androgen (R1881)/AR
Delineation of a core RNA element required for Kaposi's sarcoma-associated herpesvirus ORF57 binding and activity.
pubmed.gov - 10/25/11
The Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is an essential multifunctional regulator of gene expression. ORF57 interaction with RNA is necessary for ORF57-mediated posttranscriptional functions, but little is known about the RNA elements that drive ORF57-RNA specificity. Here, we investigate the cis-acting factors on the KSHV PAN RNA that dictate ORF57 binding and activity. We show that ORF57 binds directly to the 5' end of PAN RNA in KSHV-infected cells. Furthermore, we employ in vitro and cell-based assays to define a 30-nucleotide (nt) core ORF57-responsive element (ORE) that is necessary and sufficient for ORF57 binding and activity. Mutational analysis of the core ORE further suggests that a 9-nt sequence is a specific binding site for ORF57. These studies provide insight into ORF57 specificity determinants and lay a foundation for future analyses of cellular and viral ORF57 targets.
Classic Kaposi sarcoma.
pubmed.gov - 9/20/11
A unique case of a sarcoma arising in a testicular non-seminomatous mixed germ cell tumour with a predominant yolk sac component.
pubmed.gov - 10/1/11
We present a unique case of a sarcoma arising in a testicular non-seminomatous mixed germ cell tumour with a predominant yolk sac tumour (YST) component. This is the first case reported in which a sarcoma is linked to YST of the testis in a patient not having undergone prior chemotherapy. This finding confirms the ability of YST to contain sarcoma; it underlies its importance for urologists, oncologists and pathologists to be aware of this phenomenon and to modify treatment strategies appropriately.



 
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FROM PHYSICIANS PRACTICE
'What They Should Really Teach in Medical School'
Julie Schopps, MD , February 6, 2012
The North Carolina-based pediatrician weighs in on why she thinks the real learning doesn't take place until students are out of the classroom.
Improve EHR Systems by Rethinking Medical Billing
Daniel Essin, MA, MD, February 6, 2012
Separating billing-related data from other clinical documentation and transmitting it to a billing system is not difficult …no matter how the charting is done.
Keeping Your Medical Practice’s Accounts Receivable on Track
P.J. Cloud-Moulds, February 4, 2012
Here are the minimum reports you should be running to keep an eye on your practices A/R.
Healthcare Providers Play Crucial Role in Helping Victims of Abuse
Stephen Hanson, PA-C , February 3, 2012
I would urge each and every one of you to be familiar with the warning signs of abuse, and the resources available to you all as healthcare providers.
Protecting Your Medical Practice's Data
Marisa Torrieri, February 3, 2012
Here's the scoop on how to implement a good data-backup plan at your office.
 
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