Shulin Li, PhD, Lends Insight on Role of FGL2 Protein in Glioblastoma Immune Evasion
Cancer Network spoke with Dr. Shulin Li about his team’s research on the role of the FGL2 protein in glioblastoma immune evasion and tumor progression.
NCCN: Updated Guidelines Reflect Advances, ‘Immunotherapy Era’ for Breast Cancer
Among the updates are expanded treatment options, including a recently approved immunotherapy regimen for locally advanced or metastatic disease.
NCCN: More Genetic Testing to Inform Prostate Cancer Management
Updated prostate cancer guidelines reflect the importance of tumor genetic testing and genomically-informed disease management.
NCCN: Costly Innovative Cancer Therapies Pose New Challenges-Financial and Otherwise
Experts shared the challenges they've encountered in integrating novel treatments such as CAR T-cell therapy into practice at the 2019 NCCN Annual Conference.
NCCN: Updated NSCLC Guidelines Hone in on PD-L1 Testing
The revised version focuses on the first-line use of immunotherapy and the measurement of tumor cells expressing PD-L1.
Does Age at Diagnosis Impact Clinical and Molecular Features of Colorectal Cancer?
Research published in Cancer evaluated whether colorectal cancers diagnosed in early adulthood differ from those diagnosed at older ages.
Cell-Cell Communication in the Tumor Microenvironment
Cancer Network speaks with Peter Ruvolo, PhD, about his work investigating the role of microenvironments in cancer and treatment resistance.
Novel Genetic Marker in Ovarian, Lung Cancers
Two new studies found that targeting the cyclin-dependent kinases 4/6 exposed a vulnerability in SMARCA4-deficient cancers.
New Biomarker Recognized For Colorectal Cancers
A recent study identified a new biomarker in colorectal cancers that may assist in early detection of the disease.
HPV Gene Expression Signatures, Prognosis in Cervical Cancers
Cancer Network spoke with Curtis Pickering, PhD, about prognostic gene expression signatures for HPV-positive oropharyngeal and cervical cancers.
Understanding The Regulatory Roles of lncRNA
Cancer Network speaks with Dr. Pavel Sumazin about his ongoing efforts to further understand how lncRNA influence genes with known function in cancers.
Alternative RNA Splicing and Tumor Progression
Cancer Network speaks with Eduardo Eyras, PhD about the emerging roles of RNA splicing variants in cancer treatment.
Monitoring WT1 mRNA to Detect AML Relapse
A study shows sequential monitoring of the WT1 mRNA is of value for the early detection of hematologic relapse in patients with AML in remission.
Can Azacitidine Delay Relapse in MRD-Positive AML?
Azacitidine may delay or prevent relapse among patients with MRD-positive acute myeloid leukemia or myelodysplastic syndrome.
Do Targeted Agents Aid Melanoma Immunotherapy?
Guy Ben-Betzalel, MD spoke with Cancer Network about the emerging role of targeted BRAF+MEK inhibition in antitumor immunity.
Emerging Targets in Cancer Immunotherapy
Professor Lana E. Kandalaft, PharmD, PhD spoke with Cancer Network about the next generation of cancer immunotherapy.
Predicting Tumor Patterns Using Ubiquitin Pathway Genes
Professor Han Liang speaks with Cancer Network about the ubiquitin pathway and its role in cancer research.
Link Found Between mTORC1, G2/M DNA Damage Checkpoint
Guang Peng, MD, PhD spoke to Cancer Network about the recent discovery that mTORC1 can help determine cell fate after DNA damage.
Why Cancer Gene Variants are Frequently Reclassified
A study shows gene variants of uncertain significance are frequently reclassified, necessitating amended test result reports.
FDA Approves Next-Generation Sequencing Test For MRD Detection
The FDA authorized the first next-generation sequencing test to detect minimal residual disease in blood cancers.
Applying Nanotechnologies for Immunotherapy
Nanotechnological strategies are making preclinical strides toward more effective, less toxic, immunotherapies.
TRK Fusions Identified in Hematologic Cancers
A study shows TRK gene fusions in hematologic cancers may respond to larotrectinib.
Sarcoma-Associated Gene Fusions a Result of ‘Genome Chaos’
A study finds EWSR1-ETS in 42% of cases via complex, loop-like rearrangements, rather than by simple reciprocal translocations.
Gene Variant Linked to Risk of Oral Squamous Cell Carcinoma
A study shows significant association between MTHFR C677T polymorphisms and risk of oral squamous cell carcinoma.
Does Radioactive Iodine Post Reoperation Improve Thyroid Cancer Outcomes?
A study shows that receipt of radioactive iodine after reoperation may not be associated with improved outcomes.
Using Targeted Deep Sequencing to Detect ctDNA in Pancreatic Cancer
Study shows that ctDNA levels measured by targeted deep sequencing sensitively indicate the presence of cancer.
Targeting Inflammation Slows STK11 Mutation-Driven Polyp Growth
A study shows that LKB1 deficiency in T cells increases gastrointestinal polyposis development.
Researchers Call for More Conservative Treatment of Small Thyroid Cancers
The steep increase in thyroid cancer diagnosis has not been mirrored by increasing mortality rates and is likely due to widespread overdiagnosis of small neoplasms.
Could Leukocyte DNA Methylation Patterns Inform Treatment of Thyroid Cancer?
Brazilian researchers say their study results “suggest the overall DNA methylation profile may be influenced by the histological subtype of thyroid cancer.”
Enhance Immunotherapy by Reversing T-Cell Exhaustion?
Tumor microenvironments can induce T-cell senescence and exhaustion; Yangqiu Li et al highlight ways to reverse these states and improve immunotherapeutic efficacy.