Sarcoma

We describe areas where major inroads were initially achieved by targeting angiogenesis and by unraveling pathways in the heterogeneous tumors of mesenchymal origin—spurred by the identification of c-Kit–activating mutations in GIST and the regressions that ensued when tumors harboring these mutations were exposed to the tyrosine kinase inhibitor imatinib (Gleevec).
• Improving Harmonious Precision
• Targeted Therapy for Cancer: Asking the Right Questions

This article provides an extensive review of patient selection criteria and surgical approaches, as well as of controversies regarding resection for metastatic sarcoma.
• Thoracic Metastases From Sarcoma: a Commentary
• Comments Regarding Lung Metastasis Surgery for Sarcoma
• Resection of Pulmonary Metastases

This case shows the importance of searching for antineural antibodies in oncologic patients with new neurologic deficits, and of having a judicious workup for occult malignancies in patients with known antineural antibodies.
• Unraveling the Mystery of a Supraclavicular Mass

This review describes the current multidisciplinary management of gastrointestinal stromal tumor (GIST), which is the most common sarcoma of the gastrointestinal tract. Before 2001, surgery was the only effective therapy for GIST.
• Perioperative Tyrosine Kinase Inhibitors for GIST: Further Investigation?
• Controversies in the Surgical Management of GIST in the Era of Imatinib

Our case illustrates the fact that MDS-associated GS can be treated palliatively with radiation and hypomethylating agents in an appropriate setting. With the growing geriatric patient population, effective treatment options are needed in this disease.

A 45-year-old man presented with swelling of the parotid gland. At physical examination a mass at the level of the parotid gland was found. Surgical resection of the mass was performed. What is your diagnosis?

A 47-year-old male with complaints of chronic abdominal pain and episodes of flushing presents for evaluation. What is your diagnosis?

A 42-year-old woman undergoes total hysterectomy due to uterine leiomyomata. A fallopian tube small tumor of about 1.5 cm is identified. What is your diagnosis?

A 34-year-old woman presents with pain in her left chest. Radiographic imaging shows the presence of nodules in the pleural surface. Surgical excision is performed. What is your diagnosis?