Oncologists Need to Rely Upon NPs, PAs, and NPPs to Overcome Workforce Problems
Eric P. Winer, MD, said, “[Health care] has a workforce problem, which is part of the reason why we need to embrace nurse practitioners and PAs, or APPs.”
78 Comparison of Positive Margin Rate of Breast Cancer in Higher BMI Patients
Neoadjuvant Endocrine Therapy Could Sway Breast Cancer Radiation Paradigms
Ninety days of endocrine therapy before surgery could change patient/surgeon preference on concurrent radiation use in those with breast cancer.
FDA Sends CRL for PET Imaging Agent in Progressive/Recurrent Glioma
The FDA requires additional confirmatory evidence to progress the application for TLX101-CDx in this glioma indication.
Beyond Surgery: The Evolving Landscape of Adjuvant Therapy in Kidney Cancer
Oncology Decoded hosts discuss adjuvant therapy in kidney cancer, including research, treatment strategies, and management of recurrence.
KN026/Chemo Meets PFS End Point in HER2+ Gastric Cancer in 2L Setting
Results from the phase 2/3 trial also show a favorable OS trend for KN026 with chemotherapy vs placebo with chemotherapy in HER2-positive gastric cancer.
Nogapendekin Alfa Inbakicept Elicits Promising Efficacy in Bladder Carcinoma
Nogapendekin alfa inbakicept plus BCG led to a CR rate of 71%, with 60% of responders maintaining their response for at least 12 months, in patients with bladder carcinoma in situ.
Sotorasib at 960 mg Plus Panitumumab Emerges as SOC in KRAS G12C+ mCRC
Results from the phase 3 CodeBreaK trial support the use of 960 mg of sotorasib plus panitumumab as standard of care in metastatic colorectal cancer.
Perioperative Pembrolizumab Enhances Survival in Locally Advanced HNSCC
Event-free survival events were observed in 37.5% of patients with resectable locally advanced HNSCC who took pembrolizumab vs 45.3% in those who did not.
79 Case Series of Pathologic Upgrade After Reconstructive Breast Surgery
Linvoseltamab Receives EU Approval for Relapsed/Refractory Multiple Myeloma
The EU approval was based on results from the phase 1/2 LINKER-MM1 trial assessing the efficacy of linvoseltamab in relapsed/refractory multiple myeloma.
Societal Changes, COVID-19 Among Causes of Oncologist Burnout
“Although telehealth is a great thing when used properly, telehealth also puts a barrier between the doctor and the patient,” said Eric P. Winer, MD.
Bone Marrow Test Reveals Improved Survival in NPM1 and FLT3-Mutated AML
This study conducted within the phase 3 AML17 and AML19 trials revealed an OS rate of 69% in patients monitored for MRD and 58% in those not monitored.
FDA Approves Multi-Dose Thiotepa Vial for Breast and Ovarian Cancers
The regulatory decision may offer more scheduling flexibility for patients who receive thiotepa for breast or ovarian cancer.
Anlotinib Combo Improves PFS/OS in Extensive-Stage Small Cell Lung Cancer
Data may support anlotinib/benmelstobart plus chemotherapy as a preferable frontline treatment option in extensive-stage small cell lung cancer.
The CHMP Recommends Acalabrutinib Combos For Approval in Untreated CLL
Results from the phase 3 AMPLIFY trial showed that acalabrutinib plus venetoclax, with or without obinutuzumab, prolonged PFS vs chemoimmunotherapy in CLL.
Cretostimogene Grenadenorepvec Displays Efficacy in BCG-Unresponsive NMIBC
Complete response rates were observed consistently across patient subgroups in those with high-risk BCG-unresponsive non-muscle invasive bladder cancer.
81 Assessing Recurrence Likelihood in Hormone Receptor–Positive/HER2-Negative Breast Cancer Patients Directly From MRI Using Imaging AI
Investigators Discontinue Trial Assessing Capivasertib in Metastatic CRPC
A recommendation from an independent data monitoring committee prompted the discontinuation of the phase 3 CAPItello-280 trial.
PET/CT Lymph Node Staging Doesn't Predict Worse Outcomes After Bladder Cancer Surgery
18F-FDG PET/CT staging of lymph node metastases in patients with bladder cancer undergoing radical cystectomy did not correlate with worse survival outcomes.
Surgical Overtreatment Has Declined in Grade Group 1 Prostate Cancer
Data show that patients who undergo grade group 1 prostatectomies may experience an increased likelihood of higher risk features.
Outpatient Robotic Partial Nephrectomy Is Safe/Feasible for Renal Tumors
A prospective trial established that 97% of patients were successfully discharged on the same day as receiving robotic partial nephrectomy.
Pelvic Radiation Confers More Complications After Bladder Cancer Surgery
Findings may establish a framework for assisting patient counselling and optimizing therapy selection for those undergoing radical cystectomy.
Hypofractionated RT Shows Portal Vein Tumor Thrombosis Control, OS in HCC
Ten-fraction image-guided hypofractionated radiation therapy could be a feasible treatment option for portal vein tumor thrombosis in patients with HCC.
Organ Preservation Noted With Neoadjuvant Dostarlimab in dMMR Tumors
A phase 2 study found a complete clinical response of 82% with neoadjuvant dostarlimab in dMMR solid tumors.
Zanidatamab Recommended for Conditional Marketing Approval in Advanced HER2+ BTC
The recommendation from the CHMP is based on results from the phase 2b HERIZON-BTC-01 trial of zanidatamab in advanced HER2+ biliary tract cancer.
Low-Dose CT Screening for Lung Cancer Shows Large-Scale Efficacy
Study data show a small number of individuals with a lung cancer diagnosis within 12 months of a negative baseline screening result.
Nurulimab/Prolgolimab Yield Superior Efficacy in Advanced Melanoma
The combination of nurulimab plus prolgolimab enhanced PFS, ORR, and DCR compared with prolgolimab monotherapy in unresectable or metastatic melanoma.
82 Efficacy, Safety, and Biomarker Analysis of ICARUS-BREAST01: A Phase 2 Study of Patritumab Deruxtecan (HER3-DXd) in Patients With HR+/HER2– Advanced Breast Cancer
Same-Day G-CSF After Chemo Appears Safe, Efficacious in Breast Cancer
No grade 3/4 treatment-related adverse effects were observed in patients receiving efbemalenograstim alfa for breast cancer in the Guard-02 trial.