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News
Medical News: ASCO: Next Gen Kinase Inhibitors Improve First-Line CML Outcomes - in Meeting Coverage, ASCO from MedPage Today
www.medpagetoday.com - 6/4/10
dasatinib and nilotinib are FDA approved for use in chronic myeloid leukemia no longer responding to imatinib. ... Kantarjian H et al "Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia" N Engl J Med ...
Medical News: FDA Okays New First-Line Therapy for Rare Leukemia - in Product Alert, Prescriptions from MedPage Today
www.medpagetoday.com - 6/18/10
rare blood and bone marrow disorder Philadelphia chromosome positive chronic phase chronic myeloid leukemia (Ph+ CP-CML). ...
Medical News: ASCO: Hedgehog Drug Stirs Hope for Some Pediatric Brain Tumors - in Meeting Coverage, ASCO from MedPage Today
www.medpagetoday.com - 6/5/10
Imatinib revolutionized survival rates in chronic myeloid leukemia (CML) by attacking a specific kinase mutated ...

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For Patients
Chronic myelogenous leukemia: Treatments and drugs - MayoClinic.com
www.mayoclinic.com - 7/7/10
Chronic myelogenous leukemia: Complications - MayoClinic.com
www.mayoclinic.com - 7/7/10
Chronic myelogenous leukemia (CML): MedlinePlus Medical Encyclopedia
www.nlm.nih.gov - 6/24/10

 

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Chronic Myeloid Leukemia
 
Latest Features
August 10, 2010
CML patients’ molecular response to nilotinib continues to deepen over time
Eighteen-month follow up supports lower-dose nilotinib as the new standard of care for newly diagnosed chronic myeloid leukemia. More »
August 10, 2010
Second-generation TKIs poised to succeed imatinib in newly diagnosed CML
Imatinib (Gleevec), the first-line standard of care in chronic myeloid leukemia, will become a generic drug in 2015, so the race is on to find a second generation of tyrosine kinase inhibitors (TKIs)... More »
March 22, 2010
Nilotinib Gets Priority Review for Newly Diagnosed Early CML
Novartis recently announced that nilotinib (Tasigna) has been granted priority review by the US Food and Drug Administration (FDA) for the treatment of adult patients with newly diagnosed Philadelphia... More »
March 15, 2010
Chronic myeloid leukemia
Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder resulting from the neoplastic transformation of the primitive hematopoietic stem cell. The disease is monoclonal in origin,... More »
November 10, 2009
Nilotinib Meets Primary Endpoint in Pivotal Trial Against Imatinib as First-Line Treatment in Chronic Myeloid Leukemia Patients
Novartis announced recently that nilotinib (Tasigna) 200-mg capsules met its primary endpoint in the first head-to-head comparison with the company’s groundbreaking drug imatinib mesylate (Gleevec)... More »
Showing 1 - 5 of 30 results.
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Clinical Trials
Imatinib (Gleevec(Registered Trademark)) to Treat Chronic Myelomonocytic Leukemia and Atypical Chronic Myelogenous Leukemia - Fu
www.clinicaltrials.gov - 7/6/10
Advanced Chronic Myelogenous Leukemia (CML) - Follow On: Study of BMS-354825 in Subjects With CML - Full Text View - ClinicalTri
www.clinicaltrials.gov - 7/14/10
Homoharringtonine Plus Low-Dose Cytarabine in Treating Patients With Newly Diagnosed Chronic Myelogenous Leukemia in Chronic Pha
www.clinicaltrials.gov - 7/30/10
Donor Lymphocytes to Prevent Graft-Versus-Host Disease in Patients With Chronic Myeloid Leukemia - Full Text View - ClinicalTria
www.clinicaltrials.gov - 7/27/10
Dasatinib (BMS-354825) in Subjects With Myeloid Blast Phase Chronic Myeloid Leukemia Resistant to or Intolerant of Imatinib Mesy
www.clinicaltrials.gov - 8/2/10
 
