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Prostate Cancer

The Bifunctional Role of Steroid Hormones

This review examines the relevance of a translational framework for studying therapeutic androgens in prostate cancer.

Commentaries:
New Concepts Regarding Testosterone and Prostate Cancer: A Breath of Fresh Air
Friend or Foe: The Bifunctional Role of Steroid Hormones in Prostate Cancer

Prostate Cancer

Urologists More Likely to Treat Low-Risk Prostate Cancer

Anna Azvolinsky, PhD
News | July 24, 2014 | Prostate Cancer, Genitourinary Cancers
By

How low-risk prostate cancer is managed depends more on the diagnosing physician than the patient’s disease state. Men who were diagnosed by a urologist were more likely to receive a treatment performed by the urologist and more likely to receive a therapy rather than monitoring.

Extended Lymph Node Dissection in Prostate Cancer: A Procedure With Therapeutic Utility

Giorgio Gandaglia, MD
Ettore Di Trapani, MD
Alberto Briganti, MD
July 15, 2014 | Oncology Journal, Prostate Cancer
By , , and

Extended pelvic lymph node dissection represents the most accurate procedure for the detection of lymph node metastases in prostate cancer.

Extended Pelvic Lymph Node Dissection for Prostate Cancer: Do More Nodes Mean Better Survival?

Daniel A. Wollin, MD
Danil Makarov, MD, MHS
July 15, 2014 | Oncology Journal, Prostate Cancer
By and

At the present time, without clear data to suggest improved survival for patients undergoing extended pelvic lymph node dissection, the procedure cannot be universally recommended.

Vasectomies Linked to Higher Incidence of Prostate Cancer

Anna Azvolinsky, PhD
News | July 10, 2014 | Genitourinary Cancers, Prostate Cancer
By

Men who underwent a vasectomy had a modest increase in the incidence of prostate cancer—and particularly lethal prostate cancer.

CHAARTED: ADT Plus Docetaxel in Prostate Cancer

Michael J. Morris, MD
Conference Report | June 30, 2014 | ASCO 2014, ASCO 2014 Prostate Cancer, Genitourinary Cancers, Prostate Cancer
By

Dr. Morris discusses results and implications of the CHAARTED trial, which studied the survival impact of androgen deprivation therapy (ADT) plus docetaxel vs ADT alone for hormone-sensitive newly metastatic prostate cancer.

The Role of Radical Prostatectomy and Lymph Node Dissection in the Treatment of Young Men With High-Grade Node-Positive Prostate Cancer: There May Be No RCTs—but There Are Good Reasons to Include Surgery

Simon P. Kim, MD, MPH
Marc C. Smaldone, MD, MSHP
June 15, 2014 | Oncology Journal, Genitourinary Cancers, Prostate Cancer
By and

Upfront surgery allows for greater freedom to use all secondary treatment options for local and distant control, including adjuvant radiotherapy and ADT, thereby hopefully obviating the significant adverse quality-of-life sequelae from salvage surgery and brachytherapy for local relapse.

The Role of Radical Prostatectomy and Lymph Node Dissection in the Treatment of Young Men With High-Grade Node-Positive Prostate Cancer: Less Is More—the Benefits of Surgery Do Not Yet Outweigh Potential Harms

Paul L. Nguyen, MD
June 15, 2014 | Oncology Journal, Genitourinary Cancers, Prostate Cancer
By

Under current conditions for patients with newly diagnosed node-positive prostate cancer, the benefits of surgery, if any, are highly unlikely to outweigh the known harms--less is still more.

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