Brain Tumors

Intracranial neoplasms can arise from any of the structures or cell types present in the cranial vault, including the brain, meninges, pituitary gland, skull, and even residual embryonic tissue. The overall annual incidence of primary brain tumors in the United States is 14 cases per 100,000 population. More »

A mobile MRI unit recently pulled up to the steps of Capitol Hill, launching the Brain Tumor Foundation's national campaign for early detection. Led by the Foundation's president and founder, Patrick J. Kelly, MD, free brain scans were offered to members of Congress and their staff, along with government officials. Good intentions aside, the effort was derided as doing more harm than good by many leading cancer experts. More »

Intracranial neoplasms can arise from any of the structures or cell types present in the cranial vault, including the brain, meninges, pituitary gland, skull, and even residual embryonic tissue. The overall annual incidence of primary brain tumors in the United States is 14 cases per 100,000 population. More »

The review by Gururangan and Friedman takes an interesting and informative approach to pediatric brain tumors in emphasizing the possible biologic bases for chemotherapy failure in these neoplasms in general, and focusing on newer, as yet largely unproven, strategies employing “biologic” therapies to circumvent such mechanisms of tumor resistance. Many of these newer treatment strategies are drawn from the work of the authors and others in the field of adult malignant gliomas. To date, minimal... More »

PHILADELPHIA -- Epidemiologists have associated vitamins taken by women around the time of conception and in early pregnancy and the risk of brain cancer for their children. More »

brain tumor, neuroma, tumorigenesis, cell phone use More »

While the majority of primary central nervous system (CNS) tumors occur in patients over the age of 45 years, they are also the most prevalent solid neoplasms of childhood. About 16% of patients with brain tumors have a family history of cancer, and evidence points to chromosomal and genetic abnormalities. Magnetic resonance imaging (MRI) is superior to computed tomography (CT) in localizing tumors and in evaluating edema, hydrocephalus, and hemorrhage. More »

Sri Gururangan and Henry Friedman present a thoughtful review of advances in pediatric neurooncology. Coupled with the recent review of pediatric brain tumor biology written by Richard Gilbertson, these articles highlight the value that the pediatric neuro-oncology community places on translating signal transduction modifiers into clinical practice.[1] The remainder of this commentary focuses on the challenges and opportunities associated with developing more effective and less toxic therapies... More »

Central nervous system (CNS) cancers are the second most frequent malignancy (and the most common solid tumor) in childhood. In recent years, significant advances in surgery, radiotherapy, and chemotherapy have improved survival in children with these tumors. However, a significant proportion of patients with CNS tumors suffer progressive disease despite such treatment. Advances in the understanding of the nature of the blood-brain/tumor barrier, chemotherapy resistance, tumor biology, and the... More »

NIAGARA-ON-THE-LAKE, Ontario, Canada—Survivors of childhood brain tumors appear to have a high risk for non-neurological late effects such as endocrine disorders, according to a report (abstract 7) presented at the 7th International Conference for Long-Term Complications of Treatment of Children and Adolescents for Cancer, hosted by Roswell Park Cancer Institute. More »