Journal Scan
Micro-RNA response to imatinib mesylate in patients with chronic myeloid leukemia -- Flamant et al. 95 (8): 1325 -- Haematologic
www.haematologica.org - 7/31/10
myeloid leukemia. Current first-line therapy for newly diagnosed chronic myeloid leukemia is imatinib mesylate which typically produces a rapid hematologic response. ... myeloid leukemia patients as compared to healthy subjects. Peripheral blood cells from chronic phase and blast crisis patients displayed ...
Early intervention during imatinib therapy in patients with newly diagnosed chronic-phase chronic myeloid leukemia: a study of t
www.haematologica.org - 7/31/10
Early intervention during imatinib therapy in patients with newly diagnosed chronic-phase chronic myeloid leukemia: a study of the Spanish PETHEMA group ... imatinib therapy was undertaken in 210 adults with chronic-phase chronic myeloid leukemia less than three months from diagnosis ...
The response to imatinib and interferon-{alpha} is more rapid than the response to imatinib alone: a retrospective analysis of 4
www.haematologica.org - 7/31/10
were the gold standard for treatment of early chronic phase chronic myeloid leukemia patients. The combination of IFN- with imatinib ... imatinib and interferon- and of 419 early chronic phase chronic myeloid leukemia patients treated with imatinib alone front-line. ...
NEJM -- Dasatinib versus Imatinib in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia
content.nejm.org - 6/4/10
Dasatinib versus Imatinib in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia Hagop Kantarjian M.D. Neil P. ... chronic-phase CML. In an exploratory single-institution phase 2 study involving patients with newly diagnosed chronic-phase CML dasatinib induced ...
NEJM -- Dasatinib versus Imatinib in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia
content.nejm.org - 6/16/10
Dasatinib versus Imatinib in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia Hagop Kantarjian M.D. Neil P. ... cytogenetic response and progression-free survival among patients with chronic myeloid leukemia (CML) in the chronic phase after failure ...

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Medline
A comment on Megakaryocytic blast crisis as a presenting manifestation of chronic myeloid leukemia.
pubmed.com - 8/31/10
title: A comment on Megakaryocytic blast crisis as a presenting manifestation of chronic myeloid leukemia. ...
Targeted therapy of chronic myeloid leukemia.
pubmed.com - 8/31/10
targeted therapy of Philadelphia-positive (Ph(+ )) chronic myeloid leukemia (CML) and has been shown to be ...
Occurrences of opportunistic infections in chronic myelogenous leukemia patients treated with imatinib mesylate.
pubmed.com - 8/31/10
title: Occurrences of opportunistic infections in chronic myelogenous leukemia patients treated with imatinib mesylate. ...
20646761 2010 08 02 2010 08 24 ...
Therapeutic options for patients with myelofibrosis in blast phase.
pubmed.com - 8/31/10
transform to acute leukemia referred to as myelofibrosis in blast phase (MF-BP). The outcome of patients ...
Testicular cancer developed in a chronic myeloid leukemia patient with a continued complete cytogenetic and molecular response t
pubmed.com - 8/31/10
title: Testicular cancer developed in a chronic myeloid leukemia patient with a continued ...
20359744 2010 08 02 2010 08 24 ...

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Other Journals
Micro-RNA response to imatinib mesylate in patients with chronic myeloid leukemia -- Flamant et al. 95 (8): 1325 -- Haematologic
www.haematologica.org - 7/31/10
myeloid leukemia. Current first-line therapy for newly diagnosed chronic myeloid leukemia is imatinib mesylate which typically produces a rapid hematologic response. ... myeloid leukemia patients as compared to healthy subjects. Peripheral blood cells from chronic phase and blast crisis patients displayed ...
Early intervention during imatinib therapy in patients with newly diagnosed chronic-phase chronic myeloid leukemia: a study of t
www.haematologica.org - 7/31/10
Early intervention during imatinib therapy in patients with newly diagnosed chronic-phase chronic myeloid leukemia: a study of the Spanish PETHEMA group ... imatinib therapy was undertaken in 210 adults with chronic-phase chronic myeloid leukemia less than three months from diagnosis ...
The response to imatinib and interferon-{alpha} is more rapid than the response to imatinib alone: a retrospective analysis of 4
www.haematologica.org - 7/31/10
were the gold standard for treatment of early chronic phase chronic myeloid leukemia patients. The combination of IFN- with imatinib ... imatinib and interferon- and of 419 early chronic phase chronic myeloid leukemia patients treated with imatinib alone front-line. ...
NEJM -- Dasatinib versus Imatinib in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia
content.nejm.org - 6/4/10
Dasatinib versus Imatinib in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia Hagop Kantarjian M.D. Neil P. ... chronic-phase CML. In an exploratory single-institution phase 2 study involving patients with newly diagnosed chronic-phase CML dasatinib induced ...
NEJM -- Dasatinib versus Imatinib in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia
content.nejm.org - 6/16/10
Dasatinib versus Imatinib in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia Hagop Kantarjian M.D. Neil P. ... cytogenetic response and progression-free survival among patients with chronic myeloid leukemia (CML) in the chronic phase after failure ...