Since the implementation of highly active antiretroviral
therapy (HAART) in the United States in 1996, the number of persons diagnosed
with acquired immunodeficiency syndrome (AIDS) and the number of deaths among
persons with AIDS have declined substantially. As a result, the number of
persons living with AIDS has increased.
This report describes changes in AIDS incidence, prevalence,
and deaths among persons with AIDS from January 1996 to December 2000.
Surveillance data indicate a slowing of declines in new AIDS diagnoses,
continued declines in deaths among persons with AIDS, and increases in the
number of persons living with AIDS. These findings indicate that AIDS continues
to place a burden on the health-care system in the United States and that access
to medical and preventive services must be improved to reduce the public health
impact of AIDS.
AIDS surveillance is conducted in all states, the District of
Columbia, and US territories; cases are reported to the Centers for Disease
Control and Prevention (CDC) by using a standard definition and form. In
addition, most states conduct human immunodeficiency virus (HIV) surveillance.
To estimate AIDS incidence and deaths of persons with AIDS through
December 2000, the CDC adjusted reported cases for reporting delays. The
HIV-exposure categories for cases reported initially without risk were estimated
from historical patterns of risk ascertainment and reclassification. AIDS
prevalence was estimated by subtracting cumulative deaths from cumulative AIDS
AIDS incidence increased rapidly throughout the 1980s, peaked
in the early 1990s, and then declined (Figure 1). The peak of new diagnoses in
1993 was associated with expansion of the AIDS surveillance case definition. In
1996, sharp declines in the incidence of AIDS were observed for the first time.
During 1998-1999, declines in AIDS incidence began to level. During 1999-2000,
essentially no change in AIDS incidence was observed; an estimated 40,907 new
AIDS cases were diagnosed in 1999, and an estimated 41,113 in 2000.
During 1996-2000, the incidence of AIDS declined in the
West; declined and then leveled in the South, Midwest, and US territories; and
declined and then increased in the Northeast. During the same period, AIDS
incidence declined sharply and then slowed among whites and declined more slowly
and then leveled among blacks, Hispanics, and Asians/Pacific Islanders. During
1998-2000, incidence increased among American Indians/Alaska natives from 152
in 1998 to 183 in 2000. AIDS incidence declined sharply and then slowed among
men who have sex with men (MSM) and injection-drug users. Incidence continued to
decline among MSM who also were injection-drug users. Among persons exposed
through heterosexual contact, incidence declined slowly during 1996-1998 and
then increased from 10,258 in 1999 to 11,136 in 2000.
As shown in Table 1, during 1996-1997, the estimated number
of deaths among persons with AIDS declined 42%; during 1998-2000, declines
were smaller (5% during 1998-1999 and 10% during 1999-2000). During 1996-2000,
the number of deaths declined in the Northeast, West, and Midwest; during 1996-1999,
deaths declined in the South and US territories, and then leveled during 1999-2000.
The number of deaths declined in all racial/ethnic groups and among MSM, male
and female injection-drug users, and MSM/injection-drug users. During 1996-1998,
the number of deaths among men and women with AIDS attributed to heterosexual
contact declined and then leveled during 1999-2000.
AIDS prevalence has increased steadily over time. As of
December 31, 2000, an estimated 337,731 persons in the United States were living
with AIDS (Figure 1). Of these, an estimated 139,522 (41%) were black, 127,838
(38%) white, 65,991 (20%) Hispanic, 2,841 (1%) Asian/Pacific Islanders, and
1,180 (< 1%) American Indians/Alaska Natives. An estimated 129,333 (38%)
lived in the South, 99,482 (29%) in the Northeast, 66,085 (20%) in the West,
32,909 (10%) in the Midwest, and 9,922 (3%) in US territories.
Of the estimated 264,149 adult and adolescent (ie, ³
13-year-old) males living with AIDS, approximately 151,325 (57%) were MSM,
64,522 (24%) were injection-drug users, and 20,528 were MSM/injection-drug
users; 23,333 (9%) were exposed through heterosexual contact. Of the estimated
69,775 adult and adolescent women living with AIDS, 40,051 (57%) were exposed
through heterosexual contact, and 27,475 (39%) were injection-drug users. An
estimated 3,807 children aged < 13 years were living with AIDS; of these,
approximately 90% were infected perinatally.
Editorial Note From the CDC
During 1996-2000, the incidence of AIDS declined or leveled
in most geographic regions and among most racial/ethnic groups and HIV-exposure
categories; incidence increased slightly among persons exposed heterosexually
and among persons living in the Northeast. Although the number of deaths among
persons with AIDS declined during 1996-2000, the magnitude of the decline
varied by region and exposure category. The number of deaths declined among
persons with AIDS in all racial/ethnic groups.
Declines in AIDS incidence and deaths are associated
primarily with the widespread use of HAART, which slows progression of HIV
infection to AIDS and of AIDS to death. Because effective therapy increases
AIDS-free survival rates among persons living with HIV, new AIDS diagnoses
increasingly represent persons who have failed HAART or have limited access to
or use of HIV testing or of appropriate medical care and social services.
Monitoring the entire spectrum of HIV disease, including the number of new HIV
infections, progression of HIV infection to AIDS, and deaths among persons with
AIDS, is critical for evaluating prevention efforts aimed at reducing the number
of new HIV infections and preventing morbidity and mortality among persons
living with HIV.
As of December 2000, an estimated 340,000 persons in the
United States were living with AIDS. Increasing proportions of persons living
with AIDS are black and Hispanic, female, residents of the South, and persons
exposed to HIV through heterosexual contact. This finding is consistent with
other studies that indicate HIV and AIDS disproportionately affect subgroups
that traditionally have had limited access to medical and preventive services
because of poverty and social disadvantage. This is particularly important for
interpreting trends in AIDS because access to high-quality medical services
facilitates early treatment of HIV infection and can delay the onset of AIDS.
Many persons in historically disadvantaged groups might lack access to or not
seek adequate health-care services.
An estimated one-fourth of persons living with HIV in the
United States are not aware of their infection and their need for services, and
one-third of persons who are aware of their infection are not receiving care.
Efforts to meet the preventive service and health-care needs of persons living
with HIV/AIDS are imperative to improving their quality of life and preventing
further transmission of HIV. For the United States to meet the national goal of
reducing new HIV infections by half by 2005, improved access to and use of HIV
testing and other preventive services, access to care and comprehensive
services, and improvement in HIV therapies are required.
Reported by R.M. Klevens and J.J. Neal, Division of HIV/AIDS
Prevention, National Center for HIV, STD, and TB Prevention, CDC. Adapted from
Morbidity and Mortality Weekly Report 51(27):592-595, 2000